Gmfg MGI Mouse Gene Detail - MGI:1927135 - glia maturation factor, gamma

Symbol

Gmfg
Name

glia maturation factor, gamma
Synonyms

0610039G16Rik, 2310057N07Rik

Feature Type

protein coding gene
IDs

MGI:1927135
NCBI Gene: 63986
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr7:28136894-28147655 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 16.76 cM
Mapping Data

1 experiment

SNPs within 2kb

323 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1927135	protein coding gene	Chr7:28136872-28147658 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031946	protein coding gene	Chr7:27224596-27240264 (+)
A/J	MGP_AJ_G0031925	protein coding gene	Chr7:26562218-26574416 (+)
AKR/J	MGP_AKRJ_G0031856	protein coding gene	Chr7:27237839-27250644 (+)
BALB/cJ	MGP_BALBcJ_G0031931	protein coding gene	Chr7:26720050-26731738 (+)
C3H/HeJ	MGP_C3HHeJ_G0031653	protein coding gene	Chr7:27617557-27632795 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032396	protein coding gene	Chr7:28099216-28111074 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029448	protein coding gene	Chr7:27635390-27645872 (+)
CAST/EiJ	MGP_CASTEiJ_G0030988	protein coding gene	Chr7:20922458-20943182 (+)
CBA/J	MGP_CBAJ_G0031616	protein coding gene	Chr7:29361860-29376456 (+)
DBA/2J	MGP_DBA2J_G0031769	protein coding gene	Chr7:26324448-26335204 (+)
FVB/NJ	MGP_FVBNJ_G0031726	protein coding gene	Chr7:26393666-26405884 (+)
LP/J	MGP_LPJ_G0031850	protein coding gene	Chr7:27547696-27558873 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031761	protein coding gene	Chr7:28858240-28884055 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032426	protein coding gene	Chr7:26725932-26738731 (+)
PWK/PhJ	MGP_PWKPhJ_G0030711	protein coding gene	Chr7:21327264-21339308 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030546	protein coding gene	Chr7:17727712-17739178 (+)
WSB/EiJ	MGP_WSBEiJ_G0031095	protein coding gene	Chr7:27058081-27081818 (+)

Human Ortholog

GMFG, glia maturation factor gamma

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GMFG, glia maturation factor gamma
Synonyms

GMF-GAMMA
Links

HGNC:4374

NCBI Gene ID: 9535

neXtProt AC: NX_O60234

UniProt: O60234
Chr Location

19q13.2; chr19:39328353-39342372 (-) GRCh38

MGI Vertebrate Homology

Gmfg stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GMFG
Protein SuperFamily

GMF-beta
Gene Tree

Gmfg

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

4
Gene trapped

4
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display impaired marginal zone B cell functions.

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All GO Annotations

10
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

740
Tissues

25
cDNA Data

11
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gmfg

ZFIN gmfg

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All Sequences

55
RefSeq

10
UniProt

5
CCDS

CCDS39859.1, CCDS39860.1, CCDS80687.1

Ensembl

ENSMUSG00000060791 (Evidence)
NCBI Gene

63986

			Length	Strain/Species	Flank
genomic	63986	NCBI Gene Model \| MGI Sequence Detail	10762	C57BL/6J	± kb
transcript	NM_022024	RefSeq \| MGI Sequence Detail	2319	C57BL/6
polypeptide	Q9ERL7	UniProt \| EBI \| MGI Sequence Detail	142	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000008071 glia maturation factor gamma

(term hierarchy)
PDB

1VKK, 1WFS, 4JD2
InterPro Domains

IPR002108 Actin-depolymerising factor homology domain

IPR029006 ADF-H/Gelsolin-like domain superfamily

IPR011171 Glia maturation factor

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All nucleic 13

cDNA 11

Primer pair 1

Other 1

Microarray probesets 5

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MGI:1914927, MGI:1923721, MGI:2141393

Summaries

All 39

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Gmfg:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr65477	Chr7:28136872-28136911 (+)	-2 bp
Tssr65478	Chr7:28140356-28140370 (+)	3,469 bp
Tssr65479	Chr7:28140371-28140443 (+)	3,513 bp
Tssr65480	Chr7:28140451-28140460 (+)	3,562 bp
Tssr2167	Chr7:28140566-28140581 (+)	3,680 bp
Tssr65481	Chr7:28142502-28142549 (+)	5,632 bp
Tssr65482	Chr7:28143378-28143387 (+)	6,489 bp
Tssr65483	Chr7:28144205-28144275 (+)	7,346 bp
Tssr65484	Chr7:28144364-28144394 (+)	7,485 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24