Inpp4a MGI Mouse Gene Detail - MGI:1931123 - inositol polyphosphate-4-phosphatase, type I

Symbol

Inpp4a
Name

inositol polyphosphate-4-phosphatase, type I
Synonyms

107kDa

Feature Type

protein coding gene
IDs

MGI:1931123
NCBI Gene: 269180
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:37338946-37449817 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 15.46 cM
Mapping Data

2 experiments

SNPs within 2kb

2640 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1931123	protein coding gene	Chr1:37338908-37449821 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0015936	protein coding gene	Chr1:35910507-36023572 (+)
A/J	MGP_AJ_G0015920	protein coding gene	Chr1:34926316-35037526 (+)
AKR/J	MGP_AKRJ_G0015875	protein coding gene	Chr1:35413888-35526676 (+)
BALB/cJ	MGP_BALBcJ_G0015874	protein coding gene	Chr1:34599276-34710431 (+)
C3H/HeJ	MGP_C3HHeJ_G0015707	protein coding gene	Chr1:35640144-35750780 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016327	protein coding gene	Chr1:37498132-37612163 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014049	protein coding gene	Chr1:31947360-32057027 (+)
CAST/EiJ	MGP_CASTEiJ_G0015288	protein coding gene	Chr1:35494884-35609798 (+)
CBA/J	MGP_CBAJ_G0015679	protein coding gene	Chr1:38512151-38625651 (+)
DBA/2J	MGP_DBA2J_G0015780	protein coding gene	Chr1:34251432-34361854 (+)
FVB/NJ	MGP_FVBNJ_G0015782	protein coding gene	Chr1:33775583-33895423 (+)
LP/J	MGP_LPJ_G0015850	protein coding gene	Chr1:36260753-36373413 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015802	protein coding gene	Chr1:40713681-40827194 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016374	protein coding gene	Chr1:35473294-35586288 (+)
PWK/PhJ	MGP_PWKPhJ_G0015071	protein coding gene	Chr1:34012919-34125355 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014853	protein coding gene	Chr1:35403367-35522941 (+)
WSB/EiJ	MGP_WSBEiJ_G0015350	protein coding gene	Chr1:35423849-35540082 (+)

Human Ortholog

INPP4A, inositol polyphosphate-4-phosphatase type I A

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

INPP4A, inositol polyphosphate-4-phosphatase type I A
Synonyms

INPP4, TVAS1
Links

HGNC:6074

NCBI Gene ID: 3631

neXtProt AC: NX_Q96PE3

UniProt: Q96PE3
Chr Location

2q11.2; chr2:98444587-98594392 (+) GRCh38

MGI Vertebrate Homology

Inpp4a stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: INPP4A
Gene Tree

Inpp4a

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Phenotype Summary

20 phenotypes from 2 alleles in 3 genetic backgrounds
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

6
Spontaneous

1
Targeted

5
Genomic Mutations

1 involving Inpp4a
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

55 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a spontaneous mutation exhibit small size, ataxia, loss of cerebellar and hippocampal CA1 neurons, and death by 24 days of age from seizures and/or malnutrition.

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All GO Annotations

25
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

898
Tissues

154
cDNA Data

6
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase inpp4a

ZFIN inpp4ab

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All Sequences

106
RefSeq

40
UniProt

13
CCDS

CCDS35539.1, CCDS35540.1, CCDS69879.1, CCDS78570.1, CCDS87820.1

Ensembl

ENSMUSG00000026113 (Evidence)
NCBI Gene

269180

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026113	Ensembl Gene Model \| MGI Sequence Detail	110872	C57BL/6J	± kb
transcript	ENSMUST00000137266	Ensembl \| MGI Sequence Detail	2934	Not Applicable
polypeptide	ENSMUSP00000121803	Ensembl \| MGI Sequence Detail	977	Not Applicable

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UniProt

13 Sequences
Protein Ontology

PR:000009045 inositol polyphosphate-4-phosphatase type I A

(term hierarchy)
EC

3.1.3.66
InterPro Domains

IPR000008 C2 domain

IPR035892 C2 domain superfamily

IPR039034 Inositol 3,4-bisphosphate 4-phosphatase
GlyGen

Q9EPW0 5 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (2 sites)

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All nucleic 19

Genomic 6

cDNA 9

Primer pair 4

Microarray probesets 2

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MGI:2138728

Summaries

All 46

Developmental Gene Expression 6

Gene Ontology 8

Phenotypes 19
Earliest

J:66416 Vyas P, et al., Inositol polyphosphate 4-phosphatase type I regulates cell growth downstream of transcription factor GATA-1. Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13696-701
Latest

J:339153 Tran DM, et al., Attenuated cerebellar phenotypes in Inpp4a truncation mutants with preserved phosphatase activity. Dis Model Mech. 2023 Jul 1;16(7)

TSS for Inpp4a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6305	Chr1:37338940-37338951 (+)	0 bp
Tssr6306	Chr1:37338963-37339018 (+)	45 bp
Tssr6307	Chr1:37439449-37439453 (+)	100,505 bp
Tssr6308	Chr1:37447908-37447953 (+)	108,985 bp
Tssr6309	Chr1:37448699-37448703 (+)	109,755 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24