About   Help   FAQ
Tomm20 Gene Detail
Summary
  • Symbol
    Tomm20
  • Name
    translocase of outer mitochondrial membrane 20
  • Synonyms
    1810060K07Rik, MGC:6333, mKIAA0016, TOM20
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915202
    NCBI Gene: 67952
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:127657417-127672594 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 74.64 cM, cytoband E2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    390 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915202
 protein coding gene Chr8:127657414-127672671 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034297
 protein coding gene Chr8:130788137-130807689 (-)
A/J MGP_AJ_G0034276
 protein coding gene Chr8:125364558-125381419 (-)
AKR/J MGP_AKRJ_G0034203
 protein coding gene Chr8:128966248-128988921 (-)
BALB/cJ MGP_BALBcJ_G0034269
 protein coding gene Chr8:125542799-125557926 (-)
C3H/HeJ MGP_C3HHeJ_G0033980
 protein coding gene Chr8:129617317-129632746 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034789
 protein coding gene Chr8:135101570-135119054 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031731
 protein coding gene Chr8:118045579-118060053 (-)
CAST/EiJ MGP_CASTEiJ_G0033307
 protein coding gene Chr8:129802133-129818643 (-)
CBA/J MGP_CBAJ_G0033954
 protein coding gene Chr8:140134750-140152073 (-)
DBA/2J MGP_DBA2J_G0034109
 protein coding gene Chr8:124482664-124497684 (-)
FVB/NJ MGP_FVBNJ_G0034054
 protein coding gene Chr8:123712156-123727960 (-)
LP/J MGP_LPJ_G0034198
 protein coding gene Chr8:130965433-130980663 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034100
 protein coding gene Chr8:142031099-142046440 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034808
 protein coding gene Chr8:129203002-129220017 (-)
PWK/PhJ MGP_PWKPhJ_G0033010
 protein coding gene Chr8:124278206-124293640 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032848
 protein coding gene Chr8:127850988-127865780 (-)
WSB/EiJ MGP_WSBEiJ_G0033425
 protein coding gene Chr8:129953751-129968529 (-)



Homology
more
  • Human Ortholog
    TOMM20, translocase of outer mitochondrial membrane 20
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TOMM20, translocase of outer mitochondrial membrane 20
  • Synonyms
    MAS20, MOM19, TOM20
  • Links
    NCBI Gene ID: 9804
    neXtProt AC: NX_Q15388
    UniProt: Q15388

  • Chr Location
    1q42.3; chr1:235109341-235128837 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    1 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show complete embryonic lethality prior to organogenesis. In vitro, blastocysts do not hatch from the zona pellucida or form outgrowths.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    794
  • Tissues
    31
  • cDNA Data
    13
  • Literature Summary
    34
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000093904 Ensembl Gene Model | MGI Sequence Detail 15178 C57BL/6J ±  kb
transcript ENSMUST00000179857 Ensembl | MGI Sequence Detail 4902 Not Applicable  
polypeptide ENSMUSP00000136493 Ensembl | MGI Sequence Detail 145 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000016532 mitochondrial import receptor subunit TOM20
    (term hierarchy)
  • InterPro Domains
    IPR023392 Mitochondrial outer membrane translocase complex, Tom20 domain superfamily
    IPR002056 Protein import receptor MAS20
    IPR022422 Protein import receptor MAS20, metazoan
Molecular
Reagents
less
  • All nucleic 13
    cDNA 13

    Microarray probesets 5
Other
Accession IDs
less
MGI:3034507
References
more
  • Summaries
    All 92
    Developmental Gene Expression 34
    Gene Ontology 21
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:352092 Wang L, et al., Membrane remodeling by FAM92A1 during brain development regulates neuronal morphology, synaptic function, and cognition. Nat Commun. 2024 Jul 23;15(1):6209
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory