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Strn3 Gene Detail
Summary
  • Symbol
    Strn3
  • Name
    striatin, calmodulin binding protein 3
  • Synonyms
    SG2NA
  • Feature Type
    protein coding gene
  • IDs
    MGI:2151064
    NCBI Gene: 94186
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:51656415-51738680 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 22.11 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1603 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2151064
 protein coding gene Chr12:51655324-51743942 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019725
 protein coding gene Chr12:50407913-50498622 (-)
A/J MGP_AJ_G0019687
 protein coding gene Chr12:48633778-48718844 (-)
AKR/J MGP_AKRJ_G0019658
 protein coding gene Chr12:50089464-50178910 (-)
BALB/cJ MGP_BALBcJ_G0019665
 protein coding gene Chr12:48913743-49000429 (-)
C3H/HeJ MGP_C3HHeJ_G0019468
 protein coding gene Chr12:50197366-50284370 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020113
 protein coding gene Chr12:51975918-52066844 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017736
 protein coding gene Chr12:47027271-47105914 (-)
CAST/EiJ MGP_CASTEiJ_G0019021
 protein coding gene Chr12:45225848-45318610 (-)
CBA/J MGP_CBAJ_G0019440
 protein coding gene Chr12:53760197-53845865 (-)
DBA/2J MGP_DBA2J_G0019554
 protein coding gene Chr12:48488275-48579455 (-)
FVB/NJ MGP_FVBNJ_G0019543
 protein coding gene Chr12:47931759-48015199 (-)
LP/J MGP_LPJ_G0019626
 protein coding gene Chr12:50445842-50534419 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019579
 protein coding gene Chr12:55373988-55467049 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020151
 protein coding gene Chr12:49585146-49670639 (-)
PWK/PhJ MGP_PWKPhJ_G0018788
 protein coding gene Chr12:43064345-43151351 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018582
 protein coding gene Chr12:44174128-44263660 (-)
WSB/EiJ MGP_WSBEiJ_G0019072
 protein coding gene Chr12:50064966-50153079 (-)



Homology
more
  • Human Ortholog
    STRN3, striatin 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STRN3, striatin 3
  • Synonyms
    PPP2R6B, S/G2NA, SG2NA
  • Links
    NCBI Gene ID: 29966
    neXtProt AC: NX_Q13033
    UniProt: Q13033

  • Chr Location
    14q12; chr14:30893799-31026401 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    1 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased embryo size, absent primitive node and head folds, failure to gastrulate, and complete lethality between implantation and placentation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    775
  • Tissues
    54
  • cDNA Data
    9
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020954 Ensembl Gene Model | MGI Sequence Detail 82266 C57BL/6J ±  kb
    transcript ENSMUST00000013130 Ensembl | MGI Sequence Detail 3046 Not Applicable  
    polypeptide ENSMUSP00000013130 Ensembl | MGI Sequence Detail 796 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 16
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:351328 Cull JJ, et al., Striatin plays a major role in angiotensin II-induced cardiomyocyte and cardiac hypertrophy in mice in vivo. Clin Sci (Lond). 2024 May 22;138(10):573-597
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory