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Ranbp2 Gene Detail
Summary
  • Symbol
    Ranbp2
  • Name
    RAN binding protein 2
  • Synonyms
    A430087B05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:894323
    NCBI Gene: 19386
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:58282674-58329977 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 29.34 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    765 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894323
 protein coding gene Chr10:58282674-58330178 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017247
 protein coding gene Chr10:57549458-57601122 (+)
A/J MGP_AJ_G0017224
 protein coding gene Chr10:55885195-55934805 (+)
AKR/J MGP_AKRJ_G0017183
 protein coding gene Chr10:57341976-57389250 (+)
BALB/cJ MGP_BALBcJ_G0017185
 protein coding gene Chr10:55972758-56020746 (+)
C3H/HeJ MGP_C3HHeJ_G0017008
 protein coding gene Chr10:57259235-57308673 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017643
 protein coding gene Chr10:59646304-59697393 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015334
 protein coding gene Chr10:52995707-53045865 (+)
CAST/EiJ MGP_CASTEiJ_G0016579
 protein coding gene Chr10:57169504-57235407 (+)
CBA/J MGP_CBAJ_G0016980
 protein coding gene Chr10:61774138-61832769 (+)
DBA/2J MGP_DBA2J_G0017085
 protein coding gene Chr10:55212475-55264939 (+)
FVB/NJ MGP_FVBNJ_G0017079
 protein coding gene Chr10:54452411-54501117 (+)
LP/J MGP_LPJ_G0017160
 protein coding gene Chr10:57939381-57994233 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017107
 protein coding gene Chr10:64343849-64393055 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017680
 protein coding gene Chr10:57151691-57202926 (+)
PWK/PhJ MGP_PWKPhJ_G0016362
 protein coding gene Chr10:54991774-55042465 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016147
 protein coding gene Chr10:56520425-56570146 (+)
WSB/EiJ MGP_WSBEiJ_G0016643
 protein coding gene Chr10:57053029-57100548 (+)



Homology
more
  • Human Ortholog
    RANBP2, RAN binding protein 2
  • Vertebrate Orthologs
    10
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RANBP2, RAN binding protein 2
  • Synonyms
    ADANE, ANE1, IIAE3, NUP358, TRP1, TRP2
  • Links
    NCBI Gene ID: 5903
    neXtProt AC: NX_P49792
    UniProt: P49792

  • Chr Location
    2q13; chr2:108719482-109842301 (+)  GRCh38
  • Human Ortholog
    RGPD1, RANBP2 like and GRIP domain containing 1
  • Synonyms
    RanBP2L2, ranBP2L6, RGP1, RGPD2
  • Links
    NCBI Gene ID: 400966
    neXtProt AC: NX_P0DJD0
    UniProt: P0DJD0

  • Chr Location
    2p11.2; chr2:86913659-87013976 (+)  GRCh38
  • Human Ortholog
    RGPD2, RANBP2 like and GRIP domain containing 2
  • Synonyms
    NUP358, RANBP2L2, RGP2
  • Links
    NCBI Gene ID: 729857
    neXtProt AC: NX_P0DJD1
    UniProt: P0DJD1

  • Chr Location
    2p11.2; chr2:87755960-87989818 (-)  GRCh38
  • Human Ortholog
    RGPD3, RANBP2 like and GRIP domain containing 3
  • Synonyms
    RGP3
  • Links
    NCBI Gene ID: 653489
    neXtProt AC: NX_A6NKT7
    UniProt: A6NKT7

  • Chr Location
    2q12.2; chr2:106391290-106470935 (-)  GRCh38
  • Human Ortholog
    RGPD4, RANBP2 like and GRIP domain containing 4
  • Synonyms
    RGP4
  • Links
    NCBI Gene ID: 285190
    neXtProt AC: NX_Q7Z3J3
    UniProt: Q7Z3J3

  • Chr Location
    2q12.3; chr2:107826892-107892544 (+)  GRCh38
  • Human Ortholog
    RGPD5, RANBP2 like and GRIP domain containing 5
  • Synonyms
    BS-63, BS63, HEL161, RGP5
  • Links
    NCBI Gene ID: 84220
    neXtProt AC: NX_Q99666
    UniProt: Q99666

  • Chr Location
    2q13; chr2:109760618-109857705 (+)  GRCh38
  • Human Ortholog
    RGPD6, RANBP2 like and GRIP domain containing 6
  • Synonyms
    RanBP2L1, RanBP2L2, RGP6, RGPD7
  • Links
    NCBI Gene ID: 729540
    neXtProt AC: NX_Q99666
    UniProt: Q99666

  • Chr Location
    2q13; chr2:110513802-110611056 (-)  GRCh38
  • Human Ortholog
    RGPD8, RANBP2 like and GRIP domain containing 8
  • Synonyms
    RanBP2alpha, RANBP2L1, RGP8
  • Links
    NCBI Gene ID: 727851
    neXtProt AC: NX_O14715
    UniProt: O14715

  • Chr Location
    2q14.1
Human Diseases
more
  • Diseases
    2 with human RANBP2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 4 alleles in 5 genetic backgrounds
    1 images
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show abnormal morula morphology and complete embryonic lethality before implantation, with failure of blastocyst formation in in-vitro outgrowth assays. Mice homozygous for a gene trap allele are embryonic lethal, while heterozygotes display reduced ATP levels in the CNS, decreased glucose clearance, decreased susceptibility to diet-induced obesity, and reduced scotopic responses on some backgrounds .
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    55
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    995
  • Tissues
    97
  • cDNA Data
    17
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19386 NCBI Gene Model | MGI Sequence Detail 47304 C57BL/6J ±  kb
    transcript NM_011240 RefSeq | MGI Sequence Detail 9477 Not Specified  
    polypeptide Q9ERU9 UniProt | EBI | MGI Sequence Detail 3053 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • EC
      2.3.2.-
    • InterPro Domains
      IPR029000 Cyclophilin-like domain superfamily
      IPR020892 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
      IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
      IPR026054 Nuclear pore complex protein
      IPR022011 Nup358/RanBP2 E3 ligase domain
      IPR011993 PH-like domain superfamily
      IPR000156 Ran binding domain
      IPR045255 Ran binding protein RanBP1-like
      IPR011990 Tetratricopeptide-like helical domain superfamily
      IPR019734 Tetratricopeptide repeat
      IPR001876 Zinc finger, RanBP2-type
      IPR036443 Zinc finger, RanBP2-type superfamily
    • GlyGen
      Q9ERU9 17 sites, 4 N-linked glycans (4 sites), 1 O-linked glycan (13 sites)
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 17
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2143551, MGI:2443460
    References
    more
    • Summaries
      All 80
      Developmental Gene Expression 8
      Gene Ontology 15
      Phenotypes 33
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory