Pgpep1 MGI Mouse Gene Detail - MGI:1913772

Symbol

Pgpep1
Name

pyroglutamyl-peptidase I
Synonyms

2810003H13Rik, Pcp, PGP-I

Feature Type

protein coding gene
IDs

MGI:1913772
NCBI Gene: 66522
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr8:71099085-71113038 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 34.15 cM, cytoband C1
Mapping Data

2 experiments

SNPs within 2kb

327 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913772	protein coding gene	Chr8:71099085-71113096 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033717	protein coding gene	Chr8:70926738-70942069 (-)
A/J	MGP_AJ_G0033700	protein coding gene	Chr8:68046307-68059813 (-)
AKR/J	MGP_AKRJ_G0033625	protein coding gene	Chr8:69981410-69997744 (-)
BALB/cJ	MGP_BALBcJ_G0033696	protein coding gene	Chr8:68284405-68297792 (-)
C3H/HeJ	MGP_C3HHeJ_G0033406	protein coding gene	Chr8:70631207-70644717 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0034213	protein coding gene	Chr8:73605617-73618905 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031157	protein coding gene	Chr8:62865387-62879190 (-)
CAST/EiJ	MGP_CASTEiJ_G0032731	protein coding gene	Chr8:70120008-70133058 (-)
CBA/J	MGP_CBAJ_G0033384	protein coding gene	Chr8:76251948-76268312 (-)
DBA/2J	MGP_DBA2J_G0033538	protein coding gene	Chr8:67760868-67776916 (-)
FVB/NJ	MGP_FVBNJ_G0033479	protein coding gene	Chr8:66889650-66903806 (-)
LP/J	MGP_LPJ_G0033625	protein coding gene	Chr8:70955238-70969819 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033522	protein coding gene	Chr8:78909030-78923665 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034231	protein coding gene	Chr8:70169266-70182783 (-)
PWK/PhJ	MGP_PWKPhJ_G0032439	protein coding gene	Chr8:67063916-67077387 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0032275	protein coding gene	Chr8:69133271-69146633 (-)
WSB/EiJ	MGP_WSBEiJ_G0032846	protein coding gene	Chr8:70529823-70545563 (-)

Human Ortholog

PGPEP1, pyroglutamyl-peptidase I

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PGPEP1, pyroglutamyl-peptidase I
Synonyms

PAP-I, Pcp, PGI, PGP, PGP-I, PGPI
Links

HGNC:13568

NCBI Gene ID: 54858

neXtProt AC: NX_Q9NXJ5

UniProt: Q9NXJ5
Chr Location

19p13.11; chr19:18340598-18369950 (+) GRCh38

MGI Vertebrate Homology

Pgpep1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PGPEP1
Protein SuperFamily

Prld-crbxl_pptds
Gene Tree

Pgpep1

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

17
Targeted

2
Genomic Mutations

1 involving Pgpep1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

7
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

860
Tissues

17
cDNA Data

12
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pgpep1

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All Sequences

68
RefSeq

14
UniProt

6
CCDS

CCDS22377.1

Ensembl

ENSMUSG00000056204 (Evidence)
NCBI Gene

66522

			Length	Strain/Species	Flank
genomic	ENSMUSG00000056204	Ensembl Gene Model \| MGI Sequence Detail	13954	C57BL/6J	± kb
transcript	ENSMUST00000070173	Ensembl \| MGI Sequence Detail	4883	Not Applicable
polypeptide	ENSMUSP00000070778	Ensembl \| MGI Sequence Detail	209	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000012620 pyroglutamyl-peptidase 1

(term hierarchy)
EC

3.4.19.3
InterPro Domains

IPR000816 Peptidase C15, pyroglutamyl peptidase I

IPR016125 Peptidase C15, pyroglutamyl peptidase I-like

IPR036440 Peptidase C15, pyroglutamyl peptidase I-like superfamily

IPR033694 Pyroglutamyl peptidase I, Cys active site

IPR033693 Pyroglutamyl peptidase I, Glu active site

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All nucleic 12

cDNA 12

Microarray probesets 4

Summaries

All 33

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Pgpep1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr81646	Chr8:71112473-71112489 (-)	557 bp
Tssr81645	Chr8:71112295-71112346 (-)	717 bp
Tssr81644	Chr8:71103069-71103081 (-)	9,963 bp
Tssr81643	Chr8:71101023-71101027 (-)	12,013 bp
Tssr81642	Chr8:71099776-71099783 (-)	13,258 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/22/2024 MGI 6.24