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Gtf2h1 Gene Detail
Summary
  • Symbol
    Gtf2h1
  • Name
    general transcription factor II H, polypeptide 1
  • Synonyms
    62kDa, p62
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277216
    NCBI Gene: 14884
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:46445527-46473224 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 30.58 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    724 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277216
 protein coding gene Chr7:46445518-46473224 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032273
 protein coding gene Chr7:47193903-47224331 (+)
A/J MGP_AJ_G0032252
 protein coding gene Chr7:46220498-46248420 (+)
AKR/J MGP_AKRJ_G0032188
 protein coding gene Chr7:47522163-47554810 (+)
BALB/cJ MGP_BALBcJ_G0032264
 protein coding gene Chr7:46223442-46250680 (+)
C3H/HeJ MGP_C3HHeJ_G0031977
 protein coding gene Chr7:48003415-48032290 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032754
 protein coding gene Chr7:49463534-49492967 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029770
 protein coding gene Chr7:48758882-48786371 (+)
CAST/EiJ MGP_CASTEiJ_G0031305
 protein coding gene Chr7:39469690-39498508 (+)
CBA/J MGP_CBAJ_G0031942
 protein coding gene Chr7:51124774-51157916 (+)
DBA/2J MGP_DBA2J_G0032099
 protein coding gene Chr7:45896202-45925451 (+)
FVB/NJ MGP_FVBNJ_G0032053
 protein coding gene Chr7:45701716-45729740 (+)
LP/J MGP_LPJ_G0032180
 protein coding gene Chr7:47893692-47922860 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032090
 protein coding gene Chr7:49739035-49767809 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032771
 protein coding gene Chr7:46730599-46759035 (+)
PWK/PhJ MGP_PWKPhJ_G0031028
 protein coding gene Chr7:39276667-39306198 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030868
 protein coding gene Chr7:34749685-34784809 (+)
WSB/EiJ MGP_WSBEiJ_G0031425
 protein coding gene Chr7:47235181-47268435 (+)



Homology
more
  • Human Ortholog
    GTF2H1, general transcription factor IIH subunit 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GTF2H1, general transcription factor IIH subunit 1
  • Synonyms
    BTF2, P62, TFB1, TFIIH
  • Links
    NCBI Gene ID: 2965
    neXtProt AC: NX_P32780
    UniProt: P32780

  • Chr Location
    11p15.1; chr11:18322295-18367045 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    750
  • Tissues
    44
  • cDNA Data
    116
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000006599 Ensembl Gene Model | MGI Sequence Detail 27698 C57BL/6J ±  kb
transcript ENSMUST00000107644 Ensembl | MGI Sequence Detail 2187 Not Applicable  
polypeptide ENSMUSP00000103271 Ensembl | MGI Sequence Detail 553 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 121
    Genomic 5
    cDNA 116

    Microarray probesets 3
Other
Accession IDs
less
MGI:2142275, MGI:2142277, MGI:2142323
References
more
  • Summaries
    All 48
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 8
  • Earliest
    J:48344 Perez C, et al., Genomic organization and promoter characterization of the mouse and human genes encoding p62 subunit of the transcription/DNA repair factor TFIIH. Gene. 1998 Jun 15;213(1-2):73-82
  • Latest
    J:345184 Simon Y, et al., The insulin-like growth factor 2 (IGF2) mRNA-binding protein p62/IGF2BP2-2 as a promoter of NAFLD and HCC?. Gut. 2014 May;63(5):861-3
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory