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Xylt2 Gene Detail
Summary
  • Symbol
    Xylt2
  • Name
    xylosyltransferase II
  • Synonyms
    E030002B02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444797
    NCBI Gene: 217119
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:94554677-94568341 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 58.90 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    375 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444797
 protein coding gene Chr11:94554671-94568341 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018966
 protein coding gene Chr11:96776022-96789725 (-)
A/J MGP_AJ_G0018934
 protein coding gene Chr11:92893588-92907339 (-)
AKR/J MGP_AKRJ_G0018904
 protein coding gene Chr11:95783321-95797079 (-)
BALB/cJ MGP_BALBcJ_G0018907
 protein coding gene Chr11:93342730-93356394 (-)
C3H/HeJ MGP_C3HHeJ_G0018721
 protein coding gene Chr11:95866919-95880686 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019359
 protein coding gene Chr11:99812919-99826583 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016990
 protein coding gene Chr11:90384734-90398714 (-)
CAST/EiJ MGP_CASTEiJ_G0018276
 protein coding gene Chr11:96594575-96608243 (-)
CBA/J MGP_CBAJ_G0018692
 protein coding gene Chr11:103936704-103950475 (-)
DBA/2J MGP_DBA2J_G0018800
 protein coding gene Chr11:92473953-92487617 (-)
FVB/NJ MGP_FVBNJ_G0018789
 protein coding gene Chr11:91891822-91905558 (-)
LP/J MGP_LPJ_G0018870
 protein coding gene Chr11:97315339-97330135 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018816
 protein coding gene Chr11:103938316-103951980 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019399
 protein coding gene Chr11:96023015-96036679 (-)
PWK/PhJ MGP_PWKPhJ_G0018046
 protein coding gene Chr11:93408108-93421916 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017836
 protein coding gene Chr11:95691719-95705476 (-)
WSB/EiJ MGP_WSBEiJ_G0018325
 protein coding gene Chr11:95895055-95908719 (-)



Homology
more
  • Human Ortholog
    XYLT2, xylosyltransferase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    XYLT2, xylosyltransferase 2
  • Synonyms
    PXYLT2, SOS, XT2, XT-II, xylT-II
  • Links
    NCBI Gene ID: 64132
    neXtProt AC: NX_Q9H1B5
    UniProt: Q9H1B5

  • Chr Location
    17q21.33; chr17:50346126-50363138 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Xylt2 mouse models; 1 with human XYLT2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    5 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele lack most liver proteoglycans and develop many aspects of polycystic liver and kidney disease, including biliary tract hyperplasia, liver fibrosis, biliary cysts, renal tubule dilation, basement membrane abnormalities and hydronephrosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    830
  • Tissues
    97
  • cDNA Data
    112
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020868 Ensembl Gene Model | MGI Sequence Detail 13665 C57BL/6J ±  kb
    transcript ENSMUST00000116349 Ensembl | MGI Sequence Detail 3442 Not Applicable  
    polypeptide ENSMUSP00000112052 Ensembl | MGI Sequence Detail 865 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 112
      cDNA 112

      Microarray probesets 2
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 8
      Phenotypes 14
    • Earliest
      J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
    • Latest
      J:295904 Mohan RA, et al., T-box transcription factor 3 governs a transcriptional program for the function of the mouse atrioventricular conduction system. Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18617-18626
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory