Irx5 MGI Mouse Gene Detail - MGI:1859086

Symbol

Irx5
Name

Iroquois homeobox 5

Feature Type

protein coding gene
IDs

MGI:1859086
NCBI Gene: 54352
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr8:93084424-93088084 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 44.93 cM
Mapping Data

6 experiments

SNPs within 2kb

111 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1859086	protein coding gene	Chr8:93084253-93102914 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033934	protein coding gene	Chr8:93648973-93654229 (+)
A/J	MGP_AJ_G0033917	protein coding gene	Chr8:89960797-89964457 (+)
AKR/J	MGP_AKRJ_G0033843	protein coding gene	Chr8:92497538-92501220 (+)
BALB/cJ	MGP_BALBcJ_G0033909	protein coding gene	Chr8:90115814-90119765 (+)
C3H/HeJ	MGP_C3HHeJ_G0033619	protein coding gene	Chr8:93193929-93197589 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034430	protein coding gene	Chr8:97089255-97092915 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031371	protein coding gene	Chr8:83887602-83891254 (+)
CAST/EiJ	MGP_CASTEiJ_G0032951	protein coding gene	Chr8:92743149-92746812 (+)
CBA/J	MGP_CBAJ_G0033595	protein coding gene	Chr8:100328151-100334350 (+)
DBA/2J	MGP_DBA2J_G0033749	protein coding gene	Chr8:89508246-89511859 (+)
FVB/NJ	MGP_FVBNJ_G0033696	protein coding gene	Chr8:88438493-88443092 (+)
LP/J	MGP_LPJ_G0033841	protein coding gene	Chr8:93761819-93765285 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033738	protein coding gene	Chr8:102713972-102720111 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034448	protein coding gene	Chr8:92595806-92600365 (+)
PWK/PhJ	MGP_PWKPhJ_G0032653	protein coding gene	Chr8:88846876-88864729 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032490	protein coding gene	Chr8:91463194-91466860 (+)
WSB/EiJ	MGP_WSBEiJ_G0033063	protein coding gene	Chr8:93064577-93068242 (+)

Human Ortholog

IRX5, iroquois homeobox 5

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IRX5, iroquois homeobox 5
Synonyms

HMMS, IRX-2a, IRXB2
Links

HGNC:14361

NCBI Gene ID: 10265

neXtProt AC: NX_P78411

UniProt: P78411
Chr Location

16q12.2; chr16:54930865-54934485 (+) GRCh38

MGI Vertebrate Homology

Irx5 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: IRX5
Gene Tree

Irx5

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
12 phenotypes from multigenic genotypes
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

4
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit reduced body size, narrow eye opening, and impaired retinal cone bipolar cell development.

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All GO Annotations

22
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1130
Tissues

266
cDNA Data

35
Literature Summary

70

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase irx5

ZFIN irx5a, irx5b

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All Sequences

41
RefSeq

2
UniProt

3
CCDS

CCDS22522.1

Ensembl

ENSMUSG00000031737 (Evidence)
NCBI Gene

54352

			Length	Strain/Species	Flank
genomic	54352	NCBI Gene Model \| MGI Sequence Detail	3661	C57BL/6J	± kb
transcript	NM_018826	RefSeq \| MGI Sequence Detail	2421	ZRU/MplStud
polypeptide	Q9JKQ4	UniProt \| EBI \| MGI Sequence Detail	484	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000030461 iroquois-class homeodomain protein IRX-5

(term hierarchy)
InterPro Domains

IPR017970 Homeobox, conserved site

IPR001356 Homeobox domain

IPR008422 Homeobox KN domain

IPR009057 Homeobox-like domain superfamily

IPR003893 Iroquois-class homeodomain protein

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All nucleic 42

cDNA 36

Primer pair 3

Other 3

Microarray probesets 3

Summaries

All 112

Developmental Gene Expression 70

Gene Ontology 10

Phenotypes 20
Earliest

J:61328 Cohen DR, et al., Expression of two novel mouse iroquois homeobox genes during neurogenesis. Mech Dev. 2000 Mar 1;91(1-2):317-21
Latest

J:350460 Soussi G, et al., TBX3 is essential for establishment of the posterior boundary of anterior genes and upregulation of posterior genes together with HAND2 during the onset of limb bud development. Development. 2024 Jun 1;151(11)

TSS for Irx5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr78743	Chr8:93082591-93082637 (+)	-1,810 bp
Tssr78744	Chr8:93084368-93084379 (+)	-50 bp
Tssr78745	Chr8:93084415-93084429 (+)	-2 bp
Tssr78746	Chr8:93084462-93084519 (+)	67 bp
Tssr78747	Chr8:93084601-93084616 (+)	185 bp
Tssr78748	Chr8:93084631-93084639 (+)	211 bp
Tssr78749	Chr8:93084936-93084955 (+)	522 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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