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Cldn12 Gene Detail
Summary
  • Symbol
    Cldn12
  • Name
    claudin 12
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929288
    NCBI Gene: 64945
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:5555109-5564953 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 2.98 cM, cytoband A1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    385 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929288
 protein coding gene Chr5:5539537-5564958 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029272
 protein coding gene Chr5:2399141-2425947 (-)
A/J MGP_AJ_G0029235
 protein coding gene Chr5:2293650-2320672 (-)
AKR/J MGP_AKRJ_G0029185
 protein coding gene Chr5:2339200-2367105 (-)
BALB/cJ MGP_BALBcJ_G0029253
 protein coding gene Chr5:2499862-2526576 (-)
C3H/HeJ MGP_C3HHeJ_G0028973
 protein coding gene Chr5:2533016-2563760 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029703
 protein coding gene Chr5:2776206-2809328 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026946
 protein coding gene Chr5:2379200-2402964 (-)
CAST/EiJ MGP_CASTEiJ_G0028386
 protein coding gene Chr5:2493309-2522802 (-)
CBA/J MGP_CBAJ_G0028934
 protein coding gene Chr5:2749416-2782904 (-)
DBA/2J MGP_DBA2J_G0029087
 protein coding gene Chr5:2442593-2468759 (-)
FVB/NJ MGP_FVBNJ_G0029048
 protein coding gene Chr5:2298410-2323824 (-)
LP/J MGP_LPJ_G0029176
 protein coding gene Chr5:2486657-2518624 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029075
 protein coding gene Chr5:2666512-2697048 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029734
 protein coding gene Chr5:2393747-2425683 (-)
PWK/PhJ MGP_PWKPhJ_G0028108
 protein coding gene Chr5:2372373-2398932 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027941
 protein coding gene Chr5:2693310-2722663 (-)
WSB/EiJ MGP_WSBEiJ_G0028466
 protein coding gene Chr5:2421680-2455368 (-)



Homology
more
  • Human Ortholog
    CLDN12, claudin 12
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLDN12, claudin 12
  • Links
    NCBI Gene ID: 9069
    neXtProt AC: NX_P56749
    UniProt: P56749

  • Chr Location
    7q21.13; chr7:90383721-90513402 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    41 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a knock-out allele show no signs of blood-brain barrier tight junction dysfunction under healthy or neuroinflammatory conditions. However, subtle and mostly sex specific alterations associated with CNS, energy metabolism, and cardiovascular functions are observed.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    777
  • Tissues
    52
  • cDNA Data
    63
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 64945 NCBI Gene Model | MGI Sequence Detail 9845 C57BL/6J ±  kb
    transcript NM_001193660 RefSeq | MGI Sequence Detail 3718 C57BL/6  
    polypeptide Q9ET43 UniProt | EBI | MGI Sequence Detail 244 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 66
      cDNA 63
      Primer pair 3

      Microarray probesets 4
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 13
      Gene Ontology 7
      Phenotypes 16
    • Earliest
      J:72106 Niimi T, et al., claudin-18, a Novel Downstream Target Gene for the T/EBP/NKX2.1 Homeodomain Transcription Factor, Encodes Lung- and Stomach-Specific Isoforms through Alternative Splicing. Mol Cell Biol. 2001 Nov;21(21):7380-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory