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Clstn1 Gene Detail
Summary
  • Symbol
    Clstn1
  • Name
    calsyntenin 1
  • Synonyms
    1810034E21Rik, alcadein alpha, calsyntenin-1, Cst-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929895
    NCBI Gene: 65945
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:149670925-149733356 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 79.91 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    443 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929895
 protein coding gene Chr4:149670536-149733356 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029143
 protein coding gene Chr4:153448506-153525449 (+)
A/J MGP_AJ_G0029108
 protein coding gene Chr4:147043532-147111546 (+)
AKR/J MGP_AKRJ_G0029056
 protein coding gene Chr4:151065378-151147808 (+)
BALB/cJ MGP_BALBcJ_G0029124
 protein coding gene Chr4:147543029-147608691 (+)
C3H/HeJ MGP_C3HHeJ_G0028845
 protein coding gene Chr4:151626192-151701484 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029573
 protein coding gene Chr4:158987697-159063569 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026819
 protein coding gene Chr4:139454389-139526553 (+)
CAST/EiJ MGP_CASTEiJ_G0028258
 protein coding gene Chr4:148860274-148939968 (+)
CBA/J MGP_CBAJ_G0028807
 protein coding gene Chr4:163646358-163721187 (+)
DBA/2J MGP_DBA2J_G0028956
 protein coding gene Chr4:147143075-147204775 (+)
FVB/NJ MGP_FVBNJ_G0028920
 protein coding gene Chr4:146260458-146332320 (+)
LP/J MGP_LPJ_G0029046
 protein coding gene Chr4:153364681-153452916 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028947
 protein coding gene Chr4:166881024-166958722 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029605
 protein coding gene Chr4:151566986-151637593 (+)
PWK/PhJ MGP_PWKPhJ_G0027978
 protein coding gene Chr4:143150080-143221772 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027812
 protein coding gene Chr4:145815718-145894213 (+)
WSB/EiJ MGP_WSBEiJ_G0028338
 protein coding gene Chr4:151719950-151792219 (+)



Homology
more
  • Human Ortholog
    CLSTN1, calsyntenin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLSTN1, calsyntenin 1
  • Synonyms
    ALC-ALPHA, alcalpha1, alcalpha2, CDHR12, CST-1, CSTN1, PIK3CD, XB31alpha
  • Links
    NCBI Gene ID: 22883
    neXtProt AC: NX_O94985
    UniProt: O94985

  • Chr Location
    1p36.22; chr1:9728926-9824526 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Juvenile mice homozygous for a null allele show reduced basal excitatory synaptic transmission, abnormal excitatory postsynaptic currents, enhanced NMDA receptor-dependent long term potentiation, and delayed dendritic spine maturation in CA1 hippocampal pyramidal cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    780
  • Tissues
    61
  • cDNA Data
    208
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039953 Ensembl Gene Model | MGI Sequence Detail 62432 C57BL/6J ±  kb
    transcript ENSMUST00000039144 Ensembl | MGI Sequence Detail 3319 Not Applicable  
    polypeptide ENSMUSP00000036962 Ensembl | MGI Sequence Detail 979 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 213
      cDNA 209
      Primer pair 2
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1921573
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 8
      Gene Ontology 11
      Phenotypes 17
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:353365 Honda K, et al., Suppression of the amyloidogenic metabolism of APP and the accumulation of Abeta by alcadein alpha in the brain during aging. Sci Rep. 2024 Aug 9;14(1):18471
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory