Icam4 MGI Mouse Gene Detail - MGI:1925619 - intercellular adhesion molecule 4, Landsteiner-Wiener blood group

Symbol

Icam4
Name

intercellular adhesion molecule 4, Landsteiner-Wiener blood group
Synonyms

1810015M19Rik, Cd242

Feature Type

protein coding gene
IDs

MGI:1925619
NCBI Gene: 78369
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr9:20940728-20941892 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 7.69 cM, cytoband A3
Mapping Data

4 experiments

SNPs within 2kb

73 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1925619	protein coding gene	Chr9:20940669-20941892 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034436	protein coding gene	Chr9:18210529-18211687 (+)
A/J	MGP_AJ_G0034414	protein coding gene	Chr9:17908401-17909559 (+)
AKR/J	MGP_AKRJ_G0034341	protein coding gene	Chr9:18230207-18231365 (+)
BALB/cJ	MGP_BALBcJ_G0034405	protein coding gene	Chr9:17802597-17803755 (+)
C3H/HeJ	MGP_C3HHeJ_G0034117	protein coding gene	Chr9:18541205-18542363 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034926	protein coding gene	Chr9:18938865-18940023 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031856	protein coding gene	Chr9:17033396-17034554 (+)
CAST/EiJ	MGP_CASTEiJ_G0033440	protein coding gene	Chr9:18368334-18369492 (+)
CBA/J	MGP_CBAJ_G0034090	protein coding gene	Chr9:19649650-19650808 (+)
DBA/2J	MGP_DBA2J_G0034249	protein coding gene	Chr9:17890194-17891352 (+)
FVB/NJ	MGP_FVBNJ_G0034192	protein coding gene	Chr9:17398829-17399987 (+)
LP/J	MGP_LPJ_G0034334	protein coding gene	Chr9:18384120-18385278 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034235	protein coding gene	Chr9:21271807-21272965 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034946	protein coding gene	Chr9:18179976-18181134 (+)
PWK/PhJ	MGP_PWKPhJ_G0033146	protein coding gene	Chr9:17859683-17860902 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032980	protein coding gene	Chr9:18229757-18230915 (+)
WSB/EiJ	MGP_WSBEiJ_G0033555	protein coding gene	Chr9:17917395-17918553 (+)

Human Ortholog

ICAM4, intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ICAM4, intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
Synonyms

CD242, LW
Links

HGNC:5347

NCBI Gene ID: 3386

neXtProt AC: NX_Q14773

UniProt: Q14773
Chr Location

19p13.2; chr19:10286955-10288522 (+) GRCh38

MGI Vertebrate Homology

Icam4 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ICAM4
Gene Tree

Icam4

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
2 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Gene trapped

1
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

8 strains or lines available

Mice homozygous for a null allele exhibit decreased erythroblastic island formation.

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All GO Annotations

10
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

2
cDNA Data

21
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

38
RefSeq

4
UniProt

2
CCDS

CCDS22890.1, CCDS90509.1

Ensembl

ENSMUSG00000001014 (Evidence)
NCBI Gene

78369

			Length	Strain/Species	Flank
genomic	78369	NCBI Gene Model \| MGI Sequence Detail	1165	C57BL/6J	± kb
transcript	NM_001364509	RefSeq \| MGI Sequence Detail	1052	ZRU/MplStud
polypeptide	Q9ERM2	UniProt \| EBI \| MGI Sequence Detail	262	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001359 intercellular adhesion molecule 4

(term hierarchy)
InterPro Domains

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR013768 Intercellular adhesion molecule, N-terminal

IPR047012 Intercellular adhesion molecule/vascular cell adhesion molecule

IPR003987 Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal
GlyGen

Q9ERM2 3 sites

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All nucleic 24

cDNA 21

Primer pair 3

Microarray probesets 3

Summaries

All 32

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 2
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:338696 Maynard TM, et al., Transcriptional dysregulation in developing trigeminal sensory neurons in the LgDel mouse model of DiGeorge 22q11.2 deletion syndrome. Hum Mol Genet. 2020 Apr 15;29(6):1002-1017

TSS for Icam4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr83950	Chr9:20938811-20938822 (+)	-1,911 bp
Tssr83951	Chr9:20939118-20939132 (+)	-1,603 bp
Tssr83952	Chr9:20939217-20939234 (+)	-1,502 bp
Tssr83953	Chr9:20939246-20939260 (+)	-1,475 bp
Tssr83954	Chr9:20939274-20939287 (+)	-1,447 bp
Tssr83955	Chr9:20939363-20939381 (+)	-1,356 bp
Tssr83956	Chr9:20939439-20939451 (+)	-1,283 bp
Tssr83957	Chr9:20939511-20939524 (+)	-1,210 bp
Tssr83958	Chr9:20939553-20939581 (+)	-1,161 bp
Tssr83959	Chr9:20939753-20939772 (+)	-965 bp
Tssr83960	Chr9:20940721-20940738 (+)	2 bp
Tssr83961	Chr9:20940739-20940751 (+)	17 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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