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Prokr1 Gene Detail
Summary
  • Symbol
    Prokr1
  • Name
    prokineticin receptor 1
  • Synonyms
    EG-VEGFR1, Gpr73, Pkr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929676
    NCBI Gene: 58182
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr6:87555573-87567725 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 38.28 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    405 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929676
 protein coding gene Chr6:87555568-87567741 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030994
 protein coding gene Chr6:88931682-88945634 (-)
A/J MGP_AJ_G0030960
 protein coding gene Chr6:85496562-85508820 (-)
AKR/J MGP_AKRJ_G0030891
 protein coding gene Chr6:87971818-87985196 (-)
BALB/cJ MGP_BALBcJ_G0030973
 protein coding gene Chr6:85496880-85509031 (-)
C3H/HeJ MGP_C3HHeJ_G0030737
 protein coding gene Chr6:96487218-96499353 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031430
 protein coding gene Chr6:91314997-91327160 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028614
 protein coding gene Chr6:83676996-83688932 (-)
CAST/EiJ MGP_CASTEiJ_G0030082
 protein coding gene Chr6:88049986-88062276 (-)
CBA/J MGP_CBAJ_G0030657
 protein coding gene Chr6:94852969-94865110 (-)
DBA/2J MGP_DBA2J_G0030813
 protein coding gene Chr6:84801707-84813866 (-)
FVB/NJ MGP_FVBNJ_G0030766
 protein coding gene Chr6:83982186-83994333 (-)
LP/J MGP_LPJ_G0030890
 protein coding gene Chr6:88952168-88964313 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030799
 protein coding gene Chr6:98994833-99006972 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031457
 protein coding gene Chr6:87815635-87827781 (-)
PWK/PhJ MGP_PWKPhJ_G0029797
 protein coding gene Chr6:83765181-83777276 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029625
 protein coding gene Chr6:86626587-86638707 (-)
WSB/EiJ MGP_WSBEiJ_G0030163
 protein coding gene Chr6:88276539-88288716 (-)



Homology
more
  • Human Ortholog
    PROKR1, prokineticin receptor 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PROKR1, prokineticin receptor 1
  • Synonyms
    GPR73, GPR73a, PK-R1, PKR1, ZAQ
  • Links
    NCBI Gene ID: 10887
    neXtProt AC: NX_Q8TCW9
    UniProt: Q8TCW9

  • Chr Location
    2p13.3; chr2:68643579-68658251 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 4 alleles in 4 genetic backgrounds
    2 images
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele exhibit abnormal nociceptions and hypoalgesia. Mice homozygous for another null allele exhibit decreased capillary density in the heart.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    869
  • Tissues
    56
  • cDNA Data
    8
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000049409 Ensembl Gene Model | MGI Sequence Detail 12153 C57BL/6J ±  kb
    transcript ENSMUST00000204682 Ensembl | MGI Sequence Detail 4230 Not Applicable  
    polypeptide ENSMUSP00000144999 Ensembl | MGI Sequence Detail 393 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 9
      Primer pair 3
      Other 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 13
      Gene Ontology 8
      Phenotypes 26
    • Earliest
      J:66307 Parker R, et al., Y-receptor-like genes GPR72 and GPR73: molecular cloning, genomic organisation and assignment to human chromosome 11q21.1 and 2p14 and mouse chromosome 9 and 6. Biochim Biophys Acta. 2000 Apr 25;1491(1-3):369-75
    • Latest
      J:351621 Mok J, et al., PROKR1-CREB-NR4A2 axis for oxidative muscle fiber specification and improvement of metabolic function. Proc Natl Acad Sci U S A. 2024 Jan 23;121(4):e2308960121
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory