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Ghrl Gene Detail
Summary
  • Symbol
    Ghrl
  • Name
    ghrelin
  • Synonyms
    2210006E23Rik, Ghr, m46, MTLRP, MTLRPAP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930008
    NCBI Gene: 58991
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:113693080-113696841 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 52.84 cM, cytoband E3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    167 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1930008
 protein coding gene Chr6:113693080-113696872 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031136
 protein coding gene Chr6:116262419-116266178 (-)
A/J MGP_AJ_G0031105
 protein coding gene Chr6:111796320-111800073 (-)
AKR/J MGP_AKRJ_G0031036
 protein coding gene Chr6:114802470-114806193 (-)
BALB/cJ MGP_BALBcJ_G0031116
 protein coding gene Chr6:111741671-111745448 (-)
C3H/HeJ MGP_C3HHeJ_G0030592
 protein coding gene Chr6:69490230-69493953 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031575
 protein coding gene Chr6:119259734-119263507 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028739
 protein coding gene Chr6:108823401-108827115 (-)
CAST/EiJ MGP_CASTEiJ_G0030223
 protein coding gene Chr6:115261522-115265247 (-)
CBA/J MGP_CBAJ_G0030802
 protein coding gene Chr6:123973211-123976934 (-)
DBA/2J MGP_DBA2J_G0030955
 protein coding gene Chr6:110876863-110880576 (-)
FVB/NJ MGP_FVBNJ_G0030909
 protein coding gene Chr6:109881274-109885005 (-)
LP/J MGP_LPJ_G0031035
 protein coding gene Chr6:116285640-116289381 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030943
 protein coding gene Chr6:128216116-128219847 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031602
 protein coding gene Chr6:114823951-114827678 (-)
PWK/PhJ MGP_PWKPhJ_G0029939
 protein coding gene Chr6:109839024-109842822 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029767
 protein coding gene Chr6:113629480-113633360 (-)
WSB/EiJ MGP_WSBEiJ_G0030307
 protein coding gene Chr6:115196729-115200471 (-)



Homology
more
  • Human Ortholog
    GHRL, ghrelin and obestatin prepropeptide
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GHRL, ghrelin and obestatin prepropeptide
  • Synonyms
    MTLRP
  • Links
    NCBI Gene ID: 51738
    neXtProt AC: NX_Q9UBU3
    UniProt: Q9UBU3

  • Chr Location
    3p25.3; chr3:10285666-10292947 (-)  GRCh38
Human Diseases
more
  • Diseases
    5 with human GHRL associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 5 alleles in 6 genetic backgrounds
    82 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for most disruptions in this gene display no phenotypic abnormalities on a regular diet and increased utilization of fat as an energy substrate on a high fat diet. Mice homozygous for one allele display age-dependent changes in stimulated food intake and metabolism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    137
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    862
  • Tissues
    114
  • cDNA Data
    12
  • Literature Summary
    93
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000064177 Ensembl Gene Model | MGI Sequence Detail 3762 C57BL/6J ±  kb
    transcript ENSMUST00000064993 Ensembl | MGI Sequence Detail 527 Not Applicable  
    polypeptide ENSMUSP00000069567 Ensembl | MGI Sequence Detail 117 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 13
      Primer pair 8
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1914343
    References
    more
    • Summaries
      All 291
      Developmental Gene Expression 93
      Gene Ontology 19
      Phenotypes 82
    • Earliest
      J:63705 Tomasetto C, et al., Identification and characterization of a novel gastric peptide hormone: the motilin-related peptide. Gastroenterology. 2000 Aug;119(2):395-405
    • Latest
      J:352077 Kane E, et al., MicroRNA-7 regulates endocrine progenitor delamination and endocrine cell mass in developing pancreatic islets. iScience. 2024 Jul 19;27(7):110332
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory