Ing5 MGI Mouse Gene Detail - MGI:1922816 - inhibitor of growth family, member 5

Symbol

Ing5
Name

inhibitor of growth family, member 5
Synonyms

1700027H23Rik, 1810018M11Rik

Feature Type

protein coding gene
IDs

MGI:1922816
NCBI Gene: 66262
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr1:93731687-93749823 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 47.34 cM, cytoband D
Mapping Data

3 experiments

SNPs within 2kb

385 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922816	protein coding gene	Chr1:93731648-93749823 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016350	protein coding gene	Chr1:95451913-95470030 (+)
A/J	MGP_AJ_G0016331	protein coding gene	Chr1:92035410-92053685 (+)
AKR/J	MGP_AKRJ_G0016292	protein coding gene	Chr1:94748810-94766888 (+)
BALB/cJ	MGP_BALBcJ_G0016287	protein coding gene	Chr1:92216341-92234738 (+)
C3H/HeJ	MGP_C3HHeJ_G0016116	protein coding gene	Chr1:95004961-95023181 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016746	protein coding gene	Chr1:99076810-99097188 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014464	protein coding gene	Chr1:86276313-86294714 (+)
CAST/EiJ	MGP_CASTEiJ_G0015699	protein coding gene	Chr1:94336241-94354433 (+)
CBA/J	MGP_CBAJ_G0016090	protein coding gene	Chr1:102296908-102315043 (+)
DBA/2J	MGP_DBA2J_G0016195	protein coding gene	Chr1:91235819-91254570 (+)
FVB/NJ	MGP_FVBNJ_G0016194	protein coding gene	Chr1:90299098-90319537 (+)
LP/J	MGP_LPJ_G0016266	protein coding gene	Chr1:96630155-96651878 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016219	protein coding gene	Chr1:105372943-105393685 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016785	protein coding gene	Chr1:94780036-94799578 (+)
PWK/PhJ	MGP_PWKPhJ_G0015484	protein coding gene	Chr1:90665610-90684238 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015268	protein coding gene	Chr1:93717886-93736423 (+)
WSB/EiJ	MGP_WSBEiJ_G0015759	protein coding gene	Chr1:94595481-94614649 (+)

Human Ortholog

ING5, inhibitor of growth family member 5

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ING5, inhibitor of growth family member 5
Synonyms

p28ING5
Links

HGNC:19421

NCBI Gene ID: 84289

neXtProt AC: NX_Q8WYH8

UniProt: Q8WYH8
Chr Location

2q37.3; chr2:241687020-241729478 (+) GRCh38

MGI Vertebrate Homology

Ing5 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ING5
Gene Tree

Ing5

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Phenotype Summary

14 phenotypes from 2 alleles in 2 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

10
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Ing5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele display partial preweaning lethality with impaired hematopoiesis in the fetal liver.

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All GO Annotations

48
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

855
Tissues

149
cDNA Data

63
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ING5

Xenbase ing5

ZFIN ing5a

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All Sequences

47
RefSeq

4
UniProt

2
CCDS

CCDS35673.1

Ensembl

ENSMUSG00000026283 (Evidence)
NCBI Gene

66262

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026283	Ensembl Gene Model \| MGI Sequence Detail	18137	C57BL/6J	± kb
transcript	ENSMUST00000027505	Ensembl \| MGI Sequence Detail	4533	Not Applicable
polypeptide	ENSMUSP00000027505	Ensembl \| MGI Sequence Detail	240	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009037 inhibitor of growth protein 5

(term hierarchy)
InterPro Domains

IPR028651 ING family

IPR024610 Inhibitor of growth protein, N-terminal histone-binding

IPR011011 Zinc finger, FYVE/PHD-type

IPR019787 Zinc finger, PHD-finger

IPR001965 Zinc finger, PHD-type

IPR019786 Zinc finger, PHD-type, conserved site

IPR013083 Zinc finger, RING/FYVE/PHD-type

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All nucleic 64

cDNA 63

Primer pair 1

Microarray probesets 6

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MGI:1913512, MGI:2138176

Summaries

All 54

Developmental Gene Expression 6

Gene Ontology 10

Phenotypes 16
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:346139 Mah SYY, et al., ING4 and ING5 are essential for histone H3 lysine 14 acetylation and epicardial cell lineage development. Development. 2024 Mar 1;151(5):dev202617

TSS for Ing5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8200	Chr1:93729873-93729889 (+)	-1,806 bp
Tssr8201	Chr1:93731667-93731720 (+)	7 bp
Tssr8202	Chr1:93739531-93739568 (+)	7,863 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24