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Cyp4v3 Gene Detail
Summary
  • Symbol
    Cyp4v3
  • Name
    cytochrome P450, family 4, subfamily v, polypeptide 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2142763
    NCBI Gene: 102294
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:45758838-45786200 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 25.17 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    890 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2142763
 protein coding gene Chr8:45757981-45786253 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033574
 protein coding gene Chr8:44299794-44373921 (-)
A/J MGP_AJ_G0033556
 protein coding gene Chr8:42608415-42674520 (-)
AKR/J MGP_AKRJ_G0033481
 protein coding gene Chr8:43848541-43924890 (-)
BALB/cJ MGP_BALBcJ_G0033553
 protein coding gene Chr8:42777770-42840464 (-)
C3H/HeJ MGP_C3HHeJ_G0033262
 protein coding gene Chr8:44376659-44446996 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034069
 protein coding gene Chr8:45990403-46065795 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031018
 protein coding gene Chr8:38908985-38972647 (-)
CAST/EiJ MGP_CASTEiJ_G0032588
 protein coding gene Chr8:43788904-43864650 (-)
CBA/J MGP_CBAJ_G0033241
 protein coding gene Chr8:47841854-47920278 (-)
DBA/2J MGP_DBA2J_G0033394
 protein coding gene Chr8:42418129-42481693 (-)
FVB/NJ MGP_FVBNJ_G0033335
 protein coding gene Chr8:41916085-41976060 (-)
LP/J MGP_LPJ_G0033482
 protein coding gene Chr8:44322596-44392872 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033380
 protein coding gene Chr8:47921458-47994651 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034087
 protein coding gene Chr8:44014935-44086905 (-)
PWK/PhJ MGP_PWKPhJ_G0032296
 protein coding gene Chr8:41947757-42009636 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032132
 protein coding gene Chr8:43183801-43242313 (-)
WSB/EiJ MGP_WSBEiJ_G0032704
 protein coding gene Chr8:44261944-44335631 (-)



Homology
more
  • Human Ortholog
    CYP4V2, cytochrome P450 family 4 subfamily V member 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYP4V2, cytochrome P450 family 4 subfamily V member 2
  • Synonyms
    BCD, CYP4AH1
  • Links
    NCBI Gene ID: 285440
    neXtProt AC: NX_Q6ZWL3
    UniProt: Q6ZWL3

  • Chr Location
    4q35.1-q35.2; chr4:186191567-186213463 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cyp4v3 mouse models; 1 with human CYP4V2 associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 3 alleles in 3 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit corneoretinal crystal accumulation and systemic dyslipidemia characteristic of Bietti Crystalline Dystrophy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    762
  • Tissues
    32
  • cDNA Data
    44
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 102294 NCBI Gene Model | MGI Sequence Detail 27363 C57BL/6J ±  kb
    transcript NM_133969 RefSeq | MGI Sequence Detail 2898 C57BL/6  
    polypeptide Q9DBW0 UniProt | EBI | MGI Sequence Detail 525 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 45
      cDNA 44
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2142718
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 4
      Diseases 2
      Gene Ontology 4
      Phenotypes 11
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:351964 Shen C, et al., Uncovering the role of ferroptosis in Bietti crystalline dystrophy and potential therapeutic strategies. Cell Commun Signal. 2024 Jul 11;22(1):359
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory