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Arpp21 Gene Detail
Summary
  • Symbol
    Arpp21
  • Name
    cyclic AMP-regulated phosphoprotein, 21
  • Synonyms
    0710001E13Rik, ARPP-21, D9Bwg1012e, R3hdm3, Tarpp
  • Feature Type
    protein coding gene
  • IDs
    MGI:107562
    NCBI Gene: 74100
  • Alliance
    gene page
  • Transcription Start Sites
    92 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:111894159-112065006 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 62.46 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4933 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107562
 protein coding gene Chr9:111894159-112065356 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035376
 protein coding gene Chr9:114327206-114512552 (-)
A/J MGP_AJ_G0035357
 protein coding gene Chr9:110127331-110299323 (-)
AKR/J MGP_AKRJ_G0035288
 protein coding gene Chr9:112892772-113067672 (-)
BALB/cJ MGP_BALBcJ_G0035352
 protein coding gene Chr9:109912396-110085669 (-)
C3H/HeJ MGP_C3HHeJ_G0035060
 protein coding gene Chr9:113400592-113571840 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035874
 protein coding gene Chr9:117454201-117640560 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032760
 protein coding gene Chr9:107333805-107500950 (-)
CAST/EiJ MGP_CASTEiJ_G0034366
 protein coding gene Chr9:113216382-113391549 (-)
CBA/J MGP_CBAJ_G0035027
 protein coding gene Chr9:121796321-121975392 (-)
DBA/2J MGP_DBA2J_G0035186
 protein coding gene Chr9:109586312-109756501 (-)
FVB/NJ MGP_FVBNJ_G0035133
 protein coding gene Chr9:108422653-108592721 (-)
LP/J MGP_LPJ_G0035265
 protein coding gene Chr9:114624222-114800072 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035173
 protein coding gene Chr9:123066582-123245047 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035894
 protein coding gene Chr9:113240622-113418421 (-)
PWK/PhJ MGP_PWKPhJ_G0034073
 protein coding gene Chr9:109841362-110020885 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033908
 protein coding gene Chr9:113350612-113533288 (-)
WSB/EiJ MGP_WSBEiJ_G0034487
 protein coding gene Chr9:113119342-113297614 (-)



Homology
more
  • Human Ortholog
    ARPP21, cAMP regulated phosphoprotein 21
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARPP21, cAMP regulated phosphoprotein 21
  • Synonyms
    ARPP-21, R3HDM3, RCS, TARPP
  • Links
    NCBI Gene ID: 10777
    neXtProt AC: NX_Q9UBL0
    UniProt: Q9UBL0

  • Chr Location
    3p22.3; chr3:35638853-35794496 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are viable and display normal brain anatomy and no obvious behavioral or morphological defects. However, in medium spiny neurons from mutant mice, the ability of both M1 and D2 receptor activation to modulate L-type calcium channel currents is enhanced by nearly 2-fold.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    6
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1290
  • Tissues
    76
  • cDNA Data
    21
  • Literature Summary
    8
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032503 Ensembl Gene Model | MGI Sequence Detail 170848 C57BL/6J ±  kb
transcript ENSMUST00000111872 Ensembl | MGI Sequence Detail 3316 Not Applicable  
polypeptide ENSMUSP00000107503 Ensembl | MGI Sequence Detail 809 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 30
    Genomic 1
    cDNA 26
    Primer pair 3

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-34106, MGD-MRK-36134, MGI:106412, MGI:1921350, MGI:1935000, MGI:2143158
References
more
  • Summaries
    All 43
    Developmental Gene Expression 8
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:31637 Ivkovic S, et al., ARPP-21: murine gene structure and promoter identification of a neuronal phosphoprotein enriched in the limbic striatum. Brain Res. 1996 Feb 12;709(1):10-6
  • Latest
    J:342802 Wang N, et al., Mapping brain gene coexpression in daytime transcriptomes unveils diurnal molecular networks and deciphers perturbation gene signatures. Neuron. 2022 Oct 19;110(20):3318-3338.e9
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory