Foxj2 MGI Mouse Gene Detail - MGI:1926805

Symbol

Foxj2
Name

forkhead box J2
Synonyms

Fhx

Feature Type

protein coding gene
IDs

MGI:1926805
NCBI Gene: 60611
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr6:122797143-122822325 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 57.91 cM, cytoband F2
Mapping Data

2 experiments

SNPs within 2kb

719 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1926805	protein coding gene	Chr6:122796873-122822325 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031233	protein coding gene	Chr6:125936598-125966342 (+)
A/J	MGP_AJ_G0031202	protein coding gene	Chr6:121170070-121196010 (+)
AKR/J	MGP_AKRJ_G0031132	protein coding gene	Chr6:124519831-124547071 (+)
BALB/cJ	MGP_BALBcJ_G0031212	protein coding gene	Chr6:120879248-120907764 (+)
C3H/HeJ	MGP_C3HHeJ_G0030931	protein coding gene	Chr6:124489135-124518890 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031671	protein coding gene	Chr6:129264817-129293724 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028828	protein coding gene	Chr6:117769415-117796285 (+)
CAST/EiJ	MGP_CASTEiJ_G0030320	protein coding gene	Chr6:124749545-124777329 (+)
CBA/J	MGP_CBAJ_G0030894	protein coding gene	Chr6:134290404-134323995 (+)
DBA/2J	MGP_DBA2J_G0031050	protein coding gene	Chr6:120097347-120122720 (+)
FVB/NJ	MGP_FVBNJ_G0031003	protein coding gene	Chr6:119032749-119058066 (+)
LP/J	MGP_LPJ_G0031131	protein coding gene	Chr6:126130085-126159713 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031038	protein coding gene	Chr6:138259315-138284596 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031701	protein coding gene	Chr6:124411887-124438766 (+)
PWK/PhJ	MGP_PWKPhJ_G0030034	protein coding gene	Chr6:118935850-118965554 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029862	protein coding gene	Chr6:122557251-122584696 (+)
WSB/EiJ	MGP_WSBEiJ_G0030402	protein coding gene	Chr6:124725713-124757353 (+)

Human Ortholog

FOXJ2, forkhead box J2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FOXJ2, forkhead box J2
Synonyms

FHX
Links

HGNC:24818

NCBI Gene ID: 55810

neXtProt AC: NX_Q9P0K8

UniProt: Q9P0K8
Chr Location

12p13.31; chr12:8032716-8055517 (+) GRCh38

MGI Vertebrate Homology

Foxj2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FOXJ2
Gene Tree

Foxj2

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

1
Gene trapped

2
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit male infertility associated with male meiosis arrest and unrepaired double strand breaks in spermatocytes.

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All GO Annotations

29
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

969
Tissues

227
cDNA Data

59
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA FOXJ3

Xenbase foxj2

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All Sequences

37
RefSeq

2
UniProt

3
CCDS

CCDS20503.1

Ensembl

ENSMUSG00000003154 (Evidence)
NCBI Gene

60611

			Length	Strain/Species	Flank
genomic	60611	NCBI Gene Model \| MGI Sequence Detail	25183	C57BL/6J	± kb
transcript	NM_021899	RefSeq \| MGI Sequence Detail	5013	C57BL/6
polypeptide	Q9ES18	UniProt \| EBI \| MGI Sequence Detail	565	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000007629 forkhead box protein J2

(term hierarchy)
InterPro Domains

IPR045912 Forkhead box protein J2/3-like

IPR047393 Forkhead box protein J2, forkhead domain

IPR001766 Fork head domain

IPR030456 Fork head domain conserved site 2

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily

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All nucleic 63

cDNA 60

Primer pair 3

Microarray probesets 4

Summaries

All 41

Developmental Gene Expression 13

Gene Ontology 5

Phenotypes 5
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:343414 Bai FR, et al., Germline FOXJ2 overexpression causes male infertility via aberrant autophagy activation by LAMP2A upregulation. Cell Death Dis. 2022 Jul 30;13(7):665

TSS for Foxj2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr58702	Chr6:122796847-122796897 (+)	-271 bp
Tssr58703	Chr6:122796898-122796909 (+)	-239 bp
Tssr58704	Chr6:122797737-122797761 (+)	606 bp
Tssr58705	Chr6:122801594-122801606 (+)	4,457 bp
Tssr58706	Chr6:122803575-122803615 (+)	6,452 bp
Tssr58707	Chr6:122803625-122803640 (+)	6,490 bp
Tssr58708	Chr6:122803655-122803663 (+)	6,516 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/22/2024 MGI 6.24