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Dcaf6 Gene Detail
Summary
  • Symbol
    Dcaf6
  • Name
    DDB1 and CUL4 associated factor 6
  • Synonyms
    1200006M05Rik, Iqwd1, NRIP, PC326
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921356
    NCBI Gene: 74106
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:165157069-165288475 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 72.67 cM, cytoband H2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2819 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921356
 protein coding gene Chr1:165156267-165288475 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016692
 protein coding gene Chr1:170810762-170946974 (-)
A/J MGP_AJ_G0016673
 protein coding gene Chr1:163843027-163970458 (-)
AKR/J MGP_AKRJ_G0016639
 protein coding gene Chr1:168803901-168932120 (-)
BALB/cJ MGP_BALBcJ_G0016634
 protein coding gene Chr1:164334175-164465944 (-)
C3H/HeJ MGP_C3HHeJ_G0016458
 protein coding gene Chr1:169020589-169151892 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017095
 protein coding gene Chr1:176541843-176680154 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014804
 protein coding gene Chr1:155751553-155869878 (-)
CAST/EiJ MGP_CASTEiJ_G0016038
 protein coding gene Chr1:168648625-168769504 (-)
CBA/J MGP_CBAJ_G0016433
 protein coding gene Chr1:182825938-182955269 (-)
DBA/2J MGP_DBA2J_G0016539
 protein coding gene Chr1:162735056-162854857 (-)
FVB/NJ MGP_FVBNJ_G0016537
 protein coding gene Chr1:161177147-161294633 (-)
LP/J MGP_LPJ_G0016610
 protein coding gene Chr1:171873152-172004455 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016562
 protein coding gene Chr1:190317121-190458236 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017131
 protein coding gene Chr1:168658540-168792435 (-)
PWK/PhJ MGP_PWKPhJ_G0015824
 protein coding gene Chr1:161934529-162060136 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015611
 protein coding gene Chr1:167525722-167636815 (-)
WSB/EiJ MGP_WSBEiJ_G0016100
 protein coding gene Chr1:168818399-168947389 (-)



Homology
more
  • Human Ortholog
    DCAF6, DDB1 and CUL4 associated factor 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DCAF6, DDB1 and CUL4 associated factor 6
  • Synonyms
    1200006M05Rik, ARCAP, IQWD1, MSTP055, NRIP, PC326
  • Links
    NCBI Gene ID: 55827
    neXtProt AC: NX_Q58WW2
    UniProt: Q58WW2

  • Chr Location
    1q24.2; chr1:167863576-168075843 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit impaired contractility and delayed regeneration with impaired skeletal muscle differentiation and myotube formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    23
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74106 NCBI Gene Model | MGI Sequence Detail 131407 C57BL/6J ±  kb
    transcript NM_028759 RefSeq | MGI Sequence Detail 3306 C57BL/6  
    polypeptide Q9DC22 UniProt | EBI | MGI Sequence Detail 876 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000009100 DDB1- and CUL4-associated factor 6
      (term hierarchy)
    • InterPro Domains
      IPR045151 DDB1- and CUL4-associated factor 8-like
      IPR001680 WD40 repeat
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    • GlyGen
      Q9DC22 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 2
      cDNA 23

      Microarray probesets 2
    References
    more
    • Summaries
      All 39
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory