Riox1 MGI Mouse Gene Detail - MGI:1919202

Symbol

Riox1
Name

ribosomal oxygenase 1
Synonyms

2410016O06Rik, NO66

Feature Type

protein coding gene
IDs

MGI:1919202
NCBI Gene: 71952
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr12:83997382-83999725 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 38.97 cM, cytoband D3
Mapping Data

3 experiments

SNPs within 2kb

150 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919202	protein coding gene	Chr12:83997382-83999727 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019919	protein coding gene	Chr12:84617178-84619523 (+)
A/J	MGP_AJ_G0019876	protein coding gene	Chr12:81411065-81413410 (+)
AKR/J	MGP_AKRJ_G0019852	protein coding gene	Chr12:83617645-83619991 (+)
BALB/cJ	MGP_BALBcJ_G0019856	protein coding gene	Chr12:81755051-81757396 (+)
C3H/HeJ	MGP_C3HHeJ_G0019662	protein coding gene	Chr12:84077149-84079494 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020308	protein coding gene	Chr12:87036025-87038370 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017925	protein coding gene	Chr12:78334625-78336975 (+)
CAST/EiJ	MGP_CASTEiJ_G0019211	protein coding gene	Chr12:79018461-79020806 (+)
CBA/J	MGP_CBAJ_G0019633	protein coding gene	Chr12:90372441-90374786 (+)
DBA/2J	MGP_DBA2J_G0019748	protein coding gene	Chr12:80953876-80956221 (+)
FVB/NJ	MGP_FVBNJ_G0019734	protein coding gene	Chr12:79901137-79903482 (+)
LP/J	MGP_LPJ_G0019820	protein coding gene	Chr12:84491146-84493491 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019773	protein coding gene	Chr12:93352384-93354729 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020342	protein coding gene	Chr12:83205979-83208324 (+)
PWK/PhJ	MGP_PWKPhJ_G0018975	protein coding gene	Chr12:75435244-75437589 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018770	protein coding gene	Chr12:77693492-77695837 (+)
WSB/EiJ	MGP_WSBEiJ_G0019263	protein coding gene	Chr12:83890998-83893343 (+)

Human Ortholog

RIOX1, ribosomal oxygenase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RIOX1, ribosomal oxygenase 1
Synonyms

C14orf169, hsNO66, JMJD9, MAPJD, NO66, ROX, URLC2
Links

HGNC:20968

NCBI Gene ID: 79697

neXtProt AC: NX_Q9H6W3

UniProt: Q9H6W3
Chr Location

14q24.3; chr14:73490933-73493394 (+) GRCh38

MGI Vertebrate Homology

Riox1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RIOX1
Gene Tree

Riox1

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Phenotype Summary

18 phenotypes from 1 allele in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

4
Genomic Mutations

1 involving Riox1
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele activated in mesenchyme exhibit increased body length and weight, increased ossification with increased bone mass, bone mineral density, and volume, increased osteoblasts; and decrease osteoclasts.

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All GO Annotations

27
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

714
Tissues

8
cDNA Data

42
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase riox1

ZFIN riox1

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All Sequences

36
RefSeq

2
UniProt

1
CCDS

CCDS26033.1

Ensembl

ENSMUSG00000046791 (Evidence)
NCBI Gene

71952

			Length	Strain/Species	Flank
genomic	ENSMUSG00000046791	Ensembl Gene Model \| MGI Sequence Detail	2344	C57BL/6J	± kb
transcript	ENSMUST00000053744	Ensembl \| MGI Sequence Detail	2344	Not Applicable
polypeptide	ENSMUSP00000057984	Ensembl \| MGI Sequence Detail	603	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000011299 ribosomal oxygenase 1

(term hierarchy)
EC

1.14.11.27, 1.14.11.79
InterPro Domains

IPR039994 Histone lysine demethylase/ribosomal histidine hydroxylase NO66-like

IPR003347 JmjC domain

IPR049043 RIOX1/NO66-like, C-terminal winged helix domain

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All nucleic 43

cDNA 42

Other 1

Microarray probesets 3

Summaries

All 39

Developmental Gene Expression 3

Gene Ontology 9

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:326061 Xiao Y, et al., RIOX1-demethylated cGAS regulates ionizing radiation-elicited DNA repair. Bone Res. 2022 Feb 24;10(1):19

TSS for Riox1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114295	Chr12:83996793-83996806 (+)	-582 bp
Tssr114296	Chr12:83996828-83996845 (+)	-545 bp
Tssr114297	Chr12:83996857-83996864 (+)	-521 bp
Tssr114298	Chr12:83997408-83997479 (+)	62 bp
Tssr114299	Chr12:83997587-83997618 (+)	221 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24