Igtp MGI Mouse Gene Detail - MGI:107729 - interferon gamma induced GTPase

Symbol

Igtp
Name

interferon gamma induced GTPase
Synonyms

Irgm3

Feature Type

protein coding gene
IDs

MGI:107729
NCBI Gene: 16145
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr11:58090382-58098417 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 36.01 cM
Mapping Data

5 experiments

SNPs within 2kb

91 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107729	protein coding gene	Chr11:58090382-58098418 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018345	protein coding gene	Chr11:57879025-57889282 (+)
A/J	MGP_AJ_G0018315	protein coding gene	Chr11:55668831-55694896 (+)
AKR/J	MGP_AKRJ_G0018284	protein coding gene	Chr11:57513894-57522505 (+)
BALB/cJ	MGP_BALBcJ_G0018286	protein coding gene	Chr11:56026686-56034770 (+)
C3H/HeJ	MGP_C3HHeJ_G0018097	protein coding gene	Chr11:57451646-57459878 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018737	protein coding gene	Chr11:59659628-59674125 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016387	protein coding gene	Chr11:53038990-53044751 (+)
CAST/EiJ	MGP_CASTEiJ_G0017662	protein coding gene	Chr11:57544739-57554316 (+)
CBA/J	MGP_CBAJ_G0018072	protein coding gene	Chr11:62410240-62420090 (+)
DBA/2J	MGP_DBA2J_G0018181	protein coding gene	Chr11:55334331-55342303 (+)
FVB/NJ	MGP_FVBNJ_G0018172	protein coding gene	Chr11:55028157-55035916 (+)
LP/J	MGP_LPJ_G0018256	protein coding gene	Chr11:58412365-58420323 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018198	protein coding gene	Chr11:63523880-63532664 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018780	protein coding gene	Chr11:57557790-57567224 (+)
PWK/PhJ	MGP_PWKPhJ_G0017434	protein coding gene	Chr11:55940152-55946299 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017229	protein coding gene	Chr11:57438778-57446870 (+)
WSB/EiJ	MGP_WSBEiJ_G0017709	protein coding gene	Chr11:57187697-57198837 (+)

Human Ortholog

IRGM, immunity related GTPase M

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IRGM, immunity related GTPase M
Synonyms

IBD19, IFI1, IRGM1, LRG-47, LRG47
Links

HGNC:29597

NCBI Gene ID: 345611

neXtProt AC: NX_A1A4Y4

UniProt: A1A4Y4
Chr Location

5q33.1; chr5:150846521-150902402 (+) GRCh38

MGI Vertebrate Homology

Igtp stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: IRGM
Gene Tree

Igtp

Diseases

2 with human IRGM associations

				Human Disease	Mouse Models
				inflammatory bowel disease 19 IDs inflammatory bowel disease 19 DOID:0110890 MESH:C567372 OMIM:612278
				tuberculosis IDs tuberculosis DOID:399 DOID:10096 DOID:12688 DOID:12691 DOID:415 DOID:9901 DOID:9902 MESH:D014375 UMLS_CUI:C0041295

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
35 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

4
Targeted

3
Genomic Mutations

1 involving Igtp
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit impaired cell-autonomous Toxoplasma killing.

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All GO Annotations

66
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

133
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

52
RefSeq

2
UniProt

5
CCDS

CCDS24725.1

Ensembl

ENSMUSG00000078853 (Evidence)
NCBI Gene

16145

			Length	Strain/Species	Flank
genomic	ENSMUSG00000078853	Ensembl Gene Model \| MGI Sequence Detail	8036	C57BL/6J	± kb
transcript	ENSMUST00000035266	Ensembl \| MGI Sequence Detail	2022	Not Applicable
polypeptide	ENSMUSP00000047356	Ensembl \| MGI Sequence Detail	423	Not Applicable

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UniProt

5 Sequences
EC

3.6.5.-
InterPro Domains

IPR051515 Immunity-related GTPase

IPR007743 Immunity-related GTPases-like

IPR030385 IRG-type guanine nucleotide-binding (G) domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 134

cDNA 133

Primer pair 1

Microarray probesets 3

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MGD-MRK-36305, MGI:2144580

Summaries

All 72

Developmental Gene Expression 2

Gene Ontology 14

Phenotypes 35
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:333980 Christgen S, et al., The IFN-inducible GTPase IRGB10 regulates viral replication and inflammasome activation during influenza A virus infection in mice. Eur J Immunol. 2022 Feb;52(2):285-296

TSS for Igtp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101691	Chr11:58090553-58090581 (+)	185 bp
Tssr101692	Chr11:58092176-58092197 (+)	1,805 bp
Tssr101693	Chr11:58092295-58092327 (+)	1,929 bp
Tssr101694	Chr11:58092332-58092364 (+)	1,966 bp
Tssr101695	Chr11:58093353-58093365 (+)	2,977 bp
Tssr101696	Chr11:58093400-58093410 (+)	3,023 bp
Tssr101697	Chr11:58093442-58093454 (+)	3,066 bp
Tssr101698	Chr11:58094091-58094112 (+)	3,720 bp
Tssr101699	Chr11:58095764-58095783 (+)	5,392 bp
Tssr101700	Chr11:58095888-58095921 (+)	5,523 bp
Tssr101701	Chr11:58095928-58095950 (+)	5,557 bp
Tssr101702	Chr11:58096922-58096941 (+)	6,550 bp
Tssr101703	Chr11:58096943-58096954 (+)	6,567 bp
Tssr101704	Chr11:58097517-58097543 (+)	7,148 bp
Tssr101705	Chr11:58097764-58097775 (+)	7,388 bp
Tssr101706	Chr11:58097793-58097802 (+)	7,416 bp
Tssr101707	Chr11:58098139-58098166 (+)	7,771 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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