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Tas2r105 Gene Detail
Summary
  • Symbol
    Tas2r105
  • Name
    taste receptor, type 2, member 105
  • Synonyms
    mGR05, mt2r5, T2R05, T2r5, T2R9, Tas2r5
  • Feature Type
    protein coding gene
  • IDs
    MGI:2681195
    NCBI Gene: 57252
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr6:131663524-131664426 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 63.53 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    131 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2681195
 protein coding gene Chr6:131663495-131664458 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031375
 protein coding gene Chr6:135645910-135646873 (-)
A/J MGP_AJ_G0031351
 protein coding gene Chr6:130372392-130373355 (-)
AKR/J MGP_AKRJ_G0031279
 protein coding gene Chr6:134178686-134179649 (-)
BALB/cJ MGP_BALBcJ_G0031358
 protein coding gene Chr6:130066436-130067399 (-)
C3H/HeJ MGP_C3HHeJ_G0031081
 protein coding gene Chr6:134260181-134261144 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031815
 protein coding gene Chr6:139299282-139300245 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028954
 protein coding gene Chr6:128651229-128652192 (-)
CAST/EiJ MGP_CASTEiJ_G0030452
 protein coding gene Chr6:134168046-134169009 (-)
CBA/J MGP_CBAJ_G0031040
 protein coding gene Chr6:144650878-144651841 (-)
DBA/2J MGP_DBA2J_G0031198
 protein coding gene Chr6:129298638-129299601 (-)
FVB/NJ MGP_FVBNJ_G0031147
 protein coding gene Chr6:128189053-128190016 (-)
LP/J MGP_LPJ_G0031279
 protein coding gene Chr6:135981704-135982667 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031186
 protein coding gene Chr6:148464406-148465369 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031850
 protein coding gene Chr6:134034164-134035127 (-)
PWK/PhJ MGP_PWKPhJ_G0030173
 protein coding gene Chr6:127635230-127636193 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030000
 protein coding gene Chr6:132263302-132264265 (-)
WSB/EiJ MGP_WSBEiJ_G0030539
 protein coding gene Chr6:134635072-134636035 (-)



Homology
more
  • Human Ortholog
    TAS2R10, taste 2 receptor member 10
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TAS2R10, taste 2 receptor member 10
  • Synonyms
    T2R10, TRB2
  • Links
    NCBI Gene ID: 50839
    neXtProt AC: NX_Q9NYW0
    UniProt: Q9NYW0

  • Chr Location
    12p13.2; chr12:10825219-10826358 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype reference
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation respond normally to a variety of bitter, sweet, umami, salty and sour stimuli but show a striking and selective impairement in their ability to taste cycloheximide (a bitter tastant). In addition, homozygotes are no longer behaviorally averse to cycloheximide.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    1
  • cDNA Data
    2
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 57252 NCBI Gene Model | MGI Sequence Detail 903 C57BL/6J ±  kb
    transcript NM_020501 RefSeq | MGI Sequence Detail 903 129X1/SvJ  
    polypeptide Q9JKT4 UniProt | EBI | MGI Sequence Detail 300 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 3
      cDNA 2
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 3
      Gene Ontology 8
      Phenotypes 1
    • Earliest
      J:61076 Adler E, et al., A novel family of mammalian taste receptors. Cell. 2000 Mar 17;100(6):693-702
    • Latest
      J:335201 Ohmoto M, et al., A Transcription Factor Etv1/Er81 Is Involved in the Differentiation of Sweet, Umami, and Sodium Taste Cells. eNeuro. 2023 Apr;10(4):ENEURO.0236-22.2023
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory