Crybb3 MGI Mouse Gene Detail - MGI:102717

Symbol

Crybb3
Name

crystallin, beta B3

Feature Type

protein coding gene
IDs

MGI:102717
NCBI Gene: 12962
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr5:113223705-113229450 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 55.38 cM
Mapping Data

4 experiments

SNPs within 2kb

264 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_102717	protein coding gene	Chr5:113223705-113230102 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029913	protein coding gene	Chr5:115706485-115712224 (-)
A/J	MGP_AJ_G0029879	protein coding gene	Chr5:111197965-111203694 (-)
AKR/J	MGP_AKRJ_G0029817	protein coding gene	Chr5:114725945-114731682 (-)
BALB/cJ	MGP_BALBcJ_G0029890	protein coding gene	Chr5:112559628-112565367 (-)
C3H/HeJ	MGP_C3HHeJ_G0029610	protein coding gene	Chr5:115159122-115164860 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030343	protein coding gene	Chr5:120206531-120212276 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027572	protein coding gene	Chr5:106013024-106018998 (-)
CAST/EiJ	MGP_CASTEiJ_G0029018	protein coding gene	Chr5:114084536-114090288 (-)
CBA/J	MGP_CBAJ_G0029577	protein coding gene	Chr5:124750791-124756529 (-)
DBA/2J	MGP_DBA2J_G0029727	protein coding gene	Chr5:111265667-111271404 (-)
FVB/NJ	MGP_FVBNJ_G0029684	protein coding gene	Chr5:110003990-110009729 (-)
LP/J	MGP_LPJ_G0029815	protein coding gene	Chr5:116271059-116276798 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029715	protein coding gene	Chr5:129273137-129278874 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030384	protein coding gene	Chr5:114160771-114166500 (-)
PWK/PhJ	MGP_PWKPhJ_G0028732	protein coding gene	Chr5:109880447-109886220 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028570	protein coding gene	Chr5:111670254-111676025 (-)
WSB/EiJ	MGP_WSBEiJ_G0029094	protein coding gene	Chr5:114687030-114692768 (-)

Human Ortholog

CRYBB3, crystallin beta B3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CRYBB3, crystallin beta B3
Synonyms

CATCN2, CRYB3, CTRCT22
Links

HGNC:2400

NCBI Gene ID: 1417

neXtProt AC: NX_P26998

UniProt: P26998
Chr Location

22q11.23; chr22:25199858-25207359 (+) GRCh38

MGI Vertebrate Homology

Crybb3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CRYBB3
Gene Tree

Crybb3

Diseases

1 with human CRYBB3 associations

				Human Disease	Mouse Models
				cataract 22 multiple types IDs cataract 22 multiple types DOID:0110268 ICD10CM:Q12.0 OMIM:609741

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Crybb3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

6
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

746
Tissues

13
cDNA Data

10
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase crybb3

ZFIN crybb3

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All Sequences

76
RefSeq

19
UniProt

5
CCDS

CCDS19547.1

Ensembl

ENSMUSG00000029352 (Evidence)
NCBI Gene

12962

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029352	Ensembl Gene Model \| MGI Sequence Detail	5746	C57BL/6J	± kb
transcript	ENSMUST00000076069	Ensembl \| MGI Sequence Detail	816	Not Applicable
polypeptide	ENSMUSP00000075440	Ensembl \| MGI Sequence Detail	211	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000005913 beta-crystallin B3

(term hierarchy)
InterPro Domains

IPR001064 Beta/gamma crystallin

IPR050252 Beta/Gamma-Crystallin

IPR011024 Gamma-crystallin-like

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All nucleic 13

cDNA 10

Primer pair 2

Other 1

Microarray probesets 3

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MGD-MRK-19621, MGI:2140996

Summaries

All 48

Developmental Gene Expression 10

Gene Ontology 4

Phenotypes 13
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Crybb3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr52606	Chr5:113229446-113229450 (-)	2 bp
Tssr52605	Chr5:113228432-113228444 (-)	1,012 bp
Tssr52604	Chr5:113226316-113226329 (-)	3,127 bp
Tssr52603	Chr5:113225096-113225105 (-)	4,349 bp
Tssr52602	Chr5:113225069-113225089 (-)	4,371 bp
Tssr52601	Chr5:113225036-113225048 (-)	4,408 bp
Tssr52600	Chr5:113225016-113225030 (-)	4,427 bp
Tssr52599	Chr5:113224988-113224997 (-)	4,457 bp
Tssr52598	Chr5:113224852-113224871 (-)	4,588 bp
Tssr52597	Chr5:113224405-113224409 (-)	5,043 bp
Tssr52596	Chr5:113223737-113223762 (-)	5,700 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24