Trim54 MGI Mouse Gene Detail - MGI:1889623 - tripartite motif-containing 54

Symbol

Trim54
Name

tripartite motif-containing 54
Synonyms

4930486E09Rik, 4930566I02Rik, MuRF3, Rnf30

Feature Type

protein coding gene
IDs

MGI:1889623
NCBI Gene: 58522
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr5:31274056-31294974 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 17.06 cM, cytoband B1
Mapping Data

2 experiments

SNPs within 2kb

618 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1889623	protein coding gene	Chr5:31273956-31294974 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029410	protein coding gene	Chr5:29097020-29123211 (+)
A/J	MGP_AJ_G0029376	protein coding gene	Chr5:28142824-28164008 (+)
AKR/J	MGP_AKRJ_G0029327	protein coding gene	Chr5:29299465-29321689 (+)
BALB/cJ	MGP_BALBcJ_G0029387	protein coding gene	Chr5:28660665-28681666 (+)
C3H/HeJ	MGP_C3HHeJ_G0029108	protein coding gene	Chr5:29307486-29328281 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029840	protein coding gene	Chr5:30904885-30927295 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027078	protein coding gene	Chr5:25609662-25630875 (+)
CAST/EiJ	MGP_CASTEiJ_G0028518	protein coding gene	Chr5:28392966-28413996 (+)
CBA/J	MGP_CBAJ_G0029076	protein coding gene	Chr5:31466596-31492026 (+)
DBA/2J	MGP_DBA2J_G0029225	protein coding gene	Chr5:28322983-28344027 (+)
FVB/NJ	MGP_FVBNJ_G0029183	protein coding gene	Chr5:27736771-27758026 (+)
LP/J	MGP_LPJ_G0029310	protein coding gene	Chr5:29551581-29576282 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029212	protein coding gene	Chr5:32336549-32359558 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029874	protein coding gene	Chr5:28807267-28829284 (+)
PWK/PhJ	MGP_PWKPhJ_G0028243	protein coding gene	Chr5:27444300-27466817 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028073	protein coding gene	Chr5:28183605-28205771 (+)
WSB/EiJ	MGP_WSBEiJ_G0028599	protein coding gene	Chr5:28867886-28891483 (+)

Human Ortholog

TRIM54, tripartite motif containing 54

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRIM54, tripartite motif containing 54
Synonyms

MURF, muRF3, MURF-3, RNF30
Links

HGNC:16008

NCBI Gene ID: 57159

neXtProt AC: NX_Q9BYV2

UniProt: Q9BYV2
Chr Location

2p23.3; chr2:27282429-27307439 (+) GRCh38

MGI Vertebrate Homology

Trim54 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TRIM54
Gene Tree

Trim54

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References

1 with disease annotations

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Phenotype Summary

12 phenotypes from 1 allele in 1 genetic background
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

2
Gene trapped

5
Radiation induced

2
Spontaneous

1
Targeted

2
Genomic Mutations

5 involving Trim54
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit normal cardiac function but are prone to cardiac rupture after acute myocardial infarction.

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All GO Annotations

12
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

761
Tissues

37
cDNA Data

8
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase trim54

ZFIN trim54

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All Sequences

37
RefSeq

2
UniProt

5
CCDS

CCDS19173.1

Ensembl

ENSMUSG00000062077 (Evidence)
NCBI Gene

58522

			Length	Strain/Species	Flank
genomic	ENSMUSG00000062077	Ensembl Gene Model \| MGI Sequence Detail	20919	C57BL/6J	± kb
transcript	ENSMUST00000013771	Ensembl \| MGI Sequence Detail	1434	Not Applicable
polypeptide	ENSMUSP00000013771	Ensembl \| MGI Sequence Detail	366	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000016661 tripartite motif-containing protein 54

(term hierarchy)
InterPro Domains

IPR000315 B-box-type zinc finger

IPR017903 COS domain

IPR042752 TRIM54, RING finger, HC subclass

IPR050143 Tripartite motif-containing

IPR033492 Tripartite motif-containing protein 54, B-box-type 2 zinc finger

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

IPR017907 Zinc finger, RING-type, conserved site

IPR027370 Zinc finger, RING-type, eukaryotic

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All nucleic 9

cDNA 9

Microarray probesets 3

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MGI:1922577, MGI:1925423

Summaries

All 62

Developmental Gene Expression 4

Diseases 1

Gene Ontology 6

Phenotypes 30
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:270838 Wiederstein JL, et al., Skeletal Muscle-Specific Methyltransferase METTL21C Trimethylates p97 and Regulates Autophagy-Associated Protein Breakdown. Cell Rep. 2018 May 1;23(5):1342-1356

TSS for Trim54:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr45678	Chr5:31273912-31273925 (+)	-137 bp
Tssr45679	Chr5:31273926-31273931 (+)	-127 bp
Tssr45680	Chr5:31273946-31273962 (+)	-102 bp
Tssr45681	Chr5:31274025-31274034 (+)	-26 bp
Tssr45682	Chr5:31274046-31274057 (+)	-4 bp
Tssr45683	Chr5:31274066-31274071 (+)	13 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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