About   Help   FAQ
Spcs1 Gene Detail
Summary
  • Symbol
    Spcs1
  • Name
    signal peptidase complex subunit 1 homolog (S. cerevisiae)
  • Synonyms
    1810004F21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916269
    NCBI Gene: 69019
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:30721783-30723330 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 19.09 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    102 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916269
 protein coding gene Chr14:30721783-30723629 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021114
 protein coding gene Chr14:24161719-24163565 (-)
A/J MGP_AJ_G0021062
 protein coding gene Chr14:23253610-23255798 (-)
AKR/J MGP_AKRJ_G0021039
 protein coding gene Chr14:24377565-24379411 (-)
BALB/cJ MGP_BALBcJ_G0021066
 protein coding gene Chr14:23359892-23361857 (-)
C3H/HeJ MGP_C3HHeJ_G0020849
 protein coding gene Chr14:24230448-24232294 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021498
 protein coding gene Chr14:25125576-25127422 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019061
 protein coding gene Chr14:23313486-23315332 (-)
CAST/EiJ MGP_CASTEiJ_G0020374
 protein coding gene Chr14:24001763-24004647 (-)
CBA/J MGP_CBAJ_G0020816
 protein coding gene Chr14:26093676-26095624 (-)
DBA/2J MGP_DBA2J_G0020938
 protein coding gene Chr14:23279529-23281375 (-)
FVB/NJ MGP_FVBNJ_G0020922
 protein coding gene Chr14:23235342-23237188 (-)
LP/J MGP_LPJ_G0021007
 protein coding gene Chr14:24487630-24489821 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020948
 protein coding gene Chr14:25351586-25353432 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021531
 protein coding gene Chr14:24132358-24134204 (-)
PWK/PhJ MGP_PWKPhJ_G0020122
 protein coding gene Chr14:22730217-22731977 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019946
 protein coding gene Chr14:23723597-23725440 (-)
WSB/EiJ MGP_WSBEiJ_G0020429
 protein coding gene Chr14:24192342-24194188 (-)



Homology
more
  • Human Ortholog
    SPCS1, signal peptidase complex subunit 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPCS1, signal peptidase complex subunit 1
  • Synonyms
    HSPC033, SPC1, SPC12, YJR010C-A
  • Links
    NCBI Gene ID: 28972
    neXtProt AC: NX_Q9Y6A9
    UniProt: Q9Y6A9

  • Chr Location
    3p21.1; chr3:52704955-52711148 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    827
  • Tissues
    96
  • cDNA Data
    167
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 69019 NCBI Gene Model | MGI Sequence Detail 1548 C57BL/6J ±  kb
transcript NM_026911 RefSeq | MGI Sequence Detail 713 C57BL/6  
polypeptide Q9D958 UniProt | EBI | MGI Sequence Detail 161 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • InterPro Domains
    IPR009542 Signal peptidase complex subunit 1
Molecular
Reagents
less
  • All nucleic 168
    cDNA 168

    Microarray probesets 5
References
more
  • Summaries
    All 33
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:113821 Kalies KU, et al., Membrane topology of the 12- and the 25-kDa subunits of the mammalian signal peptidase complex. J Biol Chem. 1996 Feb 16;271(7):3925-9
  • Latest
    J:330827 Yoo D, et al., Little skate genome provides insights into genetic programs essential for limb-based locomotion. Elife. 2022 Oct 26;11:e78345
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory