Rsrc1 MGI Mouse Gene Detail - MGI:1914130 - arginine/serine-rich coiled-coil 1

Symbol

Rsrc1
Name

arginine/serine-rich coiled-coil 1
Synonyms

1200013F24Rik, SRrp53

Feature Type

protein coding gene
IDs

MGI:1914130
NCBI Gene: 66880
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr3:66888723-67265729 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 30.77 cM, cytoband E2
Mapping Data

2 experiments

SNPs within 2kb

6886 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914130	protein coding gene	Chr3:66888694-67265736 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027278	protein coding gene	Chr3:66122547-66511387 (+)
A/J	MGP_AJ_G0027239	protein coding gene	Chr3:64188673-64560591 (+)
AKR/J	MGP_AKRJ_G0027208	protein coding gene	Chr3:65537691-65928851 (+)
BALB/cJ	MGP_BALBcJ_G0027251	protein coding gene	Chr3:64037799-64421466 (+)
C3H/HeJ	MGP_C3HHeJ_G0026995	protein coding gene	Chr3:65808235-66186379 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027697	protein coding gene	Chr3:68590580-69009378 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025050	protein coding gene	Chr3:60543091-60897992 (+)
CAST/EiJ	MGP_CASTEiJ_G0026442	protein coding gene	Chr3:65750459-66128891 (+)
CBA/J	MGP_CBAJ_G0026970	protein coding gene	Chr3:70719328-71143665 (+)
DBA/2J	MGP_DBA2J_G0027106	protein coding gene	Chr3:63694786-64059124 (+)
FVB/NJ	MGP_FVBNJ_G0027074	protein coding gene	Chr3:62334437-62697097 (+)
LP/J	MGP_LPJ_G0027214	protein coding gene	Chr3:67062297-67446735 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027092	protein coding gene	Chr3:75317096-75812982 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027755	protein coding gene	Chr3:65447963-65819989 (+)
PWK/PhJ	MGP_PWKPhJ_G0026176	protein coding gene	Chr3:63441069-63808869 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025992	protein coding gene	Chr3:64587769-64942872 (+)
WSB/EiJ	MGP_WSBEiJ_G0026520	protein coding gene	Chr3:65553240-65929651 (+)

Human Ortholog

RSRC1, arginine and serine rich coiled-coil 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RSRC1, arginine and serine rich coiled-coil 1
Synonyms

BM-011, MRT70, SFRS21, SRrp53
Links

HGNC:24152

NCBI Gene ID: 51319

neXtProt AC: NX_Q96IZ7

UniProt: Q96IZ7
Chr Location

3q25.32; chr3:158105855-158545730 (+) GRCh38

MGI Vertebrate Homology

Rsrc1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RSRC1
Gene Tree

Rsrc1

Diseases

1 with human RSRC1 associations

				Human Disease	Mouse Models
				autosomal recessive intellectual developmental disorder 70 IDs autosomal recessive intellectual developmental disorder 70 DOID:0081231 OMIM:618402

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

10 phenotype references

All Mutations and Alleles

27
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

23
Radiation induced

1
Genomic Mutations

2 involving Rsrc1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

57 strains or lines available

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All GO Annotations

18
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

97
Literature Summary

4

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rsrc1

ZFIN rsrc1

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All Sequences

114
RefSeq

34
UniProt

10
CCDS

CCDS17394.1, CCDS89634.1, CCDS89635.1

Ensembl

ENSMUSG00000034544 (Evidence)
NCBI Gene

66880

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034544	Ensembl Gene Model \| MGI Sequence Detail	377007	C57BL/6J	± kb
transcript	ENSMUST00000065074	Ensembl \| MGI Sequence Detail	3224	Not Applicable
polypeptide	ENSMUSP00000066797	Ensembl \| MGI Sequence Detail	334	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000014334 arginine/serine-rich coiled-coil protein 1

(term hierarchy)
InterPro Domains

IPR034604 Serine/Arginine-related protein 53

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All nucleic 97

cDNA 97

Microarray probesets 6

Summaries

All 37

Developmental Gene Expression 4

Diseases 1

Gene Ontology 3

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:355648 Abassah-Oppong S, et al., A gene desert required for regulatory control of pleiotropic Shox2 expression and embryonic survival. Nat Commun. 2024 Oct 10;15(1):8793

TSS for Rsrc1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr29428	Chr3:66888685-66888740 (+)	-10 bp
Tssr29429	Chr3:66892980-66893011 (+)	4,273 bp
Tssr29430	Chr3:66893013-66893025 (+)	4,296 bp
Tssr29431	Chr3:66893033-66893073 (+)	4,330 bp
Tssr29432	Chr3:66893280-66893319 (+)	4,577 bp
Tssr29433	Chr3:66999833-66999837 (+)	111,112 bp
Tssr29434	Chr3:66999905-66999915 (+)	111,187 bp
Tssr29435	Chr3:67066488-67066493 (+)	177,768 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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