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Ern1 Gene Detail
Summary
  • Symbol
    Ern1
  • Name
    endoplasmic reticulum to nucleus signalling 1
  • Synonyms
    9030414B18Rik, Ire1a, Ire1alpha, Ire1p
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930134
    NCBI Gene: 78943
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:106285476-106378678 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 69.14 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2172 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1930134
 protein coding gene Chr11:106285474-106378701 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019308
 protein coding gene Chr11:109685701-109787385 (-)
A/J MGP_AJ_G0019276
 protein coding gene Chr11:105018457-105114379 (-)
AKR/J MGP_AKRJ_G0019245
 protein coding gene Chr11:108150065-108245348 (-)
BALB/cJ MGP_BALBcJ_G0019250
 protein coding gene Chr11:105428029-105523464 (-)
C3H/HeJ MGP_C3HHeJ_G0019059
 protein coding gene Chr11:108439479-108539473 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019700
 protein coding gene Chr11:113041732-113159799 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017324
 protein coding gene Chr11:102295791-102389777 (-)
CAST/EiJ MGP_CASTEiJ_G0018612
 protein coding gene Chr11:109503825-109614140 (-)
CBA/J MGP_CBAJ_G0019028
 protein coding gene Chr11:117750347-117860616 (-)
DBA/2J MGP_DBA2J_G0019140
 protein coding gene Chr11:104487878-104584145 (-)
FVB/NJ MGP_FVBNJ_G0019131
 protein coding gene Chr11:103994154-104087670 (-)
LP/J MGP_LPJ_G0019210
 protein coding gene Chr11:110129826-110226809 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019161
 protein coding gene Chr11:117019442-117126310 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019737
 protein coding gene Chr11:108639867-108736965 (-)
PWK/PhJ MGP_PWKPhJ_G0018377
 protein coding gene Chr11:105585244-105679790 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018168
 protein coding gene Chr11:108417445-108516972 (-)
WSB/EiJ MGP_WSBEiJ_G0018663
 protein coding gene Chr11:108607823-108718203 (-)



Homology
more
  • Human Ortholog
    ERN1, endoplasmic reticulum to nucleus signaling 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ERN1, endoplasmic reticulum to nucleus signaling 1
  • Synonyms
    hIRE1p, IRE1, IRE1a, IRE1P
  • Links
    NCBI Gene ID: 2081
    neXtProt AC: NX_O75460
    UniProt: O75460

  • Chr Location
    17q23.3; chr17:64039080-64130819 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ERN1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 6 alleles in 7 genetic backgrounds
    1 phenotype from multigenic genotypes
    107 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for null mutations display embryonic lethality during organogenesis. Homozygous mice may also display decreased embryo size, impaired hematopoiesis, and/or placental abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    89
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    799
  • Tissues
    45
  • cDNA Data
    63
  • Literature Summary
    31
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020715 Ensembl Gene Model | MGI Sequence Detail 93203 C57BL/6J ±  kb
    transcript ENSMUST00000001059 Ensembl | MGI Sequence Detail 6946 Not Applicable  
    polypeptide ENSMUSP00000001059 Ensembl | MGI Sequence Detail 977 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 74
      cDNA 66
      Primer pair 7
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1918791, MGI:2144086, MGI:2144679
    References
    more
    • Summaries
      All 236
      Developmental Gene Expression 31
      Gene Ontology 24
      Phenotypes 107
    • Earliest
      J:57921 Wang XZ, et al., Cloning of mammalian Ire1 reveals diversity in the ER stress responses. EMBO J. 1998 Oct 1;17(19):5708-17
    • Latest
      J:353791 Xu L, et al., Context-dependent roles of mitochondrial LONP1 in orchestrating the balance between airway progenitor versus progeny cells. Cell Stem Cell. 2024 Aug 16;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory