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Gnai3 Gene Detail
Summary
  • Symbol
    Gnai3
  • Name
    G protein subunit alpha i3
  • Synonyms
    Galphai3
  • Feature Type
    protein coding gene
  • IDs
    MGI:95773
    NCBI Gene: 14679
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:108014596-108053462 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 46.83 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    891 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95773
 protein coding gene Chr3:108014591-108053468 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027766
 protein coding gene Chr3:109640283-109680408 (-)
A/J MGP_AJ_G0027726
 protein coding gene Chr3:106164893-106205044 (-)
AKR/J MGP_AKRJ_G0027691
 protein coding gene Chr3:108751692-108790486 (-)
BALB/cJ MGP_BALBcJ_G0027738
 protein coding gene Chr3:105868355-105907160 (-)
C3H/HeJ MGP_C3HHeJ_G0027468
 protein coding gene Chr3:109092719-109133149 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028182
 protein coding gene Chr3:113734049-113776496 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025520
 protein coding gene Chr3:102318093-102357557 (-)
CAST/EiJ MGP_CASTEiJ_G0026924
 protein coding gene Chr3:108472715-108519029 (-)
CBA/J MGP_CBAJ_G0027443
 protein coding gene Chr3:117600488-117645576 (-)
DBA/2J MGP_DBA2J_G0027585
 protein coding gene Chr3:105348987-105387787 (-)
FVB/NJ MGP_FVBNJ_G0027553
 protein coding gene Chr3:103235292-103275580 (-)
LP/J MGP_LPJ_G0027692
 protein coding gene Chr3:111058951-111099313 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027583
 protein coding gene Chr3:123672416-123713800 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028237
 protein coding gene Chr3:108345198-108384017 (-)
PWK/PhJ MGP_PWKPhJ_G0026650
 protein coding gene Chr3:105096725-105136250 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026470
 protein coding gene Chr3:106480417-106524537 (-)
WSB/EiJ MGP_WSBEiJ_G0027004
 protein coding gene Chr3:108874906-108915852 (-)



Homology
more
  • Human Ortholog
    GNAI3, G protein subunit alpha i3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GNAI3, G protein subunit alpha i3
  • Synonyms
    87U6, ARCND1, ARCODS, HG1A
  • Links
    NCBI Gene ID: 2773
    neXtProt AC: NX_P08754
    UniProt: P08754

  • Chr Location
    1p13.3; chr1:109548615-109600195 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 4 genetic backgrounds
    8 phenotypes from multigenic genotypes
    3 images
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit normal basal cardiac function and beta-adrenergic sensitivity. Mice homozygous for a different knock-out allele exhibit enhanced T cell migration toward CXCR3 agonists.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    749
  • Tissues
    12
  • cDNA Data
    395
  • Literature Summary
    23
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000001 Ensembl Gene Model | MGI Sequence Detail 38867 C57BL/6J ±  kb
    transcript ENSMUST00000000001 Ensembl | MGI Sequence Detail 3262 Not Applicable  
    polypeptide ENSMUSP00000000001 Ensembl | MGI Sequence Detail 354 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000008087 guanine nucleotide-binding protein G(i) subunit alpha-3
      (term hierarchy)
    • PDB
      3AB3
    • InterPro Domains
      IPR001408 G-protein alpha subunit, group I
      IPR011025 G protein alpha subunit, helical insertion
      IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    • GlyGen
      Q9DC51 2 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 399
      cDNA 397
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-10182, MGD-MRK-10185, MGI:2139639, MGI:2139991
    References
    more
    • Summaries
      All 123
      Developmental Gene Expression 23
      Diseases 1
      Gene Ontology 12
      Phenotypes 54
    • Earliest
      J:8848 Jones DT, et al., Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium. J Biol Chem. 1987 Oct 15;262(29):14241-9
    • Latest
      J:338698 Jarysta A, et al., Inhibitory G proteins play multiple roles to polarize sensory hair cell morphogenesis. Elife. 2024 Apr 23;12
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory