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Hmgn3 Gene Detail
Summary
  • Symbol
    Hmgn3
  • Name
    high mobility group nucleosomal binding domain 3
  • Synonyms
    1110002A15Rik, 6330514M13Rik, HMGN3a, HMGN3b, TRIP7
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138069
    NCBI Gene: 94353
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:82992001-83028738 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 45.29 cM, cytoband E3.1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1161 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2138069
 protein coding gene Chr9:82991995-83029411 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035085
 protein coding gene Chr9:83775366-83812894 (-)
A/J MGP_AJ_G0035066
 protein coding gene Chr9:80864809-80901631 (-)
AKR/J MGP_AKRJ_G0034994
 protein coding gene Chr9:82763374-82800075 (-)
BALB/cJ MGP_BALBcJ_G0035054
 protein coding gene Chr9:80512526-80550223 (-)
C3H/HeJ MGP_C3HHeJ_G0034766
 protein coding gene Chr9:83297808-83334927 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035577
 protein coding gene Chr9:86078296-86118805 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032485
 protein coding gene Chr9:79819606-79855027 (-)
CAST/EiJ MGP_CASTEiJ_G0034084
 protein coding gene Chr9:83689483-83726100 (-)
CBA/J MGP_CBAJ_G0034739
 protein coding gene Chr9:89115588-89167502 (-)
DBA/2J MGP_DBA2J_G0034897
 protein coding gene Chr9:80449527-80490648 (-)
FVB/NJ MGP_FVBNJ_G0034840
 protein coding gene Chr9:79607782-79644329 (-)
LP/J MGP_LPJ_G0034978
 protein coding gene Chr9:83972770-84010524 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034882
 protein coding gene Chr9:90543686-90580808 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035598
 protein coding gene Chr9:82938059-82975297 (-)
PWK/PhJ MGP_PWKPhJ_G0033788
 protein coding gene Chr9:80620570-80657865 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033624
 protein coding gene Chr9:83112018-83147761 (-)
WSB/EiJ MGP_WSBEiJ_G0034201
 protein coding gene Chr9:82916923-82957306 (-)



Homology
more
  • Human Ortholog
    HMGN3, high mobility group nucleosomal binding domain 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HMGN3, high mobility group nucleosomal binding domain 3
  • Synonyms
    PNAS-24, PNAS-25, TRIP7
  • Links
    NCBI Gene ID: 9324
    neXtProt AC: NX_Q15651
    UniProt: Q15651

  • Chr Location
    6q14.1; chr6:79201245-79234689 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit impaired glucose tolerance with decreased insulin serum levels and increased glucose serum levels during feeding.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    788
  • Tissues
    67
  • cDNA Data
    24
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000066456 Ensembl Gene Model | MGI Sequence Detail 36738 C57BL/6J ±  kb
    transcript ENSMUST00000187193 Ensembl | MGI Sequence Detail 855 Not Applicable  
    polypeptide ENSMUSP00000140980 Ensembl | MGI Sequence Detail 128 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000029547 high mobility group nucleosome-binding domain-containing protein 3
      (term hierarchy)
    • InterPro Domains
      IPR000079 High mobility group protein HMGN
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 24
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1914636, MGI:1923404, MGI:2143355
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 10
      Gene Ontology 9
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory