Zdhhc16 MGI Mouse Gene Detail - MGI:1921418 - zinc finger, DHHC domain containing 16

Symbol

Zdhhc16
Name

zinc finger, DHHC domain containing 16
Synonyms

1500015N03Rik, Abl-philin 2, Ablphilin 2, APH2

Feature Type

protein coding gene
IDs

MGI:1921418
NCBI Gene: 74168
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr19:41921919-41932543 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 35.48 cM, cytoband D1
Mapping Data

2 experiments

SNPs within 2kb

325 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921418	protein coding gene	Chr19:41921884-41932543 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025132	protein coding gene	Chr19:41236789-41248035 (+)
A/J	MGP_AJ_G0025109	protein coding gene	Chr19:39254556-39265019 (+)
AKR/J	MGP_AKRJ_G0025077	protein coding gene	Chr19:40544135-40555865 (+)
BALB/cJ	MGP_BALBcJ_G0025103	protein coding gene	Chr19:39313447-39324162 (+)
C3H/HeJ	MGP_C3HHeJ_G0024863	protein coding gene	Chr19:40694150-40704840 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025546	protein coding gene	Chr19:42311637-42322125 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022960	protein coding gene	Chr19:38608645-38618615 (+)
CAST/EiJ	MGP_CASTEiJ_G0024328	protein coding gene	Chr19:40365113-40382549 (+)
CBA/J	MGP_CBAJ_G0024843	protein coding gene	Chr19:44373831-44387547 (+)
DBA/2J	MGP_DBA2J_G0024975	protein coding gene	Chr19:39105028-39115670 (+)
FVB/NJ	MGP_FVBNJ_G0024936	protein coding gene	Chr19:38879694-38890097 (+)
LP/J	MGP_LPJ_G0025061	protein coding gene	Chr19:41230844-41241263 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024967	protein coding gene	Chr19:44000836-44012773 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025604	protein coding gene	Chr19:40581780-40593384 (+)
PWK/PhJ	MGP_PWKPhJ_G0024077	protein coding gene	Chr19:38979879-38992172 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023881	protein coding gene	Chr19:39326209-39336447 (+)
WSB/EiJ	MGP_WSBEiJ_G0024398	protein coding gene	Chr19:40735646-40746159 (+)

Human Ortholog

ZDHHC16, zinc finger DHHC-type palmitoyltransferase 16

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZDHHC16, zinc finger DHHC-type palmitoyltransferase 16
Synonyms

APH2, DHHC-16
Links

HGNC:20714

NCBI Gene ID: 84287

neXtProt AC: NX_Q969W1

UniProt: Q969W1
Chr Location

10q24.1; chr10:97446170-97457370 (+) GRCh38

MGI Vertebrate Homology

Zdhhc16 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ZDHHC16
Gene Tree

Zdhhc16

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Phenotype Summary

23 phenotypes from 2 alleles in 2 genetic backgrounds
3 phenotypes from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

2
Gene trapped

4
Targeted

6
Incidental Mutations

APF
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display prenatal and neonatal lethality with bradycardia, abnormal heart morphology and eye defects.

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All GO Annotations

18
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

732
Tissues

26
cDNA Data

8
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase zdhhc16

ZFIN zdhhc16a, zdhhc16b

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All Sequences

104
RefSeq

22
UniProt

7
CCDS

CCDS29817.1

Ensembl

ENSMUSG00000025157 (Evidence)
NCBI Gene

74168

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025157	Ensembl Gene Model \| MGI Sequence Detail	10625	C57BL/6J	± kb
transcript	ENSMUST00000026154	Ensembl \| MGI Sequence Detail	1821	Not Applicable
polypeptide	ENSMUSP00000026154	Ensembl \| MGI Sequence Detail	361	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000029890 palmitoyltransferase ZDHHC16

(term hierarchy)
EC

2.3.1.225
InterPro Domains

IPR001594 Palmitoyltransferase, DHHC domain

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All nucleic 10

cDNA 9

Primer pair 1

Microarray probesets 2

Summaries

All 41

Developmental Gene Expression 5

Gene Ontology 9

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Zdhhc16:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156448	Chr19:41921266-41921283 (+)	-644 bp
Tssr156449	Chr19:41921903-41921979 (+)	22 bp
Tssr156450	Chr19:41922347-41922351 (+)	430 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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