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Plekha3 Gene Detail
Summary
  • Symbol
    Plekha3
  • Name
    pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 3
  • Synonyms
    FAPP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932515
    NCBI Gene: 83435
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:76505625-76527172 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 45.10 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    660 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1932515
protein coding gene Chr2:76505436-76527679 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025869
protein coding gene Chr2:77071056-77092634 (+)
A/J MGP_AJ_G0025846
protein coding gene Chr2:74082365-74103895 (+)
AKR/J MGP_AKRJ_G0025815
protein coding gene Chr2:76075488-76096790 (+)
BALB/cJ MGP_BALBcJ_G0025841
protein coding gene Chr2:74257142-74278678 (+)
C3H/HeJ MGP_C3HHeJ_G0025601
protein coding gene Chr2:76278274-76300275 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026288
protein coding gene Chr2:79357468-79378989 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023691
protein coding gene Chr2:71486212-71507881 (+)
CAST/EiJ MGP_CASTEiJ_G0025063
protein coding gene Chr2:76616544-76637954 (+)
CBA/J MGP_CBAJ_G0025582
protein coding gene Chr2:82293025-82314555 (+)
DBA/2J MGP_DBA2J_G0025713
protein coding gene Chr2:73670753-73692333 (+)
FVB/NJ MGP_FVBNJ_G0025675
protein coding gene Chr2:73067109-73089047 (+)
LP/J MGP_LPJ_G0025801
protein coding gene Chr2:76954017-76975584 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025706
protein coding gene Chr2:84114336-84135843 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026344
protein coding gene Chr2:76200177-76221698 (+)
PWK/PhJ MGP_PWKPhJ_G0024806
protein coding gene Chr2:73633856-73655643 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024612
protein coding gene Chr2:76448740-76470329 (+)
WSB/EiJ MGP_WSBEiJ_G0025132
protein coding gene Chr2:76668871-76689331 (+)



Homology
more
  • Human Ortholog
    PLEKHA3, pleckstrin homology domain containing A3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLEKHA3, pleckstrin homology domain containing A3
  • Synonyms
    FAPP1
  • Links
    NCBI Gene ID: 65977
    neXtProt AC: NX_Q9HB20
    UniProt: Q9HB20

  • Chr Location
    2q31.2; chr2:178480457-178516463 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000002733 Ensembl Gene Model | MGI Sequence Detail 21548 C57BL/6J ±  kb
transcript ENSMUST00000111920 Ensembl | MGI Sequence Detail 2534 Not Applicable  
polypeptide ENSMUSP00000107551 Ensembl | MGI Sequence Detail 297 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4

    Microarray probesets 4
References
more
  • Summaries
    All 36
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 13
  • Earliest
    J:65271 Dowler S, et al., Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. Biochem J. 2000 Oct 1;351(Pt 1):19-31
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
11/05/2024
MGI 6.24
The Jackson Laboratory