Prg3 MGI Mouse Gene Detail - MGI:1858200

Symbol

Prg3
Name

proteoglycan 3
Synonyms

major basic protein 2, MBP2

Feature Type

protein coding gene
IDs

MGI:1858200
NCBI Gene: 53856
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr2:84818559-84824230 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 49.45 cM
Mapping Data

2 experiments

SNPs within 2kb

237 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1858200	protein coding gene	Chr2:84818540-84826903 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025918	protein coding gene	Chr2:85694365-85700013 (+)
A/J	MGP_AJ_G0025892	protein coding gene	Chr2:82372977-82378587 (+)
AKR/J	MGP_AKRJ_G0025862	protein coding gene	Chr2:84503832-84511218 (+)
BALB/cJ	MGP_BALBcJ_G0025889	protein coding gene	Chr2:82503519-82509131 (+)
C3H/HeJ	MGP_C3HHeJ_G0025648	protein coding gene	Chr2:84734941-84740500 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026335	protein coding gene	Chr2:88348768-88355862 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023737	protein coding gene	Chr2:79200366-79206397 (+)
CAST/EiJ	MGP_CASTEiJ_G0025109	protein coding gene	Chr2:85282795-85291191 (+)
CBA/J	MGP_CBAJ_G0025629	protein coding gene	Chr2:91500039-91505648 (+)
DBA/2J	MGP_DBA2J_G0025760	protein coding gene	Chr2:81910045-81915845 (+)
FVB/NJ	MGP_FVBNJ_G0025723	protein coding gene	Chr2:81165012-81170632 (+)
LP/J	MGP_LPJ_G0025848	protein coding gene	Chr2:85485508-85491812 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025753	protein coding gene	Chr2:93820875-93826507 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026391	protein coding gene	Chr2:84751790-84757410 (+)
PWK/PhJ	MGP_PWKPhJ_G0024853	protein coding gene	Chr2:81754456-81760689 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024657	protein coding gene	Chr2:84873467-84879470 (+)
WSB/EiJ	MGP_WSBEiJ_G0025179	protein coding gene	Chr2:85409906-85417362 (+)

Human Ortholog

PRG3, proteoglycan 3, pro eosinophil major basic protein 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRG3, proteoglycan 3, pro eosinophil major basic protein 2
Synonyms

MBP2, MBPH
Links

HGNC:9363

NCBI Gene ID: 10394

neXtProt AC: NX_Q9Y2Y8

UniProt: Q9Y2Y8
Chr Location

11q12.1; chr11:57376769-57381150 (-) GRCh38

MGI Vertebrate Homology

Prg3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: PRG3
Gene Tree

Prg3

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

5
Genomic Mutations

3 involving Prg3
Incidental Mutations

APF
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

16
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

767
Tissues

29
cDNA Data

8
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

33
RefSeq

4
UniProt

1
CCDS

CCDS16199.1

Ensembl

ENSMUSG00000027072 (Evidence)
NCBI Gene

53856

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027072	Ensembl Gene Model \| MGI Sequence Detail	5672	C57BL/6J	± kb
transcript	ENSMUST00000028466	Ensembl \| MGI Sequence Detail	949	Not Applicable
polypeptide	ENSMUSP00000028466	Ensembl \| MGI Sequence Detail	222	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000013207 proteoglycan 3

(term hierarchy)
InterPro Domains

IPR018378 C-type lectin, conserved site

IPR016187 C-type lectin fold

IPR001304 C-type lectin-like

IPR016186 C-type lectin-like/link domain superfamily

IPR002352 Eosinophil major basic protein

IPR033816 Eosinophil major basic protein, C-type lectin-like domain

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All nucleic 10

Genomic 1

cDNA 8

Primer pair 1

Microarray probesets 2

Summaries

All 37

Developmental Gene Expression 3

Gene Ontology 4

Phenotypes 13
Earliest

J:61440 Macias MP, et al., Identification of a new murine eosinophil major basic protein (mMBP) gene: cloning and characterization of mMBP-2. J Leukoc Biol. 2000 Apr;67(4):567-76
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Prg3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr18717	Chr2:84818538-84818541 (+)	-19 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/22/2024 MGI 6.24