Derl3 Gene Detail

Summary

• Symbol
  Derl3
• Name
  Der1-like domain family, member 3
• Synonyms
  1810006I20Rik, 1810063P04Rik, derlin-3, IZP6

• Feature Type
  protein coding gene
• IDs
  MGI:1917627
  NCBI Gene: 70377
• Alliance
  gene page
• Transcription Start Sites
  2 TSS

Location &
Maps

• Sequence Map
  Chr10:75729247-75731775 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 10, 38.61 cM, cytoband B5.3
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  123 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917627	protein coding gene	Chr10:75729232-75731775 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017369	protein coding gene	Chr10:76095711-76098254 (+)
A/J	MGP_AJ_G0017346	protein coding gene	Chr10:73477380-73479923 (+)
AKR/J	MGP_AKRJ_G0017307	protein coding gene	Chr10:75450507-75453050 (+)
BALB/cJ	MGP_BALBcJ_G0017306	protein coding gene	Chr10:73673588-73676131 (+)
C3H/HeJ	MGP_C3HHeJ_G0017130	protein coding gene	Chr10:75498024-75500567 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017764	protein coding gene	Chr10:78787537-78790080 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015454	protein coding gene	Chr10:69928148-69930678 (+)
CAST/EiJ	MGP_CASTEiJ_G0016701	protein coding gene	Chr10:75813857-75816400 (+)
CBA/J	MGP_CBAJ_G0017102	protein coding gene	Chr10:81860038-81862581 (+)
DBA/2J	MGP_DBA2J_G0017207	protein coding gene	Chr10:72775877-72778420 (+)
FVB/NJ	MGP_FVBNJ_G0017200	protein coding gene	Chr10:71931126-71933669 (+)
LP/J	MGP_LPJ_G0017280	protein coding gene	Chr10:76594179-76596722 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017228	protein coding gene	Chr10:83952004-83954547 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017803	protein coding gene	Chr10:75486299-75488842 (+)
PWK/PhJ	MGP_PWKPhJ_G0016484	protein coding gene	Chr10:72601377-72603904 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016267	protein coding gene	Chr10:74737384-74739923 (+)
WSB/EiJ	MGP_WSBEiJ_G0016764	protein coding gene	Chr10:75468708-75471242 (+)

Homology

• Human Ortholog
  DERL3, derlin 3

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  DERL3, derlin 3
  
• Synonyms
  C22orf14, derlin-3, IZP6, LLN2
• Links
  HGNC:14236

  NCBI Gene ID: 91319

  neXtProt AC: NX_Q96Q80

  UniProt: Q96Q80

  
  
• Chr Location
  22q11.23

---

• MGI Vertebrate Homology
  Derl3 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: DERL3
• Gene Tree
  Derl3
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2 phenotypes from 2 alleles in 2 genetic backgrounds
  9 phenotype references
  

• All Mutations and Alleles
  4
• Chemically induced (other)
  1
• Endonuclease-mediated
  1
• Gene trapped
  1
• Targeted
  1
• Genomic Mutations
  1 involving Derl3
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  11 strains or lines available

Mice homozygous for this gene trapped allele show no obvious phenotype alterations.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  17
• GO References
  5

Expression

• Assay Results
  764
• Tissues
  45
• cDNA Data
  47
• Literature Summary
  4

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  54
• RefSeq
  10
• UniProt
  3
• CCDS
  CCDS23935.1, CCDS88024.1

• Ensembl
  ENSMUSG00000009092 (Evidence)
• NCBI Gene
  70377

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000009092	Ensembl Gene Model | MGI Sequence Detail	2529	C57BL/6J
transcript	ENSMUST00000009236	Ensembl | MGI Sequence Detail	1321	Not Applicable
polypeptide	ENSMUSP00000009236	Ensembl | MGI Sequence Detail	228	Not Applicable

Protein
Information

• UniProt
  3 Sequences
• Protein Ontology
  PR:000006424 derlin-3
  (term hierarchy)
• InterPro Domains
  IPR007599 Derlin
  IPR035952 Rhomboid-like superfamily

Molecular
Reagents

• All nucleic 49

  cDNA 47

  Primer pair 2

  
  

  Microarray probesets 3

Other
Accession IDs

MGI:1916287

References

• Summaries
  All 40

  Developmental Gene Expression 4

  Gene Ontology 5

  Phenotypes 9
• Earliest
  J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
• Latest
  J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Derl3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94145	Chr10:75729237-75729263 (+)	3 bp
Tssr94146	Chr10:75729277-75729286 (+)	35 bp