Ccdc86 MGI Mouse Gene Detail - MGI:1277220 - coiled-coil domain containing 86

Symbol

Ccdc86
Name

coiled-coil domain containing 86
Synonyms

4933411H20Rik, 6720480F16Rik, cyclon, D19Ertd678e

Feature Type

protein coding gene
IDs

MGI:1277220
NCBI Gene: 108673
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr19:10918845-10926630 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 7.41 cM, cytoband B
Mapping Data

4 experiments

SNPs within 2kb

327 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1277220	protein coding gene	Chr19:10918845-10926630 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024864	protein coding gene	Chr19:8323902-8331627 (-)
A/J	MGP_AJ_G0024832	protein coding gene	Chr19:7761413-7769139 (-)
AKR/J	MGP_AKRJ_G0024807	protein coding gene	Chr19:8061280-8070456 (-)
BALB/cJ	MGP_BALBcJ_G0024832	protein coding gene	Chr19:7803835-7811560 (-)
C3H/HeJ	MGP_C3HHeJ_G0024598	protein coding gene	Chr19:7951834-7959499 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025280	protein coding gene	Chr19:8677699-8685484 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022707	protein coding gene	Chr19:8176155-8183500 (-)
CAST/EiJ	MGP_CASTEiJ_G0024071	protein coding gene	Chr19:7608435-7616113 (-)
CBA/J	MGP_CBAJ_G0024572	protein coding gene	Chr19:8743825-8753366 (-)
DBA/2J	MGP_DBA2J_G0024699	protein coding gene	Chr19:7764046-7771784 (-)
FVB/NJ	MGP_FVBNJ_G0024666	protein coding gene	Chr19:7810667-7819715 (-)
LP/J	MGP_LPJ_G0024786	protein coding gene	Chr19:8277548-8285273 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024693	protein coding gene	Chr19:8630783-8638508 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025328	protein coding gene	Chr19:8082460-8090254 (-)
PWK/PhJ	MGP_PWKPhJ_G0023816	protein coding gene	Chr19:7218401-7226071 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023621	protein coding gene	Chr19:7270811-7278431 (-)
WSB/EiJ	MGP_WSBEiJ_G0024133	protein coding gene	Chr19:7977624-7985349 (-)

Human Ortholog

CCDC86, coiled-coil domain containing 86

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CCDC86, coiled-coil domain containing 86
Synonyms

Cgr1
Links

HGNC:28359

NCBI Gene ID: 79080

neXtProt AC: NX_Q9H6F5

UniProt: Q9H6F5
Chr Location

11q12.2; chr11:60842113-60851081 (+) GRCh38

MGI Vertebrate Homology

Ccdc86 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CCDC86
Gene Tree

Ccdc86

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
7 phenotypes from multigenic genotypes
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

2
Gene trapped

2
Targeted

4
Transgenic

1
Find Mice (IMSR)

16 strains or lines available

Homozygous null mice are embryonic lethal. CD4 T cells in heterozygote mice are resistant to activation induced cell death.

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All GO Annotations

9
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

754
Tissues

47
cDNA Data

67
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ccdc86

ZFIN ccdc86

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All Sequences

44
RefSeq

2
UniProt

1
CCDS

CCDS29593.1

Ensembl

ENSMUSG00000024732 (Evidence)
NCBI Gene

108673

			Length	Strain/Species	Flank
genomic	108673	NCBI Gene Model \| MGI Sequence Detail	7786	C57BL/6J	± kb
transcript	NM_023731	RefSeq \| MGI Sequence Detail	3003	ZRU/MplStud
polypeptide	Q9JJ89	UniProt \| EBI \| MGI Sequence Detail	426	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000029340 coiled-coil domain-containing protein 86

(term hierarchy)
InterPro Domains

IPR005579 Cgr1-like

IPR026570 Coiled-coil domain-containing protein 86

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All nucleic 69

cDNA 68

Primer pair 1

Microarray probesets 6

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MGI:1915338, MGI:1921329

Summaries

All 38

Developmental Gene Expression 3

Gene Ontology 4

Phenotypes 7
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Ccdc86:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr158262	Chr19:10926602-10926641 (-)	8 bp
Tssr158261	Chr19:10925932-10925938 (-)	695 bp
Tssr158260	Chr19:10925914-10925931 (-)	707 bp
Tssr158259	Chr19:10925866-10925908 (-)	743 bp
Tssr158258	Chr19:10925661-10925706 (-)	946 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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