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Slco1b2 Gene Detail
Summary
  • Symbol
    Slco1b2
  • Name
    solute carrier organic anion transporter family, member 1b2
  • Synonyms
    7330442B20Rik, mlst-1, Oatp1b2, Slc21a10, Slc21a6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351899
    NCBI Gene: 28253
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:141575244-141632372 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 72.57 cM, cytoband G1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1903 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351899
 protein coding gene Chr6:141575178-141632372 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031453
 protein coding gene Chr6:146380757-146447885 (+)
A/J MGP_AJ_G0031428
 protein coding gene Chr6:140603025-140662887 (+)
AKR/J MGP_AKRJ_G0031356
 protein coding gene Chr6:144814257-144874657 (+)
BALB/cJ MGP_BALBcJ_G0031435
 protein coding gene Chr6:140429190-140488931 (+)
C3H/HeJ MGP_C3HHeJ_G0031157
 protein coding gene Chr6:144881236-144939908 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031897
 protein coding gene Chr6:150383712-150446107 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0030525
 protein coding gene Chr6:144422519-144486595 (+)
CBA/J MGP_CBAJ_G0031117
 protein coding gene Chr6:156122188-156183138 (+)
DBA/2J MGP_DBA2J_G0031274
 protein coding gene Chr6:139440102-139498864 (+)
FVB/NJ MGP_FVBNJ_G0031225
 protein coding gene Chr6:138227244-138295273 (+)
LP/J MGP_LPJ_G0031358
 protein coding gene Chr6:146524029-146588309 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031265
 protein coding gene Chr6:159997893-160074310 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031929
 protein coding gene Chr6:144647470-144705023 (+)
PWK/PhJ MGP_PWKPhJ_G0030252
 protein coding gene Chr6:137941545-138000460 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030076
 protein coding gene Chr6:142871612-142933777 (+)
WSB/EiJ MGP_WSBEiJ_G0030618
 protein coding gene Chr6:145287610-145350754 (+)



Homology
more
  • Human Ortholog
    SLCO1B1, solute carrier organic anion transporter family member 1B1
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLCO1B1, solute carrier organic anion transporter family member 1B1
  • Synonyms
    HBLRR, LST-1, LST1, OATP1B1, OATP2, OATP-C, OATPC, SLC21A6
  • Links
    NCBI Gene ID: 10599
    neXtProt AC: NX_Q9Y6L6
    UniProt: Q9Y6L6

  • Chr Location
    12p12.1; chr12:21131194-21239796 (+)  GRCh38
  • Human Ortholog
    SLCO1B3, solute carrier organic anion transporter family member 1B3
  • Synonyms
    HBLRR, LST-2, LST3, LST-3TM13, OATP1B3, OATP-8, OATP8, SLC21A8
  • Links
    NCBI Gene ID: 28234
    neXtProt AC: NX_Q9NPD5
    UniProt: Q9NPD5

  • Chr Location
    12p12.2; chr12:20810702-20916911 (+)  GRCh38
  • Human Ortholog
    SLCO1B7, solute carrier organic anion transporter family member 1B7 (putative)
  • Synonyms
    LST-3, LST3, LST-3TM12, OATP1B7, SLC21A21
  • Links
    NCBI Gene ID: 338821
    neXtProt AC: NX_G3V0H7
    UniProt: G3V0H7

  • Chr Location
    12p12.2; chr12:20962768-21090106 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human SLCO1B1,SLCO1B3 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 3 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display slight abnormalities in blood chemistry and are resistant to injury induced by some classes of hepatotoxins.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    732
  • Tissues
    24
  • cDNA Data
    25
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030236 Ensembl Gene Model | MGI Sequence Detail 57129 C57BL/6J ±  kb
    transcript ENSMUST00000042812 Ensembl | MGI Sequence Detail 3307 Not Applicable  
    polypeptide ENSMUSP00000044326 Ensembl | MGI Sequence Detail 689 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 25
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1351894, MGI:1925925
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 18
    • Earliest
      J:62737 Ogura K, et al., Full-length cDNA cloning and genomic organization of the mouse liver-specific organic anion transporter-1 (lst-1). Biochem Biophys Res Commun. 2000 Jun 7;272(2):563-70
    • Latest
      J:334921 Truong JK, et al., Active enterohepatic cycling is not required for the choleretic actions of 24-norUrsodeoxycholic acid in mice. JCI Insight. 2023 Mar 22;8(6)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory