Lgals8 MGI Mouse Gene Detail - MGI:1928481 - lectin, galactose binding, soluble 8

Symbol

Lgals8
Name

lectin, galactose binding, soluble 8
Synonyms

1200015E08Rik, D13Ertd524e, Lgals-8

Feature Type

protein coding gene
IDs

MGI:1928481
NCBI Gene: 56048
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr13:12454296-12479825 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 4.64 cM
Mapping Data

5 experiments

SNPs within 2kb

827 from dbSNP Build 142
Strain Annotations

18
PCR

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1928481	protein coding gene	Chr13:12454283-12479857 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020231	protein coding gene	Chr13:9200898-9222399 (-)
A/J	MGP_AJ_G0020187	protein coding gene	Chr13:9025976-9047972 (-)
AKR/J	MGP_AKRJ_G0020162	protein coding gene	Chr13:9226396-9248040 (-)
BALB/cJ	MGP_BALBcJ_G0020170	protein coding gene	Chr13:9011464-9032675 (-)
C3H/HeJ	MGP_C3HHeJ_G0019974	protein coding gene	Chr13:9356947-9378399 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020617	protein coding gene	Chr13:9624377-9645144 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018224	protein coding gene	Chr13:8856475-8878206 (-)
CAST/EiJ	MGP_CASTEiJ_G0019512	protein coding gene	Chr13:9067210-9090219 (-)
CBA/J	MGP_CBAJ_G0019941	protein coding gene	Chr13:9879297-9900378 (-)
DBA/2J	MGP_DBA2J_G0020058	protein coding gene	Chr13:8846886-8867411 (-)
FVB/NJ	MGP_FVBNJ_G0020043	protein coding gene	Chr13:8664572-8685811 (-)
LP/J	MGP_LPJ_G0020132	protein coding gene	Chr13:9302590-9323102 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020079	protein coding gene	Chr13:10165645-10185183 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020645	protein coding gene	Chr13:9126423-9149203 (-)
PWK/PhJ	MGP_PWKPhJ_G0019275	protein coding gene	Chr13:8882854-8904681 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019082	protein coding gene	Chr13:9105166-9126369 (-)
WSB/EiJ	MGP_WSBEiJ_G0019572	protein coding gene	Chr13:9092127-9113012 (-)

Human Ortholog

LGALS8, galectin 8

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LGALS8, galectin 8
Synonyms

Gal-8, PCTA-1, PCTA1, Po66-CBP
Links

HGNC:6569

NCBI Gene ID: 3964

neXtProt AC: NX_O00214

UniProt: O00214
Chr Location

1q43; chr1:236518000-236552981 (+) GRCh38

MGI Vertebrate Homology

Lgals8 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: LGALS8
Gene Tree

Lgals8

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
2 images
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

3
Gene trapped

4
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

34 strains or lines available

Mice homozygous for a knock-out allele exhibit reduced VEGF-C-induced lymphangiogenesis, and ameliorated corneal pathology and lymphangiogenesis in a model of herpes simplex virus keratitis. Mice homozygous for a gene trapped allele exhibit hyperactivity.

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All GO Annotations

16
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

21

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA LGALS8

Xenbase lgals8

ZFIN lgals8b

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All Sequences

107
RefSeq

36
UniProt

5
CCDS

CCDS36592.1, CCDS70430.1, CCDS70431.1

Ensembl

ENSMUSG00000057554 (Evidence)
NCBI Gene

56048

			Length	Strain/Species	Flank
genomic	ENSMUSG00000057554	Ensembl Gene Model \| MGI Sequence Detail	25530	C57BL/6J	± kb
transcript	ENSMUST00000144283	Ensembl \| MGI Sequence Detail	1148	Not Applicable
polypeptide	ENSMUSP00000114200	Ensembl \| MGI Sequence Detail	325	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000009775 galectin-8

(term hierarchy)
InterPro Domains

IPR013320 Concanavalin A-like lectin/glucanase domain superfamily

IPR001079 Galectin, carbohydrate recognition domain

IPR044156 Galectin-like
GlyGen

Q9JL15 1 site, 1 N-linked glycan (1 site)

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All nucleic 24

cDNA 21

Primer pair 3

Microarray probesets 6

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MGI:1261882, MGI:1918987, MGI:2145217

Summaries

All 59

Gene Ontology 6

Phenotypes 23
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:342581 Morrison HM, et al., Deficiency in Galectin-3, -8, and -9 impairs immunity to chronic Mycobacterium tuberculosis infection but not acute infection with multiple intracellular pathogens. PLoS Pathog. 2023 Jun;19(6):e1011088

TSS for Lgals8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr121459	Chr13:12479832-12479840 (-)	-11 bp
Tssr121458	Chr13:12479806-12479830 (-)	7 bp
Tssr121457	Chr13:12476443-12476454 (-)	3,376 bp
Tssr121456	Chr13:12476419-12476430 (-)	3,400 bp
Tssr121455	Chr13:12476313-12476401 (-)	3,468 bp
Tssr121454	Chr13:12476291-12476298 (-)	3,530 bp
Tssr121453	Chr13:12475980-12475994 (-)	3,838 bp
Tssr121452	Chr13:12474149-12474163 (-)	5,669 bp
Tssr121451	Chr13:12474006-12474007 (-)	5,818 bp
Tssr121450	Chr13:12472331-12472343 (-)	7,488 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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