Polm MGI Mouse Gene Detail - MGI:1860191 - polymerase (DNA directed), mu

Symbol

Polm
Name

polymerase (DNA directed), mu
Synonyms

B230309I03Rik, Tdt-N

Feature Type

protein coding gene
IDs

MGI:1860191
NCBI Gene: 54125
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:5777860-5788016 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 3.87 cM
Mapping Data

2 experiments

SNPs within 2kb

384 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1860191	protein coding gene	Chr11:5777860-5788831 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018008	protein coding gene	Chr11:2910774-2920927 (-)
A/J	MGP_AJ_G0017981	protein coding gene	Chr11:2795271-2805420 (-)
AKR/J	MGP_AKRJ_G0017945	protein coding gene	Chr11:2947398-2957547 (-)
BALB/cJ	MGP_BALBcJ_G0017949	protein coding gene	Chr11:2786085-2796215 (-)
C3H/HeJ	MGP_C3HHeJ_G0017762	protein coding gene	Chr11:2816512-2826545 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018401	protein coding gene	Chr11:2988792-2998944 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016059	protein coding gene	Chr11:2695086-2705996 (-)
CAST/EiJ	MGP_CASTEiJ_G0017324	protein coding gene	Chr11:2784144-2794177 (-)
CBA/J	MGP_CBAJ_G0017737	protein coding gene	Chr11:3345382-3360804 (-)
DBA/2J	MGP_DBA2J_G0017847	protein coding gene	Chr11:2703078-2713517 (-)
FVB/NJ	MGP_FVBNJ_G0017839	protein coding gene	Chr11:2731210-2741346 (-)
LP/J	MGP_LPJ_G0017918	protein coding gene	Chr11:2989750-2999717 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017865	protein coding gene	Chr11:2958605-2968765 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018441	protein coding gene	Chr11:2947972-2958108 (-)
PWK/PhJ	MGP_PWKPhJ_G0017104	protein coding gene	Chr11:2726161-2736786 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016901	protein coding gene	Chr11:2914394-2924891 (-)
WSB/EiJ	MGP_WSBEiJ_G0017378	protein coding gene	Chr11:2788663-2798819 (-)

Human Ortholog

POLM, DNA polymerase mu

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

POLM, DNA polymerase mu
Synonyms

Pol Mu, Tdt-N
Links

HGNC:9185

NCBI Gene ID: 27434

neXtProt AC: NX_Q9NP87

UniProt: Q9NP87
Chr Location

7p13; chr7:44072062-44082530 (-) GRCh38

MGI Vertebrate Homology

Polm stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: POLM
Protein SuperFamily

DNA_NT
Gene Tree

Polm

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Phenotype Summary

9 phenotypes from 4 alleles in 5 genetic backgrounds
5 phenotypes from multigenic genotypes
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (ENU)

2
Endonuclease-mediated

3
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene display an apparently normal phenotype. However, B cell maturation and proliferation is abnormal.

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All GO Annotations

12
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

3
cDNA Data

42
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase polm

ZFIN polm

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All Sequences

57
RefSeq

12
UniProt

3
CCDS

CCDS24405.1

Ensembl

ENSMUSG00000020474 (Evidence)
NCBI Gene

54125

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020474	Ensembl Gene Model \| MGI Sequence Detail	10157	C57BL/6J	± kb
transcript	ENSMUST00000109837	Ensembl \| MGI Sequence Detail	2697	Not Applicable
polypeptide	ENSMUSP00000105463	Ensembl \| MGI Sequence Detail	511	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000012979 DNA-directed DNA/RNA polymerase mu

(term hierarchy)
PDB

2IHM, 6GO3, 6GO4, 6GO5, 6GO6, 6GO7
EC

2.7.7.7
InterPro Domains

IPR001357 BRCT domain

IPR036420 BRCT domain superfamily

IPR002054 DNA-directed DNA polymerase X

IPR027249 DNA-directed DNA/RNA polymerase mu

IPR001726 DNA nucleotidylexotransferase (TdT) / DNA-directed DNA/RNA polymerase mu

IPR010996 DNA polymerase beta-like, N-terminal domain

IPR028207 DNA polymerase beta, palm domain

IPR029398 DNA polymerase beta, thumb domain

IPR022312 DNA polymerase family X

IPR019843 DNA polymerase family X, binding site

IPR018944 DNA polymerase lambda, fingers domain

IPR027421 DNA polymerase lambda lyase domain superfamily

IPR037160 DNA polymerase, thumb domain superfamily

IPR043519 Nucleotidyltransferase superfamily

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All nucleic 43

cDNA 42

Primer pair 1

Microarray probesets 3

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MGI:2144181, MGI:2443119

Summaries

All 50

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 22
Earliest

J:61446 Dominguez O, et al., DNA polymerase mu (Pol mu), homologous to TdT, could act as a DNA mutator in eukaryotic cells. EMBO J. 2000 Apr 3;19(7):1731-42
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Polm:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr106649	Chr11:5787760-5787835 (-)	218 bp
Tssr106648	Chr11:5787745-5787758 (-)	264 bp
Tssr106647	Chr11:5787727-5787736 (-)	284 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24