Zc3h8 MGI Mouse Gene Detail - MGI:1930128 - zinc finger CCCH type containing 8

Symbol

Zc3h8
Name

zinc finger CCCH type containing 8
Synonyms

E130108N08Rik, Fliz1

Feature Type

protein coding gene
IDs

MGI:1930128
NCBI Gene: 57432
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr2:128768188-128785997 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 62.63 cM
Mapping Data

2 experiments

SNPs within 2kb

612 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1930128	protein coding gene	Chr2:128768188-128786018 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026478	protein coding gene	Chr2:132294021-132318018 (-)
A/J	MGP_AJ_G0026442	protein coding gene	Chr2:126933154-126950924 (-)
AKR/J	MGP_AKRJ_G0026417	protein coding gene	Chr2:130530301-130548128 (-)
BALB/cJ	MGP_BALBcJ_G0026454	protein coding gene	Chr2:127195064-127213085 (-)
C3H/HeJ	MGP_C3HHeJ_G0026197	protein coding gene	Chr2:131045339-131065067 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026899	protein coding gene	Chr2:136429228-136449908 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024276	protein coding gene	Chr2:121758662-121776931 (-)
CAST/EiJ	MGP_CASTEiJ_G0025658	protein coding gene	Chr2:131297959-131316556 (-)
CBA/J	MGP_CBAJ_G0026177	protein coding gene	Chr2:141475353-141496637 (-)
DBA/2J	MGP_DBA2J_G0026311	protein coding gene	Chr2:126320151-126337932 (-)
FVB/NJ	MGP_FVBNJ_G0026275	protein coding gene	Chr2:124970321-124987947 (-)
LP/J	MGP_LPJ_G0026416	protein coding gene	Chr2:132520419-132540067 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026295	protein coding gene	Chr2:145393464-145414022 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026954	protein coding gene	Chr2:130575339-130593628 (-)
PWK/PhJ	MGP_PWKPhJ_G0025394	protein coding gene	Chr2:125897105-125915180 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025196	protein coding gene	Chr2:129679790-129697553 (-)
WSB/EiJ	MGP_WSBEiJ_G0025732	protein coding gene	Chr2:131483293-131503598 (-)

Human Ortholog

ZC3H8, zinc finger CCCH-type containing 8

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZC3H8, zinc finger CCCH-type containing 8
Synonyms

Fliz1, ZC3HDC8
Links

HGNC:30941

NCBI Gene ID: 84524

neXtProt AC: NX_Q8N5P1

UniProt: Q8N5P1
Chr Location

2q14.1; chr2:112211529-112255136 (-) GRCh38

MGI Vertebrate Homology

Zc3h8 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ZC3H8
Gene Tree

Zc3h8

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Phenotype Summary

17 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

1
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Zc3h8
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

35
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

781
Tissues

70
cDNA Data

24
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

39
RefSeq

4
UniProt

3
CCDS

CCDS16718.1

Ensembl

ENSMUSG00000027387 (Evidence)
NCBI Gene

57432

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027387	Ensembl Gene Model \| MGI Sequence Detail	17810	C57BL/6J	± kb
transcript	ENSMUST00000028866	Ensembl \| MGI Sequence Detail	1624	Not Applicable
polypeptide	ENSMUSP00000028866	Ensembl \| MGI Sequence Detail	305	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000029884 zinc finger CCCH domain-containing protein 8

(term hierarchy)
InterPro Domains

IPR045124 Protein suppressor of sable-like

IPR000571 Zinc finger, CCCH-type

IPR036855 Zinc finger, CCCH-type superfamily

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All nucleic 27

cDNA 24

Primer pair 2

Other 1

Microarray probesets 3

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MGI:1925697, MGI:2139187

Summaries

All 41

Developmental Gene Expression 5

Gene Ontology 6

Phenotypes 10
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Zc3h8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr26178	Chr2:128785905-128785954 (-)	67 bp
Tssr26177	Chr2:128785880-128785896 (-)	109 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/22/2024 MGI 6.24