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Nectin1 Gene Detail
Summary
  • Symbol
    Nectin1
  • Name
    nectin cell adhesion molecule 1
  • Synonyms
    Cd111, HIgR, HveC, nectin-1, PRR, PRR1, Pvrl1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926483
    NCBI Gene: 58235
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:43655251-43718758 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 24.42 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1285 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926483
 protein coding gene Chr9:43655251-43743955 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034686
 protein coding gene Chr9:42168714-42232306 (+)
A/J MGP_AJ_G0034666
 protein coding gene Chr9:41023567-41086267 (+)
AKR/J MGP_AKRJ_G0034592
 protein coding gene Chr9:41841052-41903748 (+)
BALB/cJ MGP_BALBcJ_G0034657
 protein coding gene Chr9:40754576-40817676 (+)
C3H/HeJ MGP_C3HHeJ_G0034368
 protein coding gene Chr9:42321893-42388660 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035180
 protein coding gene Chr9:43439226-43507024 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032093
 protein coding gene Chr9:40623012-40685420 (+)
CAST/EiJ MGP_CASTEiJ_G0033691
 protein coding gene Chr9:42142943-42207472 (+)
CBA/J MGP_CBAJ_G0034341
 protein coding gene Chr9:44983902-45054620 (+)
DBA/2J MGP_DBA2J_G0034500
 protein coding gene Chr9:40934910-40998378 (+)
FVB/NJ MGP_FVBNJ_G0034440
 protein coding gene Chr9:40179778-40243889 (+)
LP/J MGP_LPJ_G0034581
 protein coding gene Chr9:42471182-42536810 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034484
 protein coding gene Chr9:46895431-46961949 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035199
 protein coding gene Chr9:41747607-41813087 (+)
PWK/PhJ MGP_PWKPhJ_G0033396
 protein coding gene Chr9:40792024-40855162 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033232
 protein coding gene Chr9:42035479-42098532 (+)
WSB/EiJ MGP_WSBEiJ_G0033804
 protein coding gene Chr9:41795390-41862855 (+)



Homology
more
  • Human Ortholog
    NECTIN1, nectin cell adhesion molecule 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NECTIN1, nectin cell adhesion molecule 1
  • Synonyms
    CD111, CLPED1, ED4, HIgR, HV1S, HVEC, nectin-1, OFC7, PRR, PRR1, PVRL1, PVRR, PVRR1, SK-12
  • Links
    NCBI Gene ID: 5818
    neXtProt AC: NX_Q15223
    UniProt: Q15223

  • Chr Location
    11q23.3; chr11:119623408-119729200 (-)  GRCh38
Human Diseases
more
  • Diseases
    4 with human NECTIN1 associations

Human Disease Mouse Models
      
IDs
IDs
 View 3 "NOT" models
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 2 alleles in 3 genetic backgrounds
    10 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit eye abnormalities including microphthalmia, absent vitreous body, abnormal ciliary body, retinal layers, and lenses, and open eyelids at birth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    762
  • Tissues
    36
  • cDNA Data
    52
  • Literature Summary
    36
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 58235 NCBI Gene Model | MGI Sequence Detail 63508 C57BL/6J ±  kb
    transcript NM_021424 RefSeq | MGI Sequence Detail 5701 C57BL/6  
    polypeptide Q9JKF6 UniProt | EBI | MGI Sequence Detail 515 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 58
      Genomic 2
      cDNA 52
      Primer pair 3
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2143125, MGI:2143319
    References
    more
    • Summaries
      All 94
      Developmental Gene Expression 36
      Diseases 1
      Gene Ontology 13
      Phenotypes 24
    • Earliest
      J:61531 Satoh-Horikawa K, et al., Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell-cell adhesion activities. J Biol Chem. 2000 Apr 7;275(14):10291-9
    • Latest
      J:355676 Tomioka Y, et al., Single amino acid mutation of nectin-1 provides remarkable resistance against lethal pseudorabies virus infection in mice. J Vet Med Sci. 2024 Jan 26;86(1):120-127
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory