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Msrb1 Gene Detail
Summary
  • Symbol
    Msrb1
  • Name
    methionine sulfoxide reductase B1
  • Synonyms
    D17Wsu82e, SelR, Sepr, Sepx1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351642
    NCBI Gene: 27361
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
  • Candidate for QTL
    4 QTL
Location &
Maps
more
  • Sequence Map
    Chr17:24955616-24961752 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 12.53 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    244 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351642
 protein coding gene Chr17:24955567-24961752 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023321
 protein coding gene Chr17:23753372-23761254 (+)
A/J MGP_AJ_G0023281
 protein coding gene Chr17:23102477-23108634 (+)
AKR/J MGP_AKRJ_G0023248
 protein coding gene Chr17:23180442-23187559 (+)
BALB/cJ MGP_BALBcJ_G0023286
 protein coding gene Chr17:23300562-23306713 (+)
C3H/HeJ MGP_C3HHeJ_G0023046
 protein coding gene Chr17:23544028-23550162 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023729
 protein coding gene Chr17:24803532-24809668 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021204
 protein coding gene Chr17:20569052-20574954 (+)
CAST/EiJ MGP_CASTEiJ_G0022548
 protein coding gene Chr17:23398587-23405872 (+)
CBA/J MGP_CBAJ_G0023022
 protein coding gene Chr17:25657135-25666804 (+)
DBA/2J MGP_DBA2J_G0023151
 protein coding gene Chr17:22694827-22701131 (+)
FVB/NJ MGP_FVBNJ_G0023121
 protein coding gene Chr17:22413841-22419940 (+)
LP/J MGP_LPJ_G0023228
 protein coding gene Chr17:24061764-24070994 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023140
 protein coding gene Chr17:25349082-25356377 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023767
 protein coding gene Chr17:23463499-23470850 (+)
PWK/PhJ MGP_PWKPhJ_G0022297
 protein coding gene Chr17:21441303-21447729 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022112
 protein coding gene Chr17:21502730-21510141 (+)
WSB/EiJ MGP_WSBEiJ_G0022611
 protein coding gene Chr17:23537499-23547419 (+)



Homology
more
  • Human Ortholog
    MSRB1, methionine sulfoxide reductase B1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MSRB1, methionine sulfoxide reductase B1
  • Synonyms
    HSPC270, SELENOR, SELENOX, SELR, SELX, SepR, SEPX1
  • Links
    NCBI Gene ID: 51734
    neXtProt AC: NX_Q9NZV6
    UniProt: Q9NZV6

  • Chr Location
    16p13.3; chr16:1938229-1943199 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit oxidative stress.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    757
  • Tissues
    21
  • cDNA Data
    132
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000075705 Ensembl Gene Model | MGI Sequence Detail 6137 C57BL/6J ±  kb
transcript ENSMUST00000101800 Ensembl | MGI Sequence Detail 1211 Not Applicable  
polypeptide ENSMUSP00000099300 Ensembl | MGI Sequence Detail 116 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 134
    cDNA 133
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-33975, MGI:106283
References
more
  • Summaries
    All 46
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 13
  • Earliest
    J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
  • Latest
    J:348610 Yoo HJ, et al., MsrB1-regulated GAPDH oxidation plays programmatic roles in shaping metabolic and inflammatory signatures during macrophage activation. Cell Rep. 2022 Nov 8;41(6):111598
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory