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Prss8 Gene Detail
Summary
  • Symbol
    Prss8
  • Name
    serine protease 8 (prostasin)
  • Synonyms
    2410039E18Rik, CAP1, fr, mCAP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923810
    NCBI Gene: 76560
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:127524889-127529266 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.84 cM
  • Mapping Data
    17 experiments
Strain
Comparison
more
  • SNPs within 2kb
    189 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923810
 protein coding gene Chr7:127524888-127529276 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033065
 protein coding gene Chr7:132315249-132319637 (-)
A/J MGP_AJ_G0033048
 protein coding gene Chr7:128771235-128775623 (-)
AKR/J MGP_AKRJ_G0032980
 protein coding gene Chr7:132105191-132109578 (-)
BALB/cJ MGP_BALBcJ_G0033049
 protein coding gene Chr7:128427404-128431791 (-)
C3H/HeJ MGP_C3HHeJ_G0032763
 protein coding gene Chr7:132006936-132011323 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033558
 protein coding gene Chr7:137463628-137468016 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030531
 protein coding gene Chr7:129959102-129963379 (-)
CAST/EiJ MGP_CASTEiJ_G0032092
 protein coding gene Chr7:123800232-123804650 (-)
CBA/J MGP_CBAJ_G0032736
 protein coding gene Chr7:142134053-142138441 (-)
DBA/2J MGP_DBA2J_G0032888
 protein coding gene Chr7:126747015-126751403 (-)
FVB/NJ MGP_FVBNJ_G0032841
 protein coding gene Chr7:126609184-126613572 (-)
LP/J MGP_LPJ_G0032982
 protein coding gene Chr7:133782295-133786683 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032873
 protein coding gene Chr7:143199332-143203720 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033578
 protein coding gene Chr7:131089541-131095629 (-)
PWK/PhJ MGP_PWKPhJ_G0031799
 protein coding gene Chr7:119755374-119759772 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031645
 protein coding gene Chr7:117900244-117904676 (-)
WSB/EiJ MGP_WSBEiJ_G0032204
 protein coding gene Chr7:132054715-132059103 (-)



Homology
more
  • Human Ortholog
    PRSS8, serine protease 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRSS8, serine protease 8
  • Synonyms
    CAP1, PROSTASIN
  • Links
    NCBI Gene ID: 5652
    neXtProt AC: NX_Q16651
    UniProt: Q16651

  • Chr Location
    16p11.2; chr16:31131433-31135727 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Prss8 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    48 phenotypes from 9 alleles in 8 genetic backgrounds
    27 phenotypes from multigenic genotypes
    2 images
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mutations result in impaired skin barrier function, dehydration, and postnatal lethality. A mutation preventing activation of the enzyme causes abnormal whisker and hair development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    979
  • Tissues
    132
  • cDNA Data
    10
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 76560 NCBI Gene Model | MGI Sequence Detail 4378 C57BL/6J ±  kb
    transcript NM_133351 RefSeq | MGI Sequence Detail 1841 C57BL/6  
    polypeptide Q9ESD1 UniProt | EBI | MGI Sequence Detail 342 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 10
      Primer pair 2
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-9870, MGI:2141897, MGI:2142334, MGI:95577
    References
    more
    • Summaries
      All 94
      Developmental Gene Expression 16
      Diseases 2
      Gene Ontology 9
      Phenotypes 37
    • Earliest
      J:92 Falconer DS, et al., Two new hair mutants, rough and frizzy in the house mouse. J Hered. 1952;43(1):53-57
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory