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Trpm5 Gene Detail
Summary
  • Symbol
    Trpm5
  • Name
    transient receptor potential cation channel, subfamily M, member 5
  • Synonyms
    9430099A16Rik, Ltrpc5, Mtr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861718
    NCBI Gene: 56843
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:142625266-142648379 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 88.11 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    512 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861718
 protein coding gene Chr7:142622890-142648379 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033269
 protein coding gene Chr7:148350029-148375518 (-)
A/J MGP_AJ_G0033252
 protein coding gene Chr7:144051268-144076757 (-)
AKR/J MGP_AKRJ_G0033183
 protein coding gene Chr7:148101617-148127106 (-)
BALB/cJ MGP_BALBcJ_G0033252
 protein coding gene Chr7:143827480-143852953 (-)
C3H/HeJ MGP_C3HHeJ_G0032968
 protein coding gene Chr7:147864275-147889764 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033762
 protein coding gene Chr7:153713814-153739303 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030735
 protein coding gene Chr7:145264538-145290407 (-)
CAST/EiJ MGP_CASTEiJ_G0032290
 protein coding gene Chr7:140167648-140193109 (-)
CBA/J MGP_CBAJ_G0032939
 protein coding gene Chr7:158973475-158998964 (-)
DBA/2J MGP_DBA2J_G0033093
 protein coding gene Chr7:142025583-142051072 (-)
FVB/NJ MGP_FVBNJ_G0033041
 protein coding gene Chr7:141946205-141971694 (-)
LP/J MGP_LPJ_G0033185
 protein coding gene Chr7:149868867-149894356 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033075
 protein coding gene Chr7:159568793-159594282 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033782
 protein coding gene Chr7:147064942-147091870 (-)
PWK/PhJ MGP_PWKPhJ_G0031999
 protein coding gene Chr7:135328234-135353811 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031845
 protein coding gene Chr7:133870830-133896313 (-)
WSB/EiJ MGP_WSBEiJ_G0032402
 protein coding gene Chr7:148065484-148090975 (-)



Homology
more
  • Human Ortholog
    TRPM5, transient receptor potential cation channel subfamily M member 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRPM5, transient receptor potential cation channel subfamily M member 5
  • Synonyms
    LTRPC5, MTR1
  • Links
    NCBI Gene ID: 29850
    neXtProt AC: NX_Q9NZQ8
    UniProt: Q9NZQ8

  • Chr Location
    11p15.5; chr11:2403991-2444514 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    68 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice demonstrate abnormal taste perception, responding to sour and salty stimuli but not to sweet, or bitter stimuli.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    957
  • Tissues
    151
  • cDNA Data
    17
  • Literature Summary
    22
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56843 NCBI Gene Model | MGI Sequence Detail 23114 C57BL/6J ±  kb
    transcript NM_020277 RefSeq | MGI Sequence Detail 4383 C57BL/6  
    polypeptide Q9JJH7 UniProt | EBI | MGI Sequence Detail 1158 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 2
      cDNA 19
      Primer pair 8

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2443185
    References
    more
    • Summaries
      All 133
      Developmental Gene Expression 22
      Gene Ontology 10
      Phenotypes 68
    • Earliest
      J:63552 Yatsuki H, et al., Sequence-based structural features between Kvlqt1 and Tapa1 on mouse chromosome 7F4/F5 corresponding to the Beckwith-Wiedemann syndrome region on human 11p15.5: long-stretches of unusually well conserved intronic sequences of kvlqt1 between mouse and human. DNA Res. 2000 Jun 30;7(3):195-206
    • Latest
      J:350715 Ascencio Gutierrez V, et al., TRPM4 and PLCbeta3 contribute to normal behavioral responses to an array of sweeteners and carbohydrates but PLCbeta3 is not needed for taste-driven licking for glucose. Chem Senses. 2024 Jan 1;49
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/19/2024
    MGI 6.24     		The Jackson Laboratory