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Rangrf Gene Detail
Summary
  • Symbol
    Rangrf
  • Name
    RAN guanine nucleotide release factor
  • Synonyms
    2400006H24Rik, Mog1, Rangnrf
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889073
    NCBI Gene: 57785
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:68863310-68866011 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 42.24 cM, cytoband B3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    118 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889073
 protein coding gene Chr11:68863310-68866011 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018511
 protein coding gene Chr11:69363835-69366959 (-)
A/J MGP_AJ_G0018480
 protein coding gene Chr11:66762193-66764894 (-)
AKR/J MGP_AKRJ_G0018449
 protein coding gene Chr11:68757488-68760736 (-)
BALB/cJ MGP_BALBcJ_G0018451
 protein coding gene Chr11:67080191-67083868 (-)
C3H/HeJ MGP_C3HHeJ_G0018264
 protein coding gene Chr11:68777643-68781643 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018903
 protein coding gene Chr11:71474880-71477718 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016547
 protein coding gene Chr11:63699368-63702091 (-)
CAST/EiJ MGP_CASTEiJ_G0017820
 protein coding gene Chr11:69014433-69015855 (-)
CBA/J MGP_CBAJ_G0018238
 protein coding gene Chr11:74665349-74668050 (-)
DBA/2J MGP_DBA2J_G0018347
 protein coding gene Chr11:66359285-66361385 (-)
FVB/NJ MGP_FVBNJ_G0018337
 protein coding gene Chr11:65979109-65982219 (-)
LP/J MGP_LPJ_G0018418
 protein coding gene Chr11:69945903-69950031 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018360
 protein coding gene Chr11:75319344-75323340 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018944
 protein coding gene Chr11:69003620-69006355 (-)
PWK/PhJ MGP_PWKPhJ_G0017595
 protein coding gene Chr11:66989718-66992760 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017383
 protein coding gene Chr11:68824047-68826757 (-)
WSB/EiJ MGP_WSBEiJ_G0017873
 protein coding gene Chr11:68646853-68649753 (-)



Homology
more
  • Human Ortholog
    RANGRF, RAN guanine nucleotide release factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RANGRF, RAN guanine nucleotide release factor
  • Synonyms
    HSPC165, HSPC236, MOG1, RANGNRF
  • Links
    NCBI Gene ID: 29098
    neXtProt AC: NX_Q9HD47
    UniProt: Q9HD47

  • Chr Location
    17p13.1; chr17:8288654-8290092 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with a knock-out allele exhibit prolonged QRS duration, left ventricle dysfunction and increased risk of isoproterenol-induced arrhythmias and sudden death. Hearts show abnormal sarcomeres and mitochondria, with increased level of ATP supply.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    6
  • cDNA Data
    9
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 57785 NCBI Gene Model | MGI Sequence Detail 2702 C57BL/6J ±  kb
    transcript NM_021329 RefSeq | MGI Sequence Detail 845 C57BL/6  
    polypeptide Q9JIB0 UniProt | EBI | MGI Sequence Detail 185 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1913665
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 7
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:325055 Zhao M, et al., Mog1 deficiency promotes cardiac contractile dysfunction and isoproterenol-induced arrhythmias associated with cardiac fibrosis and Cx43 remodeling. Biochim Biophys Acta Mol Basis Dis. 2022 May 6;1868(9):166429
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory