Tmco5 Gene Detail

Summary

• Symbol
  Tmco5
• Name
  transmembrane and coiled-coil domains 5
• Synonyms
  1700095F04Rik

• Feature Type
  protein coding gene
• IDs
  MGI:1914606
  NCBI Gene: 67356
• Alliance
  gene page
• Transcription Start Sites
  3 TSS

Location &
Maps

• Sequence Map
  Chr2:116709172-116722975 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 2, 59.03 cM, cytoband E5
• Mapping Data
  3 experiments

Strain
Comparison

• SNPs within 2kb
  554 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914606	protein coding gene	Chr2:116709172-116722987 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026307	protein coding gene	Chr2:119480304-119494045 (+)
A/J	MGP_AJ_G0026268	protein coding gene	Chr2:114633166-114646967 (+)
AKR/J	MGP_AKRJ_G0026247	protein coding gene	Chr2:117830922-117844693 (+)
BALB/cJ	MGP_BALBcJ_G0026281	protein coding gene	Chr2:114881563-114895270 (+)
C3H/HeJ	MGP_C3HHeJ_G0026026	protein coding gene	Chr2:118265932-118281896 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026728	protein coding gene	Chr2:123418261-123432016 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024108	protein coding gene	Chr2:109712076-109725891 (+)
CAST/EiJ	MGP_CASTEiJ_G0025489	protein coding gene	Chr2:118579493-118593270 (+)
CBA/J	MGP_CBAJ_G0026003	protein coding gene	Chr2:127772376-127786121 (+)
DBA/2J	MGP_DBA2J_G0026142	protein coding gene	Chr2:114063791-114079448 (+)
FVB/NJ	MGP_FVBNJ_G0026104	protein coding gene	Chr2:112895224-112908969 (+)
LP/J	MGP_LPJ_G0026243	protein coding gene	Chr2:119813137-119826898 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026123	protein coding gene	Chr2:132194242-132208001 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026783	protein coding gene	Chr2:117938113-117951866 (+)
PWK/PhJ	MGP_PWKPhJ_G0025225	protein coding gene	Chr2:113609134-113623176 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025024	protein coding gene	Chr2:117073448-117087766 (+)
WSB/EiJ	MGP_WSBEiJ_G0025558	protein coding gene	Chr2:118768242-118781995 (+)

Homology

• Human Ortholog
  TMCO5A, transmembrane and coiled-coil domains 5A

• Vertebrate Orthologs
  2

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  TMCO5A, transmembrane and coiled-coil domains 5A
  
• Synonyms
  TMCO5
• Links
  HGNC:28558

  NCBI Gene ID: 145942

  neXtProt AC: NX_Q8N6Q1

  UniProt: Q8N6Q1

  
  
• Chr Location
  15q14; chr15:37921939-38040865 (+)  GRCh38

---

• MGI Vertebrate Homology
  Tmco5 stringent orthology
  1 human;1 mouse;1 rat
  
• HCOP
  vertebrate homology predictions: TMCO5A
• Gene Tree
  Tmco5
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2 phenotypes from 2 alleles in 2 genetic backgrounds
  10 phenotype references
  

• All Mutations and Alleles
  6
• Chemically induced (other)
  1
• Endonuclease-mediated
  1
• Radiation induced
  1
• Targeted
  3
• Genomic Mutations
  2 involving Tmco5
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  21 strains or lines available

Male mice homozygous for a mutation are viable and show normal fertility.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  1
• GO References
  1

Expression

• Assay Results
  708
• Tissues
  2
• cDNA Data
  7
• Literature Summary
  1

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  52
• RefSeq
  15
• UniProt
  3
• CCDS
  CCDS16569.1

• Ensembl
  ENSMUSG00000027355 (Evidence)
• NCBI Gene
  67356

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000027355	Ensembl Gene Model | MGI Sequence Detail	13804	C57BL/6J
transcript	ENSMUST00000028834	Ensembl | MGI Sequence Detail	1164	Not Applicable
polypeptide	ENSMUSP00000028834	Ensembl | MGI Sequence Detail	303	Not Applicable

Protein
Information

• UniProt
  3 Sequences
• Protein Ontology
  PR:000031670 transmembrane and coiled-coil domain-containing protein 5A
  (term hierarchy)
• InterPro Domains
  IPR026617 Transmembrane and coiled-coil domain-containing protein 2/5

Molecular
Reagents

• All nucleic 8

  cDNA 8

  
  

  Microarray probesets 3

References

• Summaries
  All 34

  Developmental Gene Expression 1

  Gene Ontology 1

  Phenotypes 10
• Earliest
  J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
• Latest
  J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tmco5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr19470	Chr2:116709153-116709163 (+)	-14 bp
Tssr19471	Chr2:116709167-116709177 (+)	0 bp
Tssr19472	Chr2:116709179-116709224 (+)	30 bp