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Rtn3 Gene Detail
Summary
  • Symbol
    Rtn3
  • Name
    reticulon 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339970
    NCBI Gene: 20168
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:7403266-7460646 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 5.32 cM, cytoband A
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1149 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1339970
 protein coding gene Chr19:7403260-7460656 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024792
 protein coding gene Chr19:4562534-4622684 (-)
A/J MGP_AJ_G0024759
 protein coding gene Chr19:4200765-4261479 (-)
AKR/J MGP_AKRJ_G0024732
 protein coding gene Chr19:4335832-4395728 (-)
BALB/cJ MGP_BALBcJ_G0024759
 protein coding gene Chr19:4315715-4375267 (-)
C3H/HeJ MGP_C3HHeJ_G0024526
 protein coding gene Chr19:4470724-4530729 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025205
 protein coding gene Chr19:4650906-4722772 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022639
 protein coding gene Chr19:4109089-4171398 (-)
CAST/EiJ MGP_CASTEiJ_G0023999
 protein coding gene Chr19:4377141-4444128 (-)
CBA/J MGP_CBAJ_G0024499
 protein coding gene Chr19:4726517-4783533 (-)
DBA/2J MGP_DBA2J_G0024626
 protein coding gene Chr19:4167249-4224753 (-)
FVB/NJ MGP_FVBNJ_G0024591
 protein coding gene Chr19:4209553-4268396 (-)
LP/J MGP_LPJ_G0024712
 protein coding gene Chr19:4410150-4475372 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024621
 protein coding gene Chr19:4625176-4688571 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025253
 protein coding gene Chr19:4491511-4563350 (-)
PWK/PhJ MGP_PWKPhJ_G0023745
 protein coding gene Chr19:4229268-4291017 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023549
 protein coding gene Chr19:4300827-4363403 (-)
WSB/EiJ MGP_WSBEiJ_G0024061
 protein coding gene Chr19:4396430-4458579 (-)



Homology
more
  • Human Ortholog
    RTN3, reticulon 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RTN3, reticulon 3
  • Synonyms
    ASYIP, HAP, NSPL2, NSPLII, RTN3-A1
  • Links
    NCBI Gene ID: 10313
    neXtProt AC: NX_O95197
    UniProt: O95197

  • Chr Location
    11q13.1; chr11:63681446-63759891 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Rtn3 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display age-related glomerulosclerosis and fibrosis with mitochondrial abnormalities and impaired renal function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    926
  • Tissues
    97
  • cDNA Data
    24
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024758 Ensembl Gene Model | MGI Sequence Detail 57381 C57BL/6J ±  kb
    transcript ENSMUST00000065304 Ensembl | MGI Sequence Detail 5013 Not Applicable  
    polypeptide ENSMUSP00000065810 Ensembl | MGI Sequence Detail 964 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 24
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2147752
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 10
      Phenotypes 15
    • Earliest
      J:55487 Moreira EF, et al., Cloning of a novel member of the reticulon gene family (RTN3): gene structure and chromosomal localization to 11q13. Genomics. 1999 May 15;58(1):73-81
    • Latest
      J:354577 Guo S, et al., Single-cell transcriptomic profiling reveals decreased ER protein Reticulon3 drives the progression of renal fibrosis. Mol Biomed. 2024 Jun 28;5(1):24
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory