C1qtnf2 MGI Mouse Gene Detail - MGI:1916433 - C1q and tumor necrosis factor related protein 2

Symbol

C1qtnf2
Name

C1q and tumor necrosis factor related protein 2
Synonyms

1810033K05Rik, CTRP2

Feature Type

protein coding gene
IDs

MGI:1916433
NCBI Gene: 69183
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr11:43365103-43382352 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 25.72 cM, cytoband B1.1
Mapping Data

2 experiments

SNPs within 2kb

872 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916433	protein coding gene	Chr11:43364984-43382485 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018173	protein coding gene	Chr11:42237031-42252407 (+)
A/J	MGP_AJ_G0018145	protein coding gene	Chr11:40627162-40644305 (+)
AKR/J	MGP_AKRJ_G0018109	protein coding gene	Chr11:41818509-41838776 (+)
BALB/cJ	MGP_BALBcJ_G0018114	protein coding gene	Chr11:40808441-40823758 (+)
C3H/HeJ	MGP_C3HHeJ_G0017927	protein coding gene	Chr11:41854320-41870604 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018568	protein coding gene	Chr11:43531014-43554116 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016223	protein coding gene	Chr11:38692061-38710023 (+)
CAST/EiJ	MGP_CASTEiJ_G0017491	protein coding gene	Chr11:41899441-41916547 (+)
CBA/J	MGP_CBAJ_G0017900	protein coding gene	Chr11:45538146-45553474 (+)
DBA/2J	MGP_DBA2J_G0018010	protein coding gene	Chr11:40412663-40430460 (+)
FVB/NJ	MGP_FVBNJ_G0018004	protein coding gene	Chr11:40095236-40114260 (+)
LP/J	MGP_LPJ_G0018082	protein coding gene	Chr11:42481561-42497766 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018028	protein coding gene	Chr11:47184055-47201485 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018607	protein coding gene	Chr11:41974979-41994060 (+)
PWK/PhJ	MGP_PWKPhJ_G0017272	protein coding gene	Chr11:40431802-40449588 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017064	protein coding gene	Chr11:41766387-41787319 (+)
WSB/EiJ	MGP_WSBEiJ_G0017540	protein coding gene	Chr11:41615244-41633660 (+)

Human Ortholog

C1QTNF2, C1q and TNF related 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

C1QTNF2, C1q and TNF related 2
Synonyms

CTRP2, zacrp2
Links

HGNC:14325

NCBI Gene ID: 114898

neXtProt AC: NX_Q9BXJ5

UniProt: Q9BXJ5
Chr Location

5q33.3; chr5:160347754-160370641 (-) GRCh38

MGI Vertebrate Homology

C1qtnf2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: C1QTNF2
Gene Tree

C1qtnf2

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Phenotype Summary

28 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving C1qtnf2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show decreased body weight, reduced adiposity, increased metabolic rate and energy expenditure, enhanced adipose tissue lipolysis, and altered hepatic and plasma lipid profiles.

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All GO Annotations

13
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

887
Tissues

54
cDNA Data

10
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

39
RefSeq

6
UniProt

3
CCDS

CCDS24558.1

Ensembl

ENSMUSG00000046491 (Evidence)
NCBI Gene

69183

			Length	Strain/Species	Flank
genomic	ENSMUSG00000046491	Ensembl Gene Model \| MGI Sequence Detail	17250	C57BL/6J	± kb
transcript	ENSMUST00000173002	Ensembl \| MGI Sequence Detail	1147	Not Applicable
polypeptide	ENSMUSP00000134705	Ensembl \| MGI Sequence Detail	324	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000004884 complement C1q tumor necrosis factor-related protein 2

(term hierarchy)
InterPro Domains

IPR001073 C1q domain

IPR050392 Collagen/C1q domain-containing

IPR008160 Collagen triple helix repeat

IPR008983 Tumour necrosis factor-like domain superfamily
GlyGen

Q9D8U4 1 site, 1 N-linked glycan (1 site)

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All nucleic 11

cDNA 10

Primer pair 1

Microarray probesets 3

Summaries

All 41

Developmental Gene Expression 4

Gene Ontology 4

Phenotypes 15
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for C1qtnf2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr100996	Chr11:43365084-43365094 (+)	-14 bp
Tssr100997	Chr11:43365108-43365167 (+)	35 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24