Hrg MGI Mouse Gene Detail - MGI:2146636 - histidine-rich glycoprotein

Symbol

Hrg
Name

histidine-rich glycoprotein
Synonyms

D16JH2, D18020

Feature Type

protein coding gene
IDs

MGI:2146636
NCBI Gene: 94175
Alliance

gene page
Transcription Start Sites

18 TSS

Sequence Map

Chr16:22769822-22780406 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 13.79 cM
Mapping Data

2 experiments

SNPs within 2kb

401 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2146636	protein coding gene	Chr16:22769822-22780409 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022676	protein coding gene	Chr16:20482411-20492994 (+)
A/J	MGP_AJ_G0022637	protein coding gene	Chr16:19489554-19500165 (+)
AKR/J	MGP_AKRJ_G0022612	protein coding gene	Chr16:20304641-20315224 (+)
BALB/cJ	MGP_BALBcJ_G0022642	protein coding gene	Chr16:19689840-19700975 (+)
C3H/HeJ	MGP_C3HHeJ_G0022406	protein coding gene	Chr16:20414172-20424870 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023092	protein coding gene	Chr16:20924205-20941722 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020610	protein coding gene	Chr16:20175891-20187503 (+)
CAST/EiJ	MGP_CASTEiJ_G0021936	protein coding gene	Chr16:20407972-20420900 (+)
CBA/J	MGP_CBAJ_G0022378	protein coding gene	Chr16:21797631-21811297 (+)
DBA/2J	MGP_DBA2J_G0022510	protein coding gene	Chr16:19467252-19478800 (+)
FVB/NJ	MGP_FVBNJ_G0022486	protein coding gene	Chr16:19440430-19451750 (+)
LP/J	MGP_LPJ_G0022578	protein coding gene	Chr16:20243487-20255264 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022505	protein coding gene	Chr16:21334019-21344407 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023103	protein coding gene	Chr16:20249513-20260103 (+)
PWK/PhJ	MGP_PWKPhJ_G0021676	protein coding gene	Chr16:19710200-19721098 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021506	protein coding gene	Chr16:20038498-20048982 (+)
WSB/EiJ	MGP_WSBEiJ_G0021979	protein coding gene	Chr16:20217340-20227943 (+)

Human Ortholog

HRG, histidine rich glycoprotein

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HRG, histidine rich glycoprotein
Synonyms

HPRG, HRGP, THPH11
Links

HGNC:5181

NCBI Gene ID: 3273

neXtProt AC: NX_P04196

UniProt: P04196
Chr Location

3q27.3; chr3:186660216-186678234 (+) GRCh38

MGI Vertebrate Homology

Hrg stringent orthology
1 human;1 mouse;2 rat;1 zebrafish
HCOP

vertebrate homology predictions: HRG
Gene Tree

Hrg

Diseases

2 with human HRG associations

				Human Disease	Mouse Models
				thrombophilia due to HRG deficiency IDs thrombophilia due to HRG deficiency DOID:0111903 OMIM:613116 ORDO:217467 UMLS_CUI:C2751090
				thrombosis IDs thrombosis DOID:0060903 MESH:D013927

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

3
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display mild monocytosis, decreased bleeding time, faster clot lysis, and abnormal blood coagulation; however, wound healing is normal.

less

All GO Annotations

76
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

118
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hrg

less

All Sequences

40
RefSeq

2
UniProt

3
CCDS

CCDS49800.1

Ensembl

ENSMUSG00000022877 (Evidence)
NCBI Gene

94175

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022877	Ensembl Gene Model \| MGI Sequence Detail	10585	C57BL/6J	± kb
transcript	ENSMUST00000023590	Ensembl \| MGI Sequence Detail	1734	Not Applicable
polypeptide	ENSMUSP00000023590	Ensembl \| MGI Sequence Detail	536	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000008751 histidine-rich glycoprotein

(term hierarchy)
InterPro Domains

IPR000010 Cystatin domain

IPR046350 Cystatin superfamily

IPR050735 Kininogen/Fetuin/Histidine-rich Glycoprotein
GlyGen

Q9ESB3 6 sites, 4 N-linked glycans (4 sites), 1 O-linked glycan (1 site)

less

All nucleic 118

cDNA 118

Microarray probesets 2

less

MGI:2146400

Summaries

All 47

Developmental Gene Expression 1

Gene Ontology 12

Phenotypes 16
Earliest

J:71004 Hulett MD, et al., Murine histidine-rich glycoprotein: cloning, characterization and cellular origin. Immunol Cell Biol. 2000 Jun;78(3):280-7
Latest

J:346083 Foglia B, et al., Histidine-rich glycoprotein in metabolic dysfunction-associated steatohepatitis-related disease progression and liver carcinogenesis. Front Immunol. 2024;15:1342404

TSS for Hrg:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr137620	Chr16:22769829-22769840 (+)	13 bp
Tssr137621	Chr16:22769844-22769873 (+)	37 bp
Tssr137622	Chr16:22769878-22769890 (+)	62 bp
Tssr137623	Chr16:22769895-22769903 (+)	77 bp
Tssr137624	Chr16:22776219-22776232 (+)	6,404 bp
Tssr137625	Chr16:22776244-22776266 (+)	6,433 bp
Tssr137626	Chr16:22777911-22777922 (+)	8,095 bp
Tssr137627	Chr16:22777952-22777969 (+)	8,139 bp
Tssr137628	Chr16:22779523-22779536 (+)	9,708 bp
Tssr137629	Chr16:22779578-22779588 (+)	9,761 bp
Tssr137630	Chr16:22779634-22779641 (+)	9,816 bp
Tssr137631	Chr16:22779671-22779682 (+)	9,855 bp
Tssr137632	Chr16:22779691-22779705 (+)	9,876 bp
Tssr137633	Chr16:22779716-22779720 (+)	9,896 bp
Tssr137634	Chr16:22779794-22779822 (+)	9,986 bp
Tssr137635	Chr16:22779879-22779894 (+)	10,065 bp
Tssr137636	Chr16:22779989-22779997 (+)	10,171 bp
Tssr137637	Chr16:22780044-22780051 (+)	10,226 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24