Fbxl12 MGI Mouse Gene Detail - MGI:1354738 - F-box and leucine-rich repeat protein 12

Symbol

Fbxl12
Name

F-box and leucine-rich repeat protein 12
Synonyms

3110048D16Rik

Feature Type

protein coding gene
IDs

MGI:1354738
NCBI Gene: 30843
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr9:20549045-20556064 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 7.59 cM, cytoband A3
Mapping Data

2 experiments

SNPs within 2kb

245 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1354738	protein coding gene	Chr9:20529414-20556064 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0034422	protein coding gene	Chr9:17765012-17788047 (-)
A/J	MGP_AJ_G0034400	protein coding gene	Chr9:17483406-17507510 (-)
AKR/J	MGP_AKRJ_G0034327	protein coding gene	Chr9:17801930-17825098 (-)
BALB/cJ	MGP_BALBcJ_G0034391	protein coding gene	Chr9:17390230-17411627 (-)
C3H/HeJ	MGP_C3HHeJ_G0034103	protein coding gene	Chr9:18117015-18138851 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0034912	protein coding gene	Chr9:18488643-18509078 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031842	protein coding gene	Chr9:16623386-16643754 (-)
CAST/EiJ	MGP_CASTEiJ_G0033426	protein coding gene	Chr9:17925097-17948784 (-)
CBA/J	MGP_CBAJ_G0034076	protein coding gene	Chr9:19198770-19222030 (-)
DBA/2J	MGP_DBA2J_G0034235	protein coding gene	Chr9:17483388-17504047 (-)
FVB/NJ	MGP_FVBNJ_G0034178	protein coding gene	Chr9:16983241-17003751 (-)
LP/J	MGP_LPJ_G0034320	protein coding gene	Chr9:17947003-17975026 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034221	protein coding gene	Chr9:20836553-20859214 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034932	protein coding gene	Chr9:17749507-17772206 (-)
PWK/PhJ	MGP_PWKPhJ_G0033132	protein coding gene	Chr9:17444224-17464961 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0032966	protein coding gene	Chr9:17789315-17810907 (-)
WSB/EiJ	MGP_WSBEiJ_G0033541	protein coding gene	Chr9:17480167-17502513 (-)

Human Ortholog

FBXL12, F-box and leucine rich repeat protein 12

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FBXL12, F-box and leucine rich repeat protein 12
Synonyms

Fbl12
Links

HGNC:13611

NCBI Gene ID: 54850

neXtProt AC: NX_Q9NXK8

UniProt: Q9NXK8
Chr Location

19p13.2; chr19:9810267-9827816 (-) GRCh38

MGI Vertebrate Homology

Fbxl12 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: FBXL12
Gene Tree

Fbxl12

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Phenotype Summary

10 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

1
Gene trapped

1
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit partial postnatal lethality, growth retardation, small placenta, absent gastric milk in mice that die and abnormal placental.

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All GO Annotations

4
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

737
Tissues

10
cDNA Data

13
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fbxl12

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All Sequences

76
RefSeq

14
UniProt

5
CCDS

CCDS22880.1, CCDS22881.1, CCDS90505.1

Ensembl

ENSMUSG00000066892 (Evidence)
NCBI Gene

30843

			Length	Strain/Species	Flank
genomic	30843	NCBI Gene Model \| MGI Sequence Detail	7020	C57BL/6J	± kb
transcript	NM_013911	RefSeq \| MGI Sequence Detail	2126	C57BL/6
polypeptide	Q9EPX5	UniProt \| EBI \| MGI Sequence Detail	326	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000007370 F-box/LRR-repeat protein 12

(term hierarchy)
InterPro Domains

IPR001810 F-box domain

IPR036047 F-box-like domain superfamily

IPR032675 Leucine-rich repeat domain superfamily

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All nucleic 15

cDNA 14

Primer pair 1

Microarray probesets 5

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MGI:1920456

Summaries

All 29

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 7
Earliest

J:58149 Winston JT, et al., A family of mammalian F-box proteins. Curr Biol. 1999 Oct 21;9(20):1180-2
Latest

J:280728 Zhao B, et al., Notch and the pre-TCR coordinate thymocyte proliferation by induction of the SCF subunits Fbxl1 and Fbxl12. Nat Immunol. 2019 Oct;20(10):1381-1392

TSS for Fbxl12:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr88320	Chr9:20556572-20556588 (-)	-516 bp
Tssr88319	Chr9:20556022-20556085 (-)	10 bp
Tssr88318	Chr9:20554493-20554511 (-)	1,562 bp
Tssr88317	Chr9:20554459-20554492 (-)	1,588 bp
Tssr88316	Chr9:20553920-20553933 (-)	2,137 bp
Tssr88315	Chr9:20553882-20553902 (-)	2,172 bp
Tssr88314	Chr9:20553807-20553832 (-)	2,244 bp
Tssr88313	Chr9:20553779-20553802 (-)	2,273 bp
Tssr88312	Chr9:20553576-20553618 (-)	2,467 bp
Tssr88311	Chr9:20551693-20551697 (-)	4,369 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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