Sh2b2 MGI Mouse Gene Detail - MGI:1345171

Symbol

Sh2b2
Name

SH2B adaptor protein 2
Synonyms

Aps

Feature Type

protein coding gene
IDs

MGI:1345171
NCBI Gene: 23921
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr5:136247001-136275410 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 75.93 cM, cytoband G1
Mapping Data

2 experiments

SNPs within 2kb

769 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1345171	protein coding gene	Chr5:136247001-136275446 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0030205	protein coding gene	Chr5:140855867-140890983 (-)
A/J	MGP_AJ_G0030173	protein coding gene	Chr5:134779392-134808816 (-)
AKR/J	MGP_AKRJ_G0030106	protein coding gene	Chr5:139130585-139162947 (-)
BALB/cJ	MGP_BALBcJ_G0030183	protein coding gene	Chr5:136135988-136168710 (-)
C3H/HeJ	MGP_C3HHeJ_G0029899	protein coding gene	Chr5:139757548-139786933 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030636	protein coding gene	Chr5:146086318-146116296 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027856	protein coding gene	Chr5:129058593-129089278 (-)
CAST/EiJ	MGP_CASTEiJ_G0029309	protein coding gene	Chr5:139156666-139187195 (-)
CBA/J	MGP_CBAJ_G0029869	protein coding gene	Chr5:151789818-151831185 (-)
DBA/2J	MGP_DBA2J_G0030020	protein coding gene	Chr5:134679721-134708401 (-)
FVB/NJ	MGP_FVBNJ_G0029975	protein coding gene	Chr5:133831512-133864018 (-)
LP/J	MGP_LPJ_G0030109	protein coding gene	Chr5:141272060-141305866 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030007	protein coding gene	Chr5:154760184-154795471 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030676	protein coding gene	Chr5:138955352-138987083 (-)
PWK/PhJ	MGP_PWKPhJ_G0029022	protein coding gene	Chr5:133742873-133776169 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028858	protein coding gene	Chr5:136514927-136545715 (-)
WSB/EiJ	MGP_WSBEiJ_G0029382	protein coding gene	Chr5:139689985-139722478 (-)

Human Ortholog

SH2B2, SH2B adaptor protein 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SH2B2, SH2B adaptor protein 2
Synonyms

APS
Links

HGNC:17381

NCBI Gene ID: 10603

neXtProt AC: NX_O14492

UniProt: O14492
Chr Location

7q22.1; chr7:102285091-102321711 (+) GRCh38

MGI Vertebrate Homology

Sh2b2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SH2B2
Gene Tree

Sh2b2

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

1
Gene trapped

1
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Inactivation of this gene results in increased insulin sensitivity accompanied by hypoinsulinemia.

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All GO Annotations

48
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

707
Tissues

1
cDNA Data

22
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sh2b2

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All Sequences

57
RefSeq

16
UniProt

3
CCDS

CCDS39327.1, CCDS80431.1

Ensembl

ENSMUSG00000005057 (Evidence)
NCBI Gene

23921

			Length	Strain/Species	Flank
genomic	ENSMUSG00000005057	Ensembl Gene Model \| MGI Sequence Detail	28410	C57BL/6J	± kb
transcript	ENSMUST00000196397	Ensembl \| MGI Sequence Detail	2797	Not Applicable
polypeptide	ENSMUSP00000142398	Ensembl \| MGI Sequence Detail	621	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000014810 SH2B adapter protein 2

(term hierarchy)
PDB

1V5M
InterPro Domains

IPR015012 Phenylalanine zipper

IPR036290 Phenylalanine zipper superfamily

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR035058 SH2B2, SH2 domain

IPR030523 SH2B adapter protein

IPR000980 SH2 domain

IPR036860 SH2 domain superfamily

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All nucleic 23

cDNA 22

Primer pair 1

Microarray probesets 3

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MGI:1859755

Summaries

All 39

Developmental Gene Expression 1

Gene Ontology 12

Phenotypes 10
Earliest

J:54187 Moodie SA, et al., Identification of the APS protein as a novel insulin receptor substrate. J Biol Chem. 1999 Apr 16;274(16):11186-93
Latest

J:211139 Sheng L, et al., Hepatic SH2B1 and SH2B2 regulate liver lipid metabolism and VLDL secretion in mice. PLoS One. 2013;8(12):e83269

TSS for Sh2b2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr53826	Chr5:136275433-136275452 (-)	-33 bp
Tssr53825	Chr5:136275413-136275424 (-)	-9 bp
Tssr53824	Chr5:136275407-136275412 (-)	0 bp
Tssr53823	Chr5:136275372-136275396 (-)	26 bp
Tssr53822	Chr5:136274837-136274840 (-)	571 bp
Tssr53821	Chr5:136274150-136274158 (-)	1,256 bp
Tssr53820	Chr5:136274104-136274117 (-)	1,299 bp
Tssr53819	Chr5:136273785-136273803 (-)	1,616 bp
Tssr53818	Chr5:136273719-136273762 (-)	1,669 bp
Tssr53817	Chr5:136273702-136273713 (-)	1,702 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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