Tnfrsf13b MGI Mouse Gene Detail - MGI:1889411 - tumor necrosis factor receptor superfamily, member 13b

Symbol

Tnfrsf13b
Name

tumor necrosis factor receptor superfamily, member 13b
Synonyms

1200009E08Rik, Taci

Feature Type

protein coding gene
IDs

MGI:1889411
NCBI Gene: 57916
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:61017581-61040198 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 37.96 cM
Mapping Data

2 experiments

SNPs within 2kb

736 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1889411	protein coding gene	Chr11:61017567-61040435 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018432	protein coding gene	Chr11:61070707-61097078 (+)
A/J	MGP_AJ_G0018401	protein coding gene	Chr11:58818602-58841212 (+)
AKR/J	MGP_AKRJ_G0018371	protein coding gene	Chr11:60658924-60681504 (+)
BALB/cJ	MGP_BALBcJ_G0018372	protein coding gene	Chr11:59121200-59143923 (+)
C3H/HeJ	MGP_C3HHeJ_G0018185	protein coding gene	Chr11:60631496-60657874 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018824	protein coding gene	Chr11:63008679-63033295 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016470	protein coding gene	Chr11:55956968-55978782 (+)
CAST/EiJ	MGP_CASTEiJ_G0017742	protein coding gene	Chr11:60738073-60762916 (+)
CBA/J	MGP_CBAJ_G0018159	protein coding gene	Chr11:65748929-65773176 (+)
DBA/2J	MGP_DBA2J_G0018268	protein coding gene	Chr11:58400318-58422730 (+)
FVB/NJ	MGP_FVBNJ_G0018259	protein coding gene	Chr11:58078295-58098930 (+)
LP/J	MGP_LPJ_G0018341	protein coding gene	Chr11:61648089-61674217 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018283	protein coding gene	Chr11:66776831-66800295 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018865	protein coding gene	Chr11:60785304-60809855 (+)
PWK/PhJ	MGP_PWKPhJ_G0017515	protein coding gene	Chr11:58996126-59020065 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017305	protein coding gene	Chr11:60598454-60623337 (+)
WSB/EiJ	MGP_WSBEiJ_G0017794	protein coding gene	Chr11:60395974-60421618 (+)

Human Ortholog

TNFRSF13B, TNF receptor superfamily member 13B

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TNFRSF13B, TNF receptor superfamily member 13B
Synonyms

CD267, CVID, CVID2, IGAD2, RYZN, TACI, TNFRSF14B
Links

HGNC:18153

NCBI Gene ID: 23495

neXtProt AC: NX_O14836

UniProt: O14836
Chr Location

17p11.2; chr17:16929816-16972118 (-) GRCh38

MGI Vertebrate Homology

Tnfrsf13b stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: TNFRSF13B
Gene Tree

Tnfrsf13b

Diseases

1 with Tnfrsf13b mouse models; 1 with human TNFRSF13B associations

Human Disease

Mouse Models

systemic lupus erythematosus

IDs

View 1 model

common variable immunodeficiency 2

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

3 with disease annotations

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Phenotype Summary

38 phenotypes from 3 alleles in 4 genetic backgrounds
1 phenotype from multigenic genotypes
52 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

3
Targeted

6
Genomic Mutations

3 involving Tnfrsf13b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Nullizygous mice show increased B cell numbers and splenomegaly. Homozygotes for a null allele show impaired T cell-independent immune responses and isotype switching. Homozygotes for another null allele develop lymphoproliferation and fatal autoimmune nephritis with high titers of autoantibodies.

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All GO Annotations

10
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

739
Tissues

22
cDNA Data

40
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

53
RefSeq

5
UniProt

6
CCDS

CCDS24806.1

Ensembl

ENSMUSG00000010142 (Evidence)
NCBI Gene

57916

			Length	Strain/Species	Flank
genomic	ENSMUSG00000010142	Ensembl Gene Model \| MGI Sequence Detail	22618	C57BL/6J	± kb
transcript	ENSMUST00000101103	Ensembl \| MGI Sequence Detail	750	Not Applicable
polypeptide	ENSMUSP00000098662	Ensembl \| MGI Sequence Detail	249	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000001956 tumor necrosis factor receptor superfamily member 13B

(term hierarchy)
InterPro Domains

IPR015384 TACI, cysteine-rich domain

IPR001368 TNFR/NGFR cysteine-rich region

IPR022317 Tumour necrosis factor receptor 13B

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All nucleic 43

cDNA 41

Primer pair 2

Microarray probesets 3

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MGI:1918966

Summaries

All 97

Developmental Gene Expression 3

Diseases 3

Gene Ontology 6

Phenotypes 52
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Tnfrsf13b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101942	Chr11:61017573-61017588 (+)	0 bp
Tssr101943	Chr11:61033283-61033297 (+)	15,709 bp
Tssr101944	Chr11:61033303-61033333 (+)	15,737 bp
Tssr101945	Chr11:61033514-61033522 (+)	15,937 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24